Jefferson scientists find that drug-eluting stents are disappointing in bypass grafts -- sometimes
... The researchers looked at the success of drug-eluting stents in bypassed vein grafts and found that long-term success was dependent on the healthiness of t...Jefferson researchers uncover genetic signature that predicts colon cancer
(PHILADELPHIA) Researchers at Jefferson Medical College in Philadelphia have uncovered a genetic "signature" that accurately identifies colon cancer--a key, they hope, to better understand how the cancer develops.... Colon cancer may begin when processes that regulate adult stem cells in the colon go awry. A handful of stem cells lie in the bottom of tiny tube-like "crypts" in the epithelium (or...Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
... <p...Jefferson pharmacologist says biomarker discovery bodes well for better cancer diagnostics
... The researchers have identified "a new level of biological regulation" and potentially an improved way to profile tumors, says Scott Waldman, M.D., Ph.D., professor and chair of pharmacology and experimental therapeutics at Jefferson Medical College...Jefferson immunology researchers show blood-brain barrier damage could affect MS severity
... Scientists led by D. Craig Hooper, Ph.D., ass...Jefferson scientists find that plavix appears to be safe during and after heart bypass
... ... ...Treatment of in-hospital cardiac patients is focus of Jefferson University presentations
... ...(Embargoed for release 9 am, Tuesday, March 27; Abstract #1028-68) ... Although anemia is a common problem in heart failure patients, the medications the patients take to control their heart failure are not the cause of the anemia, according to rese...Empathy skills must be given a high priority in medical education, says Jefferson author
... "If we want to train physicians with more empathy, then education must shift from emphasizing only the biomedical to also providing a biopsychosocial framework, as well and a more complete picture of patients as persons," says Mohammadreza Hojat, Ph.D., research professor of psychiatry and human behavior at Jef...Natural, soy-based substance might help fight MS, Jefferson neuroscientists find
... Using an animal model of MS, neurologists at Jefferson Medical College found that giving doses of a substance called Bowmann-Birk Inhibitor Concentrate (BBIC) dramatically improved the animals ability to move and walk. The scientists, led by A. M. Rostami, M.D., Ph.D., professor and chair of the Department of Neurology at Jefferson Medical College of Thomas Jefferson University and the Jeff...Blood pressure drugs could help halt pancreatic cancer spread, Jefferson researchers find
... According to Hwyda Arafat, M.D., Ph.D., assistant professor of surgery...Obesity tied to higher risk of complications in spinal surgery, Jefferson neurosurgeon finds
(PHILADELPHIA) While obesity is famously tied to increasing risks for heart disease and diabetes, now comes another reason to lose weight: being obese may contribute to a greater likelihood of complications in delicate spine surgery.... John Ratliff, M.D., assistant professor of neurological surgery and orthopedic surgery at Jefferson Medical College of Thomas Jefferson University in Philadelphi...Jefferson Orthopaedic surgeons leading international study of timing of spinal surgery
... Dr. Vaccaro, professor of orthopaedic surgery and neurological surgery at Jefferson Medical College of Thomas Jefferson University in Philadelphia and the Rothman Institute at Thomas Jefferson University Hospital and his colleagues are trying to answer a very difficult and controversial question: Should surgeons operate immediately, within hours of the severe spin...Jefferson scientists find boosting protein levels staves off heart failure
... Cardiology researchers at the Center for Translational Medicine at Jefferson Medical College of Thomas Jefferson University in Philadelphia found that increasing levels of the protein S100A1 above normal helped protect animal hearts from further damage after simulated heart attacks. In some cases, the animals' heart function hardly changed at all. At the same time, other animals with heart...New drug target might sidestep gleevec resistance, Jefferson scientists show
... A drug that could turn on the gene that makes the...Jefferson researchers find potential biomarket for heart failure
... "These findings add to the growing evidence that GRK2 is a biomarker for heart failure," says Walter Koch, Ph.D., director of the Center for Translational Medicine in the Department of Medicine at Jefferson Medical College of Thomas Jefferson University in Philadelphia. Dr. Koch previously demonstrated that GRK2...Jefferson radiation oncologists among first to use cone beam CT to improve treatment accuracy
... Thomas Jefferson University Hospital in Philadelphia and the Kimmel Cancer Center at ...Jefferson are among the first centers in the nation to study the effect of inc...Jefferson scientists show 'miracle' cancer drug Gleevec can be toxic to the heart
(Philadelphia) Gleevec, the wildly successful poster-child of a new generation of cancer drugs aimed at specific targets in the cancer cell, can be dangerous to the heart. Not only that, but other similarly based drugs called tyrosine kinase inhibitors could lead to heart problems as well, say researchers at the Center for Translational Medicine at Jefferson Medical College in Philadelphia. .....Enzyme inhibitor may provide strategy to treat some GI disorders, Jefferson researchers find
