New procedures more accurate in early diagnosis of GI cancers
...rt study consisted of finding potential diagnostic markers and developing and validating a diagnostic model. Researchers analyzed the profiles of 38 gastric cancer patients and 29 healthy control patients and found that the identified fingerprints were significantly more prevalent in the cancer group. Res...Babies' cries linked to their health
...onance and changes in the cry mode were consistent markers associated with SIDS. Resonance is the characteristic of a sound's richness and depth that help humans distinguish a C note on a piano versus a guitar, and mode changes are noisy, broken-sounding cries that indicate poor neural control of the vocal t...American Thoracic Society Journal news tips for May 2005 (second issue)
... doses could be predicted based on two noninvasive markers that could demonstrate lower inflammation levels in the airways. The two markers used and their key indicator levels were: exhaled nitric oxide levels below 22 parts per billion (pp...Mayo Clinic: Biomarker that may improve quality of life during treatment for colorectal cancer
...ed that the variations could be used as biological markers -- biomarkers -- that would indicate which patients are most susceptible to oxaliplatin's negative side effects. Their results confirmed this. Using genetic information from the patient to tailor treatment is referred to as pharmacogenomic medicine, ...Biologic therapies for bowel disease show promise in clinical trials
...ubpopulations, may also be applicable as surrogate markers for the clinical effect of the drug. "The notion of personalized therapy is an exciting new model for treating patients and is especially applicable in Crohn's disease, where a misfiring of the body's immune system is believed to be related to the i...CT colonography 'excellent' for colorectal cancer screening
...noscopy. Several other, more clinically relevant, markers of diagnostic accuracy also showed a trend of excellent accuracy. "The single biggest obstacle to colorectal cancer screening remains patient compliance. An alternative tool such as CT colonography, which offers similar accuracy as conventional colon...Biomarkers for interstitial cystitis identified, could lead to the first test
...ers used a proteomic approach to identify specific markers related to IC. By comparing protein expression in the bladder tissue of two animal models of IC to expression in the tissue of a normal animal, the researchers found three nuclear proteins that were unique to the animals with IC. Using protein mass f...Psychologist: Make culture part of the new collaborative science
...ing in the U.S. is directly linked with biological markers such as stress cortisol levels and cardiovascular risk. Now, expanding the work through a proposed study called MidLife in Japan (MIDJA), Ryff wants to learn how varied cultures harbor different notions of well-being, and how those notions might int...New insights into role of tumor necrosis factor on sex hormone production in rheumatoid arthritis
... a negative correlation between converted DHEA and markers of inflammation among RA patients but not in patients with OA. They also found evidence that TNF inhibits the activity of steroid sulfatase, the key enzyme in DHEAS-to-DHEA conversion. ...Test accurately predicts aggressiveness of breast cancer
...Giovannini said. "All these factors are well-known markers of poor prognosis." The same findings were valid also when the 'pT1' subgroup of the very earliest stage cancers was considered. "This means that very early invasive breast cancer gathers very different tumors in terms of prognosis and Ki67 could be ...3D atlas will help navigate the spinal cord
...l be based on a comprehensive use of neurochemical markers (chemoarchitecture). Many pathways in the nervous system contain a particular protein which can be demonstrated in tissue sections using a technique called immunohistochemistry that involves the use of specific antibodies. The often distinct distri...Variations in four inflammatory genes may predispose Mexican Americans to insulin resistance
...stance, as well as that between these inflammatory markers and the later development of Type 2 diabetes, may well have a genetic basis encompassing such inflammation genes as IL4, IL4R, IL5 and C5," Rotter said. Future studies will investigate the role these genes play in the development of insulin resistan...Teen-agers with Type 1 diabetes already developing cardiovascular disease
...man noted that researchers also tested for certain markers in the blood that are related to inflammation of t...hers found no relationship between levels of these markers and IMT in the teen-agers. Researchers also are unsure why the teen-age girls with type 1 diabetes f...News briefs from the journal CHEST June 2005
... a worsening of bone-related hormones and turnover markers without recovering bone mass. The most significant improvements in BMD were in the 19 patients who underwent surgery and quit oral steroids. The 21 other patients who underwent surgery but continued taking oral steroids also experienced improvements ...Novel approach for eradicating prostate cancer wins award for young Hebrew University researcher
...te cells. This makes it very difficult to identify markers that would allow targeted treatment of tumor cells alone. Among the cells in the immune system that protect against the growth of tumorous growths are the natural killer (NK) cells, which are able to identify and kill different tumor cells. This abi...Researchers shed new light on cause of bedsores and other chronic wounds
...dge of the wound that do not have these pathogenic markers or have very little are the million-dollar cells, which you really want to target in therapy," says Dr. Tomic-Canic. The findings may also be useful in clinical trials of new therapies for chronic wounds, to make sure that the treatments are targe...Georgetown cancer researchers develop high throughput method
...ry of new diagnostic markers," LeBaron says. "Such markers will allow more accurate patient diagnosis and predict outcome more effectively, and ultimately tailor treatments to an individual's disease." "In addition to tumor analyses, CEMA arrays will be useful for large scale studies of whether drugs or envi...A study on markers of inflammation in smokers and non-smokers shows t...ormal after smokers quit than did more traditional markers of cardiovascular risk such as total cholesterol, high-density lipoprotein cholesterol, triglyceride...Weight-loss surgery produces unexpected drop in heart disease risk, Stanford researchers find
...ts of the surgery on all three newer heart-disease markers - C-reactive protein, lipoprotein A and homocysteine, Williams said. They set out to study the effects and found improvements across the board. "All of the values improved to where they were no longer in the abnormal range. In other words, they norm...Study links adolescent IQ/activity levels with risk of dementia
... According to Fritsch, "Our findings confirm that markers for dementia risk can be found early in life. However, while our research implicates a role for IQ and activity level in youth, many other factors, alone or in combination, also influence who will and will not develop dementia. As we know, some very ...