NIAID media availability: Examining genetic variability of malaria parasite offers insight
...hers understand the parasite's evolution and study malarial drug resistance. Two companion studies being published simultaneously include one led by NIAID scientists that identifies new antigens--pieces of the pathogen that are recognized by the immune system. Some of these new antigens may be potential targe...New findings could lead to vaccine for severe malaria
...lopment of vaccines and therapies to combat severe malarial infections. During one particular phase of its lifecycle, the parasite enters human red blood cells, where it produces proteins that attach themselves to receptors in the wall of the blood vessels. This causes the red blood cells to accumulate in or...How bad is malaria anemia? It may depend on your genes
...be most susceptible to this lethal complication of malarial infection and to identify treatments targeted to t...e of diseases, in this case the individual risk of malarial anemia. A number of human proteins, including MIF (which stands for migration inhibitory factor), w...Immune culprit in malaria-associated anemia
... levels influence susceptibility to or severity of malarial anemia in humans. If so, synthetic inhibitors of M... risky) blood transfusions currently used to treat malarial anemia....Identified: DNA that controls the malaria parasite's disguise mechanism
...f the debilitating symptoms that usually accompany malarial infection. Other members of the discovery team are Till Voss, Julie Healer, Allison Marty, Jennifer Thompson and Michael Duffy....GroPep completes final milestone of the path malaria vaccine initiative
...s (MVI) mission is toaccelerate the development of malarial vaccines for the developing world. Malaria kills 7000 people each week and there is no vaccine. MVI Director, Dr Melinda Moree congratulated GroPep on completing this important project milestone. "GroPep has made an important contribution to thequest...New study: Drug combo against AIDS-related infections also prevents malaria
...use of TS prophylaxis might increase the number of malarial parasite strains resistant to SP treatment, thereb...xpecting to compare the success of SP treatment on malarial episodes in both groups. What they encountered, however, was just a single clinical episode of mala...Artemisinin-based therapy may not be the best treatment for uncomplicated malaria in Africa
... at least as good a chance of preventing recurrent malarial infection (defined as either new infections or the previous infection returning) compared with patients treated with artemisinin-based combination therapy. In the sites that had the highest transmission rates the cheaper combination worked better. Th...NIAID scientists unveil mechanism behind resistance to severe malaria
...esulting inflammation may increase the severity of malarial symptoms, explains Dr. Wellems. Dr. Wellems and his colleagues found uneven and reduced distribution of PfEMP-1 on the surface of parasite-infected red blood cells from children with at least one hemoglobin C gene. This abnormal distribution of PfEMP...Reducing malarial transmission in Africa
...dren had gametocytes - the infective form of the malarial parasite - in their blood. The numbers of gametocytes carried and how able they were to infect mosquitoes 7 days later was also reduced by the six dose regimen. Although the results are promising, some patients may have difficulty taking a six-dose r...Anti-malarial drugs given to infants can protect them for two years
...0 months to 2 years from intermittent preventative malarial treatment for infants. This finding increases the potential public-health benefits of such treatment." In an accompanying comment Imelda Bates (Liverpool School of Tropical Medicine, UK) concludes: "Accumulating evidence about the effectiveness and s...