... Researchers led by Satish Rattan, DVM, professor of medicine in the Division of Gastroenterology and Hepatology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, have shown that the enzyme Rho kinase (ROK) plays an important role in maintaining the tone of the internal anal sphincter (IAS), which is cr...Jefferson team designs program that helps elderly perform daily living tasks and live longer
... Laura Gitlin, Ph.D., director of the Center for Applied Research on Aging and Health at Thomas Jefferson University in Philadelphia and her team reported previously that a brief six-visit program consisting of physical therapy, occupational therapy, home modification and some instruction in problem-solving helped elderly indi...Pancreatic cancer surgery can help those over 80, Jefferson surgeons find
PHILADELPHIA-Age doesn't necessarily have to be the deciding factor for cancer surgery, Jefferson Medical College surgeons have found. ...... Pancreatic cancer surgeon Charles J. Yeo, M.D., Samuel D. Gross Professor and chair of surgery at Jefferson Medical College of Thomas Jefferson University and Thomas Jefferson University Hospital in Philadelphia and Jefferson's Kimmel Cancer Center, and his...Timing of radiation treatments for colon cancer may need adjusting, Jefferson researchers say
(PHILADELPHIA) Scientists have unexpectedly discovered that mice with the gene defect that causes colon cancer in humans can differ from normal mice in how they respond to radiation treatments. The large intestine carrying the gene defect in mice that received staggered doses of radiation was three to four times more resistant to the radiation than in control mice....... The researchers, led by B...Jefferson researchers discover that nanoparticle shows promise in reducing radiation side effects
(PHILADELPHIA) Using transparent zebrafish embryos, researchers at Jefferson Medical College in Philadelphia have shown that a microscopic nanoparticle can help fend off damage to normal tissue from radiation. The nanoparticle, a soccer ball-shaped, hollow, carbon-based structure known as a fullerene, acts like an "oxygen sink," binding to dangerous oxygen radicals produced by radiation.... The s...Jefferson scientists reveal new mechanism that causes spread of colorectal cancer
(PHILADELPHIA) Researchers have known for years that the enzyme MMP-9 plays a key role in the spread of colorectal cancer. Now, scientists at Jefferson Medical College in Philadelphia have found out how the enzyme helps initiate the process, known as metastasis. Their discovery of a new molecular mechanism by which MMP-9 promotes cancer spread may provide a new target at which to aim anti-metasta...Jefferson neurosurgeons using innovative stent to open clogged brain arteries, prevent strokes
Neurosurgeons at Thomas Jefferson University Hospital in Philadelphia are the first in the region and among the first in the nation to successfully use a new stent specifically designed to open potentially life-threatening clogged arteries in the brain, preventing a stroke....... The device, called the Wingspan Stent System, is used for individuals with intracranial atherosclerotic disease, which...Jefferson scientists test new device for fixing holes in hearts of young stroke patients
Philadelphia, Pa.--As many as one in four adults is walking around with a "hole" between the upper chambers of the heart. Most of them will never know it.... The person who learns about the "hole" in his or her heart does so when he or she suffers symptoms of a mini-stroke (TIA) or a more-debilitating stroke. And it is usually only then that the person learns the term Patent Foramen Ovale (PFO),...Jefferson scientists find topical lubrication helps outcomes of coronary stent procedures
Philadelphia, Pa.--An emulsion of olive oil, egg yolk and glycerine might be just the recipe to keep heart patients away from the operating room and cardiac bypass surgery.... That's the finding of a study led by Michael Savage, M.D., director, Cardiac Catheterization Laboratory at Thomas Jefferson University Hospital, Philadelphia. The mixture is not swallowed, he explains. Rather, it is used in...Jefferson Pancreatic Cancer Conference Feb. 24 highlights treatments, trials, vaccine research
(PHILADELPHIA) Pancreatic cancer is no longer the immediate death sentence that most people think it is.... "The public hears 'pancreatic cancer' and thinks there's little hope and there isn't much to do," says pancreatic cancer surgeon Charles Yeo, M.D., professor and chair of surgery at Jefferson Medical College of Thomas Jefferson University in Philadelphia. "The good news is, with new imaging...New, expensive, widely-used drugs continue to cause liver problems, says Jefferson liver specialist
Adverse drug reactions in the liver are the most common reason for drugs to be taken off the market, and the federal Food and Drug Administration now wants better ways to detect these problem drugs before they reach the market and injure users....... In an article published this week in the influential New England Journal of Medicine, lead author Victor J. Navarro, M.D., clinical associate profes...New infectious agents pose new risks for people with bleeding disorders, Jefferson hematologist says
