Drug prescribed for migraines and seizures increases risk of kidney stones
...term basis, or for about one year, caused systemic metabolic acidosis a buildup of excessive acid in the blood as a result of the inability of the kidney to excrete acid. Topiramate use also increased the urine pH and lowered urine citrate, an important inhibitor of kidney-stone formation. "These changes in...Stress triggers relapse in meth abuse, OHSU study finds
... a compound researchers used in the study to mimic metabolic changes that occur during periods of stress create...for reinstating drug-seeking behavior." And as a metabolic stressor, 2-DG is innocuous enough to be used in research on both animals and humans, Mark added. "Y...Study identifies possible mechanism for brain damage in Huntington's disease
...f PGC-1a knockout mice found decreased activity in metabolic pathways known to be involved in mitochondrial function pathways also downregulated in human HD and brain samples from HD patients also showed reduced expression of mitochondrial genes. Within the striatum HD causes degeneration of medium spiny n...Leptin has powerful effect on reward center in the brain
...chool of Medicine study in Neuron. "Finding that metabolic hormones directly regulate the ventral tegmental a...ations for how researchers view the integration of metabolic signals in the brain," said the senior author, Ralph DiLeone, assistant professor of psychiatry. ...Rochester launches Cancer Stem Cell Research Program
...ong with about 25 scientists studying the genetic, metabolic and neurologic aspects of cancer stem cells. If scientists and doctors better understand the growth and survival of cancer stem cells, it could change beliefs about how cancers spread and how tumors should be treated. The biological problem caused...Researchers use statistical technique to find mix of biomarkers predicting mortality
...uroendocrine and vascular functions and immune and metabolic activity over 12 years in 1,189 high-functioning men and women aged 70-79 enrolled in the MacArthur Study of Successful Aging. The goals were to identify biomarker combinations (or high-risk pathways) associated with high levels of mortality in men a...UC Davis researchers find added benefit of statins in those at high risk for heart disease, diabetes
...duce disease-causing inflammation in patients with metabolic syndrome -- a condition defined by symptoms that i... offers new hope to the one in four Americans with metabolic syndrome who have double the risk of developing heart disease and are five times more likely to deve...Before dementia's first signs appear, weight-loss rate doubles in elderly
...is first evaluation when they had mild dementia, a metabolic process kicked in, or kicked into higher gear, and made their Alzheimer's detectable. And increased weight loss went hand-in-hand with that change."...Anti-inflammatory drug prevents liver cancer in at-risk liver patients
...iruses B and C are also major risk factors, as are metabolic diseases that affect the liver. Liver disease has a wide clinical spectrum, from mild abnormal lab results to irreversible fibrosis of the liver. Much of the damage to the liver is caused by inflammation, which can be caused by acute or chronic toxin...Methamphetamine use restricts fetal growth, study finds
...ren are more likely to develop type 2 diabetes and metabolic syndrome, a collection of heart attack risk factors such as high blood pressure and obesity. "We're also very concerned about the developmental implications," said