JCI table of contents: January 19, 2006
... needed). However, the mechanisms by which hypoxia leads to new vessel formation is poorly understood. In the mouse retina specialized cells called astrocytes regulate angiogenesis by producing a structural support protein known as fibronectin during hypoxia, but until now it was unclear what triggered thi...UQ scientist honoured for developing the world's first cancer vaccine
...stomach ulcers. Professor Frazer, who founded and leads UQ's Centre for Immunology and Cancer Research, is also the 2006 Queensland Australian of the Year and is consequently in the running for the Australian of the Year Award, which will be announced at Parliament House on January 25. He said The Austra...Emory study lights up the political brain
...tors hypothesize that emotionally biased reasoning leads to the "stamping in" or reinforcement of a defensive belief, associating the participant's "revisionist" account of the data with positive emotion or relief and elimination of distress. "The result is that partisan beliefs are calcified, and the per...Women with endometriosis undergoing IVF benefit from treatment with GnRH agonists
...ent there is no data showing whether the treatment leads to better eggs or better acceptance of embryos by the lining of the womb," says Sallam. There is also no data to show whether one particular agonist is superior to others, or whether the therapy has differential effects on women with mild or severe e...Hypertension data may mask racial disparities among Hispanics
...there is nothing inherently about being black that leads to higher rates of hypertension," Williams said. "...ople live. "It's the perception of otherness that leads to discrimination and racism," Borrell said. Both researchers explained that in America especially, ...JCI table of contents, January 26, 2006
...omplement to prevent kidney damage Kidney failure leads to the buildup of toxins in the blood. A type of injury known as renal ischemia/reperfusion (I/R) contributes to kidney failure and causes injury to special renal cells called tubular epithelial cells. In mice, acute renal failure (ARF) is associated...Landmark hypertension study launches extensive physician and patient education program
...essure remains out of control. High blood pressure leads to more than half of all heart attacks, strokes, and heart failure cases in the United States each year, and it increases the risk of kidney failure and blindness. Clinical guidelines recommend that physicians work with patients to keep blood pressur...International Journal of Epidemiology obesity special
...ing or energy metabolism in the developing foetus, leads to obesity in later life. Strict glycaemic control during pregnancy could held to prevent this. Adolescence may also offer a unique opportunity to modify the risk of future obesity, perhaps via short-term interventions as behaviours such as dietar...48 hour access target for UK sexual health clinics impossible
...urvey found. A forthcoming survey of sexual health leads in primary care trusts and specialist clinicians, due to be published in the next few weeks, is expected to reveal a similarly gloomy picture. "There is clearly a continued crisis in GUM services in the UK," write the authors. " to neglect this area ...Researchers provide dose of education to lower blood pressure
...essure remains out of control. High blood pressure leads to more than half of all heart attacks, strokes, and heart failure cases in the United States each year, and it increases the risk of kidney failure and blindness. "Possibly, we could save 40,000 to 50,000 serious illnesses per year, including heart ...Gap widens between optimal versus actual cholesterol levels
...from achieving the 2001 goals, and as new evidence leads the NIH to push optional goals down further, the gap between what we believe to be ideal goals and what has been achieved gets even wider," Persell said. Too much LDL-C can build up on the inner lining of arteries that feed the brain and heart, and i...Unique vascular dysfunction in women's heart disease described in major journal supplement
...he arteries, anemia and microvascular dysfunction leads to the possibility that different diagnostic and prognostic tools may be employed. Among options currently being evaluated are high-sensitivity C-reactive protein (a laboratory test that can detect inflammatory processes), hemoglobin monitoring, and ...High blood pressure and kidney disease increase risk for heart disease and stroke in older Americans
... quite sure why moderate and severe kidney disease leads to greater risk in heart disease. "It may be related to other factors associated with renal failure, such as anemia or abnormalities of calcium or phosphorus metabolism, for example. We are participating in other ongoing studies to establish the c...Disposable catheter breakthrough, a world first
...eed. In addition, dampening of the pressure signal leads to under-recording of peak swallowing pressures, so rapid pressure changes are not be picked up instantaneously and the signal may be missed, which could result in a wrong diagnosis being made. "Another significant disadvantage of the catheters is th...First disease-specific (breast cancer) protein library opens new drug paths
...D, who was not part of this research team, and who leads the Proteomics group at the Broad Institute (of Harvard University and Massachusetts Institute of Technology). "While this work is highly in-vitro and needs further validation, the tools and approaches demonstrated in this study show a potentially v...Alzheimer's disease neuroimaging study launched nationwide by National Institutes of Health
...g as baby boomers enter their older years. The NIA leads the Federal effort in research on AD and age-related cognitive change. For more information on participation in a number of clinical studies on AD, visit http://www.clinicaltrials.gov (search for "Alzheimer's disease" trials) or the ADEAR Center we...It's in the genes: Study opens door to new treatment of the blues
...m. The findings of this study provide exciting new leads and point to potential strategies, such as developing drugs capable of targeting specific proteins in restricted brain areas."...Study finds room for improvement in angioplasty, shows what can be done to cut risks
...ays Mauro Moscucci, M.D., the U-M cardiologist who leads the project with BCBSM's David Share, M.D., MPH. "It is crucial that we understand how individual physicians and hospitals vary, and work to reduce that variation so that each patient's care is delivered in a way that reduces risks and complications,...Morphine and topical anesthesia found effective in treating pain in newborn infants
...vidence that untreated procedural pain in newborns leads to long-term changes in pain sensitivity, according to background information in the article. The effectiveness of local or systemic analgesics (pain relievers) to minimize pain in newborns during certain procedures is not clear. Anna Taddio, Ph.D., ...Columbia receives up to $15 million from Spinal Muscular Atrophy Foundation
... nerve cells in the spinal cord. Loss of function leads to premature death due to respiratory problems; half of its victims die before reaching age two. The SMA Foundation estimates that there are currently 25,000 to 55,000 people suffering from SMA in the United States, Europe, and Japan and that the an...