Tag: "intracellular" at medical news
Autistic children's abnormal metabolic profile findings
...and colleagues measured plasma levels of the major intracellular
antioxidant glutathione and its metabolic precursors in 95 autistic children and 75 children without autism. Glutathione levels (and also the ratio of reduced to oxidized glutathione or redox ratio) were significantly decreased in the autistic childr...
Pezcoller Foundation-AACR International Award for Cancer Research
... novel membrane lipid made by PI3K might act as an intracellular
"messenger" by recruiting to the cell membrane the machinery (signaling proteins) needed to communicate a growth signal to the cell. Continuous activation of PI3K would allow the cell to continually grow and make copies of itself, resulting in a can...
News tips from the Journal of Neuroscience
...xample, mutant or overexpressed a synuclein causes intracellular
inclusions (Lewy bodies) and cell degeneration of dopamine neurons. Such mechanisms are considered central to the pathogenesis of Parkinson's disease. This week, Cao et al. tested the protective ability of the chaperone protein torsinA in dopaminergi...
Scientists observe infectious prion proteins invade and move within brain cells
... on TSEs, I thought about them as being similar to intracellular
bacterial pathogens--something that replicates within an animal or human host cell," says Dr. Baron. "I wanted to know how such a pathogen binds to the host cell, and how it enters, replicates and spreads to other cells." Dr. Baron says researchers h...
News tips from the Journal of Neuroscience
...administer anandamide. transporters and subsequent intracellular
The authors also tested the stable synthetic analog methanandamide. Monkeys rapidly learned to press a lever to selfadminister intravenous anandamide or methanandamide with a pattern similar to cocaine....
Ingredient that makes curry yellow effective against melanoma cells
...ncer Society, the study also elucidates curcumin's intracellular
mechanisms of action in this type of tumor. As we...o inhibit tumor growth and stimulate apoptosis, an intracellular
mechanism for cells of all types to "kill" themselves. To evaluate the compound's efficacy in melano...
Depression linked to previously unknown dopamine regulator
... modulatory events in D2 dopamine receptormediated intracellular
signaling may provide novel therapeutic targets for treating various associated disorders....
Notch signaling molecule important in type 2 immunity
...ount a healthy Th1 response to an infection by the intracellular
parasite Leishmania major, showing that Notch signaling is specifically required for the Th2 arm of the immune system. These findings indicate that regulating Notch signaling may have a therapeutic role in treating diseases caused by abnormally incre...
Lipids play important role in nervous system development
...gulated, especially signaling proteins that enable intracellular
chatter. "Now we have found this protein regulates lipids and lipids also travel," Dr. Xiong says. The mouse mutant is a clear example of what can happen when the lipids don't travel. The researchers also studied a similar mutant chick embryo that ha...
Compound from marine bacteria shows potential as multiple myeloma therapy
...b. Because NPI-0052 and bortezomib attack the same intracellular
target in different ways, the Dana-Farber researchers contend that combining these two agents might be more effective than using either therapy alone and be better tolerated by patients as well. In preclinical studies, NPI-0052 blocks a wider range...
Yale study explains complex infection fighting mechanism
...isolation of certain TLRs within these specialized intracellular
compartments is an important checkpoint in maintaining the balance between viral and self nucleic acid recognition. "This work has potential implications for our understanding of the molecular basis of lupus (SLE)," Barton said. "It is possible that...
Immune system response to viral DNA is unique
...le is known about whether cells can detect foreign intracellular
DNA or how this system might function." Stetson a... the study, compared the innate immune response to intracellular
DNA with other virus recognition pathways. "We found that this novel pathway seems to function diff...
Red wine components modulate tissue damage induced by bacteria in gum diseases
...cal generation by host immune cells by controlling intracellular
proteins involved in their release. These anti-oxidant properties of red wine polyphenols could be useful in the prevention and treatment of inflammatory periodontal diseases as well as other disorders involving free radicals....
Potential heart benefit found in stem cells
...tissue, and connexin 43, a protein that assists in intracellular
interactions The in vitro data suggests that stem cells from this source have significant CM potential and are potentially valuable not only because they can be easily collected from young volunteers, but also because of their collection-efficacy. A...
New family of biodegradable polymers shows promise for intracellular drug delivery
...degradable polymers has shown potential for use in intracellular
delivery and sustained release of therapeutic drug...c environments of tumors, inflammatory tissues and intracellular
vesicles that hold foreign matter. These polymers have several advantages over existing biodegradab...
Agent protects Parkinson's neurons from rotenone toxicity
...eagues earlier demonstrated that microtubules, the intracellular
highways for transporting dopamine and many vital cellular components, are critical for the survival of dopamine neurons, which are responsible for controlling body movement. They showed that rotenone kills dopamine neurons by destroying microtubule...
JCI table of contents, May 11, 2006
...treatment of bipolar disorder Calcium is a common intracellular
signaling molecule with a wide range of functions ...sregulation of calcium signaling via the principal intracellular
calcium release channel, InsP3R1, has been linked to many normal cellular processes as well as neuro...
News tips from The Journal of Neuroscience
...ere initially detected using stepwise increases in intracellular
calcium, but this week Sakaba examined vesicular r...tian Tackenberg, and Roland Brandt Accumulation of intracellular
hyperphosphorylated tau-containing fibrils is a hallmark of Alzheimer's disease as well as several o...
News Tips from The Journal of Neuroscience
...perate by binding to patched receptors and trigger intracellular
signaling cascades that control such things as tissue patterning during development. Sharghi-Namini et al. examined mice deficient for desert hedgehog (dhh) that is selectively expressed and secreted from myelinating Schwann cells. Previous studies...
Mechanism for neurodenegerative diseases linked to transport proteins
...tive diseases to mutations in proteins involved in intracellular
transport. This led researchers to wonder if the deranged polyQ proteins inhibit fast axonal transport in several diseases, including SBMA, in which a mutation in the receptor for testosterone leads to the loss of motor neurons. In the new study, Bra...