Tag: "intracellular" at medical news

Autistic children's abnormal metabolic profile findings

...and colleagues measured plasma levels of the major intracellular antioxidant glutathione and its metabolic precursors in 95 autistic children and 75 children without autism. Glutathione levels (and also the ratio of reduced to oxidized glutathione or redox ratio) were significantly decreased in the autistic childr...

Pezcoller Foundation-AACR International Award for Cancer Research

... novel membrane lipid made by PI3K might act as an intracellular "messenger" by recruiting to the cell membrane the machinery (signaling proteins) needed to communicate a growth signal to the cell. Continuous activation of PI3K would allow the cell to continually grow and make copies of itself, resulting in a can...

News tips from the Journal of Neuroscience

...xample, mutant or overexpressed a synuclein causes intracellular inclusions (Lewy bodies) and cell degeneration of dopamine neurons. Such mechanisms are considered central to the pathogenesis of Parkinson's disease. This week, Cao et al. tested the protective ability of the chaperone protein torsinA in dopaminergi...

Scientists observe infectious prion proteins invade and move within brain cells

... on TSEs, I thought about them as being similar to intracellular bacterial pathogens--something that replicates within an animal or human host cell," says Dr. Baron. "I wanted to know how such a pathogen binds to the host cell, and how it enters, replicates and spreads to other cells." Dr. Baron says researchers h...

News tips from the Journal of Neuroscience

...administer anandamide. transporters and subsequent intracellular The authors also tested the stable synthetic analog methanandamide. Monkeys rapidly learned to press a lever to selfadminister intravenous anandamide or methanandamide with a pattern similar to cocaine....

Ingredient that makes curry yellow effective against melanoma cells

...ncer Society, the study also elucidates curcumin's intracellular mechanisms of action in this type of tumor. As we...o inhibit tumor growth and stimulate apoptosis, an intracellular mechanism for cells of all types to "kill" themselves. To evaluate the compound's efficacy in melano...

Depression linked to previously unknown dopamine regulator

... modulatory events in D2 dopamine receptormediated intracellular signaling may provide novel therapeutic targets for treating various associated disorders....

Notch signaling molecule important in type 2 immunity

...ount a healthy Th1 response to an infection by the intracellular parasite Leishmania major, showing that Notch signaling is specifically required for the Th2 arm of the immune system. These findings indicate that regulating Notch signaling may have a therapeutic role in treating diseases caused by abnormally incre...

Lipids play important role in nervous system development

...gulated, especially signaling proteins that enable intracellular chatter. "Now we have found this protein regulates lipids and lipids also travel," Dr. Xiong says. The mouse mutant is a clear example of what can happen when the lipids don't travel. The researchers also studied a similar mutant chick embryo that ha...

Compound from marine bacteria shows potential as multiple myeloma therapy

...b. Because NPI-0052 and bortezomib attack the same intracellular target in different ways, the Dana-Farber researchers contend that combining these two agents might be more effective than using either therapy alone and be better tolerated by patients as well. In preclinical studies, NPI-0052 blocks a wider range...

Yale study explains complex infection fighting mechanism

...isolation of certain TLRs within these specialized intracellular compartments is an important checkpoint in maintaining the balance between viral and self nucleic acid recognition. "This work has potential implications for our understanding of the molecular basis of lupus (SLE)," Barton said. "It is possible that...

Immune system response to viral DNA is unique

...le is known about whether cells can detect foreign intracellular DNA or how this system might function." Stetson a... the study, compared the innate immune response to intracellular DNA with other virus recognition pathways. "We found that this novel pathway seems to function diff...

Red wine components modulate tissue damage induced by bacteria in gum diseases

...cal generation by host immune cells by controlling intracellular proteins involved in their release. These anti-oxidant properties of red wine polyphenols could be useful in the prevention and treatment of inflammatory periodontal diseases as well as other disorders involving free radicals....

Potential heart benefit found in stem cells

...tissue, and connexin 43, a protein that assists in intracellular interactions The in vitro data suggests that stem cells from this source have significant CM potential and are potentially valuable not only because they can be easily collected from young volunteers, but also because of their collection-efficacy. A...

New family of biodegradable polymers shows promise for intracellular drug delivery

...degradable polymers has shown potential for use in intracellular delivery and sustained release of therapeutic drug...c environments of tumors, inflammatory tissues and intracellular vesicles that hold foreign matter. These polymers have several advantages over existing biodegradab...

Agent protects Parkinson's neurons from rotenone toxicity

...eagues earlier demonstrated that microtubules, the intracellular highways for transporting dopamine and many vital cellular components, are critical for the survival of dopamine neurons, which are responsible for controlling body movement. They showed that rotenone kills dopamine neurons by destroying microtubule...

JCI table of contents, May 11, 2006

...treatment of bipolar disorder Calcium is a common intracellular signaling molecule with a wide range of functions ...sregulation of calcium signaling via the principal intracellular calcium release channel, InsP3R1, has been linked to many normal cellular processes as well as neuro...

News tips from The Journal of Neuroscience

...ere initially detected using stepwise increases in intracellular calcium, but this week Sakaba examined vesicular r...tian Tackenberg, and Roland Brandt Accumulation of intracellular hyperphosphorylated tau-containing fibrils is a hallmark of Alzheimer's disease as well as several o...

News Tips from The Journal of Neuroscience

...perate by binding to patched receptors and trigger intracellular signaling cascades that control such things as tissue patterning during development. Sharghi-Namini et al. examined mice deficient for desert hedgehog (dhh) that is selectively expressed and secreted from myelinating Schwann cells. Previous studies...

Mechanism for neurodenegerative diseases linked to transport proteins

...tive diseases to mutations in proteins involved in intracellular transport. This led researchers to wonder if the deranged polyQ proteins inhibit fast axonal transport in several diseases, including SBMA, in which a mutation in the receptor for testosterone leads to the loss of motor neurons. In the new study, Bra...

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(Date:7/30/2014)... A group of researchers from the University of Helsinki ... experimentally to reproduce in mice morphological changes which have ... gradual modifications in the embryonic development of mice teeth, ... morphologically are very similar to those observed in the ... millions of years ago. , To modify the ...
(Date:7/30/2014)... is pleased to announce its new relationship with the ... and CINP will partner to publish International Journal ... open-access journal. , Alan Frazer, Editor-in-Chief of IJNP ... expertise of OUP will further facilitate the goal for ... very leading journals within neuropsychopharmacology. The conversion of the ...
(Date:7/30/2014)... $1 million from the Cornelia Cogswell Rossi Foundation to ... , The newly established Connie Cogswell Rossi ... a greater breadth and depth of knowledge of neurobehavioral ... of research to improve human health. , The new ... Laboratory and its external partners, supporting research to enhance ...
Breaking Biology News(10 mins):Scientists reproduce evolutionary changes by manipulating embryonic development of mice 2OUP to partner with the International College of Neuropsychopharmacology 2Rossi Foundation pledges $1M for JAX neurobehavioral research center 2
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