Pathway links inflammation, angiogenesis and breast cancer
...ournal. Inflammation is linked to breast cancer, liver cancer and cancers of the gastrointestinal tract. The research team set out to discover whether angiogenesis - the creation of new blood vessels - plays a role in cancer formation related to the inflammatory protein Tumor Necrosis Factor alpha (TNFa)...Stanford researchers find culprit in aging muscles that heal poorly
...r for that matter, potentially any tissue, such as liver and brain, in which stem cells contribute to normal cellular turnover. Rando and his colleagues made the discovery while studying the effect of environment on muscle stem cell activity in mice. Rando had already discovered that old muscle stem cell...'Heroes of Chemistry' honored for medical, energy, environmental breakthroughs
...asma (unbound) iron -- from key organs such as the liver and heart. Pierre Acklin, Ph.D., was Head, Analytical and Imaging Sciences for the Discovery Technology department at Novartis Institutes for BioMedical Research. He received his Ph.D. from the ETH Zurich, in 1991. He died in April of 2006. ...Penn researchers discover novel pathway for increasing 'good' cholesterol
...School of Medicine have discovered that a group of liver enzymes called proprotein convertases (PCs) may be the key to raising levels of good cholesterol (HDL-C). The pathway by which these proteins are able to achieve an increase in HDL cholesterol involves another enzyme that normally degrades HDL-C, and...Metabolic study in mice could lead to 'good cholesterol' boosters
...at treatments that partially block the activity of liver enzymes called proprotein convertases decreased pl...ncreased activity of proprotein convertases in the liver gives a significant boost to the protective HDL-C. Proprotein convertases are an unexpected new pl...Statin drugs may delay progressive artery damage in children
...of the children in the study suffered increases in liver and muscle enzymes attributed to their medication, a major concern with statins. Two boys had temporary increases in muscle enzymes apparently related to their extreme physical exercise. Four patients complained of muscle pain but had no elevated m...Study shows radiofrequency ablation highly effective in treating kidney tumors
...ys it. The technique has been used successfully in liver tumors since the early 1990s and has more recently been adapted for treatment of RCC. Renal cell carcinomas that are smaller than 3.7 cm in diameter can be reliably and safely eradicated with percutaneous RFA, Zagoria and his colleagues conclu...The Eli and Edythe Broad Foundation invests in gastroenterology's future
...Palo Alto VA Hospital Monitoring of apoptosis in liver diseases with a novel keratin-cleavage specific antibody Alice B. Conant Phillips Andover Academy, Andover, Massachusetts Research location: University of Pennsylvania School of Medicine Association of physical activity and biomarkers on col...UD scientists invent novel hydrogels for repairing, regenerating human tissue
...n at the Helen F. Graham Cancer Center who resects liver tumors. Both Schneider and Pochan attribute this...ences and material sciences at UD. You know, the liver is an amazing organ, Schneider said. It has the ability to regenerate itself quite easily. If almost...UK and other European countries should introduce universal childhood hepatitis B vaccination
...s Europe. Hepatitis B is also the leading cause of liver cancer. Dr Jane Zuckerman, Academic Centre for Travel Medicine and Vaccines, Royal Free and University College Medical School, London, UK and colleagues reviewed vaccination policies in the UK, Ireland, Finland, Iceland, the Netherlands, Norway, S...Low-carb diets' effects linked to rise in newly identified 'starvation hormone'
...se with chronically elevated concentrations of the liver hormone. Kliewers team further showed that the hor...ibuted to a growing epidemic of nonalcoholic fatty liver disease. Although the physiology remained uncertain, pharmacological studies of mice and diabetic mo...Study identifies new regulator of fat metabolism
... 2007 issue of Cell Metabolism, demonstrate that a liver hormone known as FGF21 is required to oxidize fatt.... Consequently, fatty acids are broken down in the liver and converted to ketones, which then serve as a major fuel source. Known as ketosis, this metabol...Liver cancer patients with high serum levels of hepatitis B virus face poorer outcomes
...ic value of serum HBV DNA levels for patients with liver cancer undergoing chemotherapy. They found that pa...ated with a more than 200-fold increase in risk of liver cancer. In areas where HBV is endemic, like China and the Far East, the great majority of cases of h...When HIV and liver disease co-exist
...s B or C are experiencing the progression of their liver disease. In the face of this novel challenge, expe...sts are seeing more infected patients with complex liver issues. To address questions about care for these co-infected patients, an international forum was c...OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
... CRP, is a special type of protein produced by the liver that is elevated in the presence of inflammation. "This could mean that a simple blood test that is already available could help patients and doctors make better decisions as they become more informed about what to expect from the prostate cancer the...Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
...e disorders. The condition affects proteins in the liver that are necessary to process the by-products of protein metabolism. "Historically, the prognosis for patients with urea cycle disorders has been universally poor," said Gregory Enns, MD, director of the biochemical genetics program at Packard Chil...Hepatitis C negatively impacts HIV
...vious research, alcohol use may worsen HCV-related liver disease and interfere with adherence to antiretroviral therapy (ART) and medical care. The researchers studied 396 HIVinfected persons with alcohol problems. Fifty percent (199) were also co-infected with HCV. CD4 cell counts and HIV RNA level...Complications of type 2 diabetes in young people -- a ticking bomb
...y, retinopathy, dyslipidaemia, non-alcoholic fatty liver disease and neuropathy. Psychiatric disorders can also be associated with type 2 diabetes with one in five adolescents in a study from Philadelphia, USA, suffering from conditions such as depression, obsessive-compulsive disorder or one of a range...'Supersize me' mice research offers grim warning for America's fast food consumers
... Tetri, a leading researcher in nonalcoholic fatty liver disease, which can lead to cirrhosis and, ultimate...ri. "We had a feeling we'd see evidence of fatty liver disease by the end of the study," he says. "But we were surprised to find how severe the damage was ...New Mayo Clinic MRI technology enables noninvasive liver diagnoses
... is an accurate tool for non-invasive diagnosis of liver diseases. The findings will be presented this week...stive Disease Week 2007 in Washington, D.C. The liver responds to many diseases that damage its cells by developing scar tissue or fibrosis. MRE uses a mo...