Excess oxygen worsens lung inflammation in mice
...ky and his colleagues have shown that inflammation leads to a drop in oxygen levels in the inflamed tissues. This, in turn, triggers the release of adenosine from surrounding cells. When adenosine binds to cell receptors in the inflamed region, it serves as a tissue-protecting stop signal, slowing the floo...Study is first to implicate dietary fat in 'fatty liver'
...The clear implication is that too much dietary fat leads the liver to fail in its mission as the body's cen...ize Me,' fat becomes deposited in the liver. This leads to a kind of liver toxicity that would be good to avoid," said Parks....Stroke drug still meets resistance from doctors wary of its risks
...ing, when it should be the medical literature that leads the way," says Brown. No matter what, Brown and her colleagues say, it will be important to find alternatives or additions to tPA. She cites current and planned clinical trials of drugs that may reduce the risk of hemorrhage, such as beta blockers o...UCI epilepsy researcher receives nation's top neuroscience prize
... Soltesz lab focuses on how traumatic brain injury leads to seizures and epilepsy. More than a million people suffer traumatic brain injury in the United States every year, and head injury is the leading cause of death and disability among young adults. It is estimated that the overall economic cost of tra...Study finds maternal exposure to parasitic infection may increase risk of schizophrenia in offspring
...his risk. "Evidence from this and previous studies leads us to consider that the increased risk for schizophrenia may not stem from exposure to a specific infectious disease, but from a mechanism secondary to infection, such as inflammation," said Ezra Susser, MD, DrPH, Anna Cheskis Gelman and Murray Charl...Babies' cries linked to their health
...nt, so the cry signal can be an early warning that leads to further neurological testing," says LaGasse. Overall, studies have repeatedly shown that infants at medical risk (like premature babies), and infants who have been exposed to lead or drugs, cry at a higher and more variable frequency than normal,...Researchers prevent post-traumatic brain damage
...dical Center have shown how traumatic brain injury leads to loss of brain function--and found that an experimental drug can stop the damage and promote recovery. In a study published in the Proceedings of the National Academy of Sciences (PNAS), the researchers say their findings may hold promise for the t...Biologic therapies for bowel disease show promise in clinical trials
...urrently affects more than a million Americans and leads to many millions of dollars in lost productivity and missed days of work every year. IBD is an umbrella term referring to several chronic diseases that cause inflammation of the intestines, including ulcerative colitis and Crohn's disease. Symptoms...Timing of introduction of gluten into infant's diet associated with appearance of celiac disease
...possibility that earlier exposure to gluten simply leads to earlier appearance of CDA and that all exposed ... clarify whether earlier exposure to gluten simply leads to earlier appearance of tTG [tissue transglutaminase, an autoantigen] or whether all exposed at-ris...Testicular cancer gene in mice may offer clues to origins of cancer in men
...n a laboratory fish model of reproductive diseases leads to the inability to procreate. "And in humans, testicular cancer and infertility have been frequently associated with one another," Matin notes. Still, the researchers say this study is most relevant to human testicular cancer. According to the Natio...Umbilical cord-blood transplants save lives of babies with rare genetic disorder
...of the enzyme galactocerebrosidase, or GALC, which leads to a loss of myelin, a fatty covering that wraps around and protects nerve fibers in the brain. Without myelin, nerves in the brain and other parts of the body cannot function properly. Previous studies have shown that individuals with late onset Kra...Study finds drug works against scleroderma lung disease
...States. Scleroderma is a progressive disease that leads to the hardening and tightening of the skin and co...patients also have a problem with their lungs that leads to scarring (fibrosis). This scarring is caused by inflammation, in which an abnormal number of whit...Combating fatigue associated with liver disease
...n inflammation of the bile ducts in the liver that leads to cirrhosis. Fatigue is often associated with depression, which may be caused by abnormalities in serotonin transmission; ondansetron helps regulate serotonin levels, which suggests its potential as a treatment for fatigue and depression. Hepatology...Scientists observe infectious prion proteins invade and move within brain cells
... of Neuroscience. "These findings offer intriguing leads toward developing therapies to stop the spread of TSE and possibly other degenerative brain diseases," says NIAID Director Dr. Anthony Fauci. "Potentially, it may be possible to block the pathways that prions use to invade cells, their exit to other ...Diagnostic imaging in line with other hospital costs
...e said. "As doctors, we like to think that imaging leads to quicker diagnosis and treatment. Our results were encouraging and suggested that more spending on imaging does appear to be associated with a shorter hospital stay." For the study, six groups related by diagnoses--stroke, appendectomy, lung cancer...Fluorescence device to diagnose atherosclerosis and tumors described at optics conference
... plaque that is vulnerable to rupture, which often leads to heart attack or stroke. Recent atherosclerosis research has found that the composition of plaque and its "vulnerability" to rupture may be more significant than the degree of arterial blockage as a precursor to heart attack and stroke. The lipid c...New NIAID grants strengthen national biodefense and emerging infectious diseases research network
...rants to eight institutions. Each institution also leads an RCE consortium made up of universities and other research institutions within its geographic region. The network conducts research that will lead to next-generation treatments, vaccines and diagnostic tools for diseases such as anthrax, plague, sm...ACPM to host web-based conference on adolescent binge drinking
...is a harmful behavior that, in too many instances, leads to tragedy. Clinicians should be able to recognize and provide appropriate treatment for the adolescent who may be engaging in this risky behavior." Information on how to participate in the June 14th web-based conference will be available starting J...Women overestimate breast cancer risk, U-M study finds
...or relatives who have been diagnosed with it. That leads us to overestimate how common it really is. We forget that we know a lot of people with breast cancer because we know a lot of people," says senior study author Peter Ubel, M.D., professor of internal medicine at the U-M Medical School and director o...Mayo Clinic case series illuminates connection between welding, brain damage
...provides further evidence that unprotected welding leads to neurological damage. "An important finding from our case series analysis is that these patients were not only all welders, but all had a lack of ventilation," says Dr. Josephs. "They didn't have a mask or were welding in confined spaces." Dr. Jo...