New mechanism identified for resistance to targeted lung cancer drugs
...ps within the EGFR gene. A new group of so-called irreversible EGFR inhibitors that permanently bind to the protein are currently being tested in clinical trials. But what leads to other cases of resistance has been unknown, and the current study was designed to discover additional mechanisms. To do so, the ...ACE inhibitors help preserve kidney function in IgA nephropathy
... (ACE) inhibitors can reduce the long-term risk of irreversible kidney damage, suggests a study in the June Journal of the American Society of Nephrology. "These results in young patients are of particular interest because they could offer a way of limiting the future need for renal replacement therapy in patie...Researchers begin randomized double-blind trial of airway bypass treatment for emphysema
...nths. Emphysema is a chronic, progressive, and irreversible lung disease characterized by the destruction of lung tissue. The loss of the lungs' natural elasticity and the collapse of airways in the lung combine to make exhalation ineffective, leaving the emphysema sufferer with hyperinflation because they ca...Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
...he same: escalating levels of blood nitrogen cause irreversible brain damage, coma and death. If a diagnosis is made quickly enough, dialysis can help to cleanse the blood of excess nitrogen during an episode and prevent brain damage. Traditional treatments included maintaining a very-low protein diet that is...Human stem cell treatment restores motor function in paralyzed rats
...urons called spinal inhibitory neurons, leading to irreversible spasticity and rigidity, or loss of muscle control, in the lower limbs, even though the spinal cord is intact. The important difference between spinal cord ischemia and spinal cord trauma, such as might occur in a diving or car accident, is that in...