An international team of scientists, including a hematologist from Thomas Jefferson University in Philadelphia, has concluded that people with bleeding disorders such as hemophilia remain at risk from emerging infectious agents in plasma and blood transfusions. For this reason, recombinant therapies, that is, those produced in the laboratory, must always be an option. ...Writing January 21, 2006...Jefferson researchers building a better rabies vaccine
In an unexpected discovery, scientists at Jefferson Medical College have found that a tiny change in a rabies virus protein can turn a "safe" virus extremely deadly. The finding has enabled the researchers to refine a vaccine they previously created against rabies in wildlife, making it safer and more effective....... "We have identified a molecular mechanism involved in making the rabies virus p...Jefferson scientists discover mechanism tying obesity to Alzheimer's disease
If heart disease and diabetes aren't bad enough, now comes another reason to watch your weight. According to a study just released, packing on too many pounds can increase the risk of developing Alzheimer's disease. ...A team led by researchers at the Farber Institute for Neurosciences at Thomas Jefferson University in Philadelphia and Edith Cowan University in Joondalup, Western Australia has sh...Over-the-counter arthritis drug might also help against MS, Jefferson neuroscientists find
Glucosamine, the over-the counter natural product that has been touted to help with joint and cartilage problems associated with arthritis, may also provide some relief to individuals with multiple sclerosis (MS), a degenerative, nervous system disease with no known cure....... Using a mouse model of MS, neurologists at Jefferson Medical College found that doses of glucosamine similar to those ta...Jefferson and Delaware researchers combine tiny nanotubes and antibodies to detect cancer
By coating the surfaces of tiny carbon nanotubes with monoclonal antibodies, biochemists and engineers at Jefferson Medical College and the University of Delaware have teamed up to detect cancer cells in a tiny drop of water. The work is aimed at developing nanotube-based biosensors that can spot cancer cells circulating in the blood from a treated tumor that has returned or from a new cancer. .....Jefferson researchers find drug may give some cardiac protection 24 hours after heart attack
A drug has been shown to provide some protection to the heart from injury even if given as much as 24 hours after a heart attack, Jefferson Medical College researchers report. ...Walter Koch, Ph.D., director of the Center for Translational Medicine in the Department of Medicine at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and his co-workers knew that the drug Darbe...Jefferson scientists show protein in heart and adrenal gland plays critical role in heart failure
A protein that plays an important regulatory role in heart failure in the heart also exerts powerful effects on the adrenal gland, Jefferson Medical College researchers have found. The protein, GRK2, is a potential drug target for heart failure.... ...Walter Koch, Ph.D., director of the Center for Translational Medicine in the Department of Medicine at Jefferson Medical College of Thomas Jefferso...Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
Using transparent zebrafish embryos, researchers at Jefferson Medical College have shown that a microscopic nanoparticle can help fend off damage to normal tissue from radiation. The nanoparticle, a soccer ball-shaped, hollow, carbon-based structure known as a fullerene, acts like an "oxygen sink," binding to dangerous oxygen radicals produced by radiation. ... ... The scientists, led by Adam Dic...Jefferson researchers find lack of protein in obese people is risk factor for kidney, heart disease
Jefferson researchers have found that mice with low levels of the protein hormone adiponectin may also have high levels of a protein called albumin which, in humans, may be a sign of kidney disease. This study provides further support for the theory that kidney disease may be a more important risk factor for heart disease than is cholesterol. ... Nephrologists at Thomas Jefferson University, Phil...Jefferson scientists uncover more evidence for protein's role in artery blockage
Researchers at Jefferson Medical College have begun to clarify the role of a protein and potential drug target in the process by which arteries re-clog after treatment. ...The process called restenosis is due to an unregulated growth and movement of cells in the vessel. ...Scientists have known that G-protein coupled receptors are involved in the growth and migration of cells, and alteration...New model shows gender differences in high blood pressure, Jefferson scientists find
Researchers at Jefferson Medical College have implicated a protein called GRK5 as having an important role behind essential hypertension, which affects more than 65 million Americans. ...When Andrea Eckhart, Ph.D., associate professor of medicine at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and her co-workers turned up the volume on GRK5, overexpressing a mouse gen...Jefferson scientists design method to fight artificial implant infections with antibiotics
Infections associated with inserting a medical device can be devastating, painful, and cause prolonged disability, costing tens of thousands of dollars. ... Now, researchers at Jefferson Medical College have found a way to create a permanent chemical bond between antibiotics and titanium, a material used in orthopedic implants. The proof-of-principle study showed that an antibiotic can be connect...