Tag: "islet" at medical news
Propensity for obesity, diabetes, may occur in utero
...n body weight, plasma glucose level or a change in islet
structure. They also found changes in the hypothalamus, the brain's center of appetite regulation, that result in appetite stimulation. While these studies were done with rats, Mulchand Patel, Ph.D, UB distinguished professor of biochemistry and f...
Rare surgery performed to remove pancreas, prevent diabetes
...ancreas and the hours-long wait for the pancreatic islet
cells to be processed in a specialized UAB laborat...ies necessary to isolate and purify the pancreatic islet
cells either from a cadaver donor for transplantation or, as in this case, for infusion back into th...
Insulin-producing cells from brain cursors
... one way of producing insulin-secreting pancreatic islet
cells for future possible treatment of type I diab...ries of signals that are known to drive pancreatic islet
development. They were able to produce clusters of insulin-producing cells that responded to glucose...
New therapy may give options to those with neuroendocrine tumors
...clinical trial for carcinoid tumors and pancreatic islet
cell tumors. About 80 percent of patients saw thei...opped growing), and about 10 percent of those with islet
cell tumors had tumors that actually partially shrank in response to the drug. Carcinoid and pancrea...
Potential new treatment for insulin-dependent diabetes
...he insulin-producing cells in the pancreas (called islet
cells) by auto-reactive T cells. The loss of insu...to control blood sugar levels. Transplantation of islet
cells is an effective way to restore insulin production, but this therapy requires life-long immunos...
A new blueprint to aid physicians in predicting risk for type 1 diabetes
...for type 1 diabetes by identifying what are called islet
cell antibodies. These are produced when the body'...mmune system fails to recognize insulin-generating islet
cells produced by the pancreas as self, and attacks them as if they were foreign cells. The islet
How do islet cells die during early stages of diabetes?
...rts attacking and destroying the insulin-producing islet
cells in the pancreas. Once the majority of islet
cells are destroyed, patients can no longer produce insulin to regulate their blood sugar and depend...
Early, aggressive treatment of type 1 diabetes lowers risk of cardiovascular disease
... is associated with a lack of insulin. Pancreatic islet
cells quit producing insulin in the quantities needed to maintain a normal blood glucose level, and patients must regiment their diets and take insulin daily to metabolize blood glucose. Type 1 diabetes accounts for between 5 percent and 10 percent o...
U of M reaches milestone in diabetes research using pig islets
...ly reversed diabetes in monkeys using transplanted islet
cells from pigs. Survival of pig islet
transplants was made possible with a novel immunosuppressive protocol. Graft survival did not requir...
Diabetes researchers pioneer islet cell xenotransplantation in primate studies
...ly transplanted insulin-producing neonatal porcine islet
cells into monkeys, a procedure the researchers sa...olution to the critical supply problem in clinical islet
cell transplantation. "Our work at the U of A and Emory, along with recent work at the University of...
Porcine islets offer promise for human diabetic patients
...promising near-term solution to the critically low islet
cell supply for humans suffering from type 1 diabe...d and engrafted insulin-producing neonatal porcine islet
cells harvested by the University of Alberta researchers into diabetic rhesus macaque monkeys, resto...
Procedure cures some diabetic mice, but not in the way previously reported
...esearchers gave the mice the CFA injection and the islet
transplants but did not give spleen cell injections. For periods of more than 100 days, this temporarily cured diabetes in 69 percent of the mice that received it (20 of 29). The procedure that included the spleen injection had a temporary cure rate ...
Reduced insulin in the brain triggers Alzheimer's degeneration
...ent caused neurodegeneration, while the pancreatic islet
cells remained intact. That is because insulin depletion produced by STZ was confined to the brain, just like what occurs in most cases of Alzheimer's. "This study provides definitive evidence that impairments in insulin/IGF signaling and deficiencie...
Shock wave therapy for kidney stones linked to increased risk of diabetes, hypertension
...ly known risk of lithotripsy, which may affect the islet
cells in the pancreas that make insulin. They believe the increased risk for hypertension may relate to scarring, which the treatment may cause to the kidneys and could alter the secretion of hormones centered in the kidneys like renin, which influen...
JCI table of contents, April 20, 2006
...ory molecules to the pancreatic islets by inducing islet
antigenspecific Tregs. However, this intervention ...ttacked by the autoreactive T cells were no longer islet
beta cells, but acinar cells in the mouse pancreas. This change in specificity was associated with p...
Dynamic duo: Combination therapy reverses type 1 diabetes
...ory molecules to the pancreatic islets by inducing islet
antigenspecific Tregs. However, this intervention only appears effective early in the pre-diabetic stage. In their JCI study, von Herrath and colleagues show that combination treatment with a low-dose, orally-delivered CD3epsilon-specific antibody as...
A non-invasive method for measuring beta cell mass during diabetes
Diabetes results from a reduction in the number of islet
beta cells in the pancreas, which leads to insuffi...oamine transporters (VMAT2) are expressed in human islet
beta cells within the pancreas, as well as in tissues of the central nervous system. As the radiolig...
MRI can track survival of pancreatic islets after transplantation
...his loss and how it proceeds over time. Monitoring islet
survival by noninvasive imaging could give us the ability to detect and measure rates of islet
loss under a variety of conditions, which could help develop procedures leading to better therapeuti...
Hope for significant new diabetes treatment in Stanford discovery
...whose work in diabetes includes the development of islet
cells, identifying new drug targets and potential stem cell treatments, said the calcineurin findings have wide-ranging implications. "The finding that the calcineurin pathway regulates other pathways in the beta cell makes it highly relevant to many...
Landmark study of islet transplantation reveals potential benefits in uncontrolled type 1 diabetes
...of the world's first multicenter clinical trial of islet
transplantation have confirmed the technique's pot...nvestigators report that the Edmonton Protocol for islet
transplantation can safely and successfully promote long-term stabilization of blood sugar levels in...