Carnegie Mellon receives NIMH/NSF grant to examine mechanisms that underlie neuronal synchronization
...rom his discovery of stochastic synchrony, a novel mechanism for generating synchronous neuronal firing. With t...hniques, we have described stochastic synchrony, a mechanism by which neurons are synchronized by random, 'noisy' inputs," Urban said. "We are now investigating ...Drug can quickly mobilize an army of cells to repair injury
...n," he says. "That way you enhance a normal repair mechanism instead of using the brute force of injecting a mixture of many cell types from bone marrow into the affected area." The research group has also shown that after treating human subjects with AMD3100 or G-CSF, angiogenic cells can be collected from t...Bone mass continues to increase in liver transplant patients, despite early loss
...re bile production stops). However, the underlying mechanism of bone loss in these patients is poorly understood and osteoporosis is often overshadowed by the more pressing health problems seen with liver disease. Early aggressive bone loss occurs in almost all patients following transplant, and although immun...Study uncovers mechanism of drug resistance in form of lung cancer
...atients than previously thought have this as their mechanism of resistance," says Jnne. "Identifying those patients will be important in the next generation clinical studies of drugs for NSCLC, which accounts for about 85 percent of all cases of lung cancer in the United States." Iressa and Tarceva are used ...New cell-based targets for treating autoimmune inflammatory diseases
...rreversible, and fatal. Little is known about the mechanism behind this crescent or its relationship to immune-mediated inflammation. To gain understanding, a team of researchers in Japan began by analyzing a spontaneous mutant strain of EOD mice. Their study, published in the September 2006 issue of Arthr...Researchers identify antibiotic protein that defends the intestine against microbial invaders
... infections. "We are now working to understand the mechanism by which the intestinal lining senses bacterial threats. What turns this protein antibiotic on?" Dr. Hooper asked. "We want to explore whether this is something we can stimulate artificially to stave off pathogenic infections."...Scientists stop autoimmune disease without shutting off immune system
...eviously shown an enzyme called p38 is part of the mechanism by which pemphigus vulgaris autoantibodies cause damage. Autoantibodies are immune-system cells that attack the body's own tissues. In a mouse model of pemphigus vulgaris, the researchers prevented blistering and other signs of the disease by inject...Venous thrombosis after travel
... is highly increased. The study could not show the mechanism of the increased risk, although the association of thrombosis with all types of travel, not just air travel, suggests that immobility is a key factor. Other mechanisms, such as reduced oxygen levels triggering clotting, may be involved in the particu...First study to show how immune cells 'speak' to each other in vivo
...dy can be accessed at www.jem.org . WHY: The mechanism of how immunological synapses "speak" to each other in vivo has not been observed prior to this research. Although formal proof of this awaits the development of drugs or mutations that interfere selectively with synapse formation, the confirmation ...Mapping the neural landscape of hunger
...s separate hunger phases might constitute a neural mechanism underlying meal initiation under different peripheral and metabolic environments," they wrote. ...Boosting key protein in brain could improve seizure treatment, Stanford study finds
... first author. Although there may be more than one mechanism by which our brains stop seizures, an increase in neuropeptide Y is clearly one of them, he said, and he and Brill are already exploring other ways to trigger production of the peptide and prolong its action. The precise nature of this response to ...Updated International AIDS Society guidelines recommend new goal of undetectable viral load
...otease inhibitor (darunavir) and a drug with a new mechanism of action (such as FUZEON) added to a background of an optimised antiretroviral regimen. This strategy is not only recommended by the IAS-US panel guidelines published this week but also by the US Department of Health and Human Services (DHHS) guidel...Clinical trial evaluates first-line approaches for treating HIV
... reverse transcriptase inhibitors, target the same mechanism but block the reverse transcriptase enzyme by attaching to a different site than NRTIs. The class of drugs known as protease inhibitors blocks the maturation of proteins that HIV needs to assemble itself into an infectious virus. ...JCI table of contents: August 10, 2006
...interferon-gamma acts as part of a self-regulatory mechanism to help keep the immune response in check by triggering the development of Tregs. This mechanism likely plays a role in other pathological conditions involving inflammation. TITLE: Role of IFN-ga...Arthritis drug helps debilitating inflammatory disease
...uller life than previously possible." While the mechanism of NOMID is not completely understood, research in...but it also provides a better understanding of the mechanism of the disease's damaging effects." Furthermore, notes Goldbach-Mansky, anakinra was safe in this...Medscape review supports effectiveness and safety of new non-drug blood pressure treatment
... effects. The study also reviews the physiological mechanism of action of device-guided breathing. A summary of the results of the seven studies shows an average all-day reduction of 14/8 mm Hg within four to six weeks of commencement of 15-minute-daily treatments with RESPeRATE. The reduction in blood pres...Humanitarian response urgently needed to address Lebanese health crisis
...ire. Development and health experts could create a mechanism to coordinate the complex array of international organisations working in Lebanon. They can sharpen legal instruments to protect humanitarian corridors. And they can leverage funding to meet the UN targetsWestern governments are willing to allow civi...Brain chemical plays critical role in drinking and anxiety
.... "Our study suggests a molecular, neurochemical mechanism in the amygdala which may be responsible for the association of high levels of anxiety with excessive alcohol-drinking behavior," he said. ...Smoking out the links between nutrition and oral cancer
...," Johnson says, "but perhaps this is a protective mechanism in which one form of the antioxidant vitamin goes up when another goes down." The authors note that epidemiologic observations show that smokers tend to eat diets lower in fruits and vegetables than do non-smokers. However, in both the folate study......and escalator-related injuries." The most common mechanism of injury for all age groups was a fall, which accounted for more than half of the injuries. Entrapment accounted for 29 percent of injuries, and the leg was the most frequent (28%) site of injury for all age groups combined....