Aggressive stem cells might improve transplant outcome
...ancer cells, and they develop a specialized homing mechanism called a T cell receptor that lets them find the specific target they are genetically programmed to attack. The key to the new finding is the discovery by the St. Jude team that the antibody currently used to seek out and "capture" CD34+ stem cells...New Inteleos features gives users the ability to tailor information
...ugs per therapy area and allows for comparisons by mechanism of action or drug class, creating dynamic results instantly. Using information reported by ClinicalTrials.gov users can identify and analyze clinical trials across industry, government and academia. Users can also view key trial details specific to d...Psychologist to study how we put stress into words
...question. He is leading a new project to study the mechanism of language processing that governs how stress is ...th Wales, Australia, he will examine what role the mechanism plays in learning to read. The research, which is supported by the Economic and Social Research Coun...Extra payments to Medicare Advantage plans totaled $5.2 billion over fee-for-service costs in 2005
...rnative to the ineffective sustainable growth rate mechanism currently used to determine the physician payment update; or reduce the increase in the Part B premium in 2007 by about $10 per month for each beneficiary. "While encouraging enrollment in private plans was billed as a way to reduce costs for th...Autoimmune disease triggered if T cells miss a single protein early on
...antigen can trigger disease," he added. A similar mechanism may be at play involving other autoimmune diseases such as type 1 diabetes, Anderson said. Immunologists have demonstrated that insulin is expressed in the thymus not just in the pancreas. Studies have shown that people who are protected from diab...Report card on Vancouver's safer injecting facility
...vices. The program has acted as a central referral mechanism to a wide range of other community resources. In a related commentary, Wainberg calls on the federal government to continue its support of Vancouver's safer injecting facility and questions its recent decision to eliminate the funding needed for a...Targeted cancer drugs may work by disrupting balance of cellular signals
...ene addiction." Better understanding these drugs' mechanism of operation could help surmount current limitatio... yet researchers have not understood the molecular mechanism underlying these drugs' activity, information that might expand their usefulness to a broader patien...New study on school bus safety shows injuries well exceed previous reports
...ndicate that motor vehicle crashes are the leading mechanism of nonfatal school bus-related injury for children in the U.S.," said CIRP Director Gary Smith, MD, DrPH, one of the study's authors and a faculty member of The Ohio State University College of Medicine. "In addition, this study identified several ot...Mayo Clinic Cancer Center prostate SPORE grant renewed
...nical research studies evaluating a viral delivery mechanism for radioactive iodine to safely and effectively treat prostate cancer Administering clinical studies to determine the safety and effectiveness of the allogeneic prostate cancer whole-cell vaccine; and also a topical vaccine derived from prostate...Interaction between lymph and liver cells may affect immune response
...at such interactions do occur and demonstrated the mechanism by which they may take place. The results may help explain the altered immune responses that occur with aging and other conditions and may be useful in developing therapies for viral hepatitis and autoimmune diseases. The results of this study appe...Drug prescribed for migraines and seizures increases risk of kidney stones
...Southwestern researchers said. More important, the mechanism of stone formation was largely unknown previously. "The wide-spread and escalating use of topiramate emphasizes the importance of considering the long-term impact of this drug on kidney-stone formation," said Dr. Khashayar Sakhaee, senior author of ...Drug combo improves survival in patients with COPD
...istically significant. "We do not know the exact mechanism by which this combined therapy works better than the separate therapies. We speculate that synergistic action on cell receptors may lead to less muscle contraction or inflammation," said Dr. Celli. "Although we do not expect the combination therapy t...Researchers discover mechanism that determines when detailed memories are retained
...y published in 2005, he discovered a neural coding mechanism that the brain relies upon to register the intensity of memories based on the importance of the experience. The study presented the first evidence that a "memory code" of any kind may exist. His laboratory also was the first to induce a specific memo...New mechanism underlying pain found
...nnounced that they have discovered a new molecular mechanism that may underlie neuropathic pain. The clearer un..., but the better understanding we've gained of the mechanism can enable us to narrow our focus."...Key gene controlling kidney development found
...e in the developing kidney suggests that a similar mechanism exists in other developing organs," said Michelle Self, the doctoral student in Oliver's laboratory who did most of the work on this project. The St. Jude team showed that the kidneys in developing mice lacking the Six2 gene were remarkably smaller t...Dopamine imbalances cause sleep disorders in animal models of Parkinson's disease and schizophrenia
...of neuroscience. The findings may also provide a mechanism to explain some of the symptoms, such as hallucinations, experienced by psychotic and schizophrenic patients, he said. The researchers published their findings in the Oct. 11, 2006, issue of the Journal of Neuroscience. The work was supported by th...Cincinnati Children's researchers publish findings on potential target for leukemia treatment
...ng research identifying the crucial role and novel mechanism of action of the protein RhoH GTPase in the develo...t. In addition, the researchers uncovered a novel mechanism for regulating RhoH activity, which may have broad implications in improving researchers' understand...Study identifies possible mechanism for brain damage in Huntington's disease
...nerative Disease (MIND) have identified a possible mechanism underlying how the gene mutation that causes Hunti...ging theme in neurodegenerative disorders, but the mechanism behind HD has been elusive." HD causes the degeneration and death of cells in the basal ganglia a...Penn researchers find Lou Gehrig's, FTD disease protein
... Aging at Penn. Misfolded proteins are a common mechanism in neurodegenerative diseases. The misfolded proteins are tagged for recycling by the cell with another protein called ubiquitin. However, in neurodegenerative diseases these tagged proteins aggregate in the neurons of the brain and spinal cord and a...Blood cells linked to heart attacks, other inflammatory diseases
...rosis and heart attack. Discovery of the signaling mechanism will be invaluable in sorting out the roles Cox-2 ...hes that turn Cox-2 production on and off. "It's a mechanism for precise control of Cox-2 production," he said. "But if one of the switches is turned on too high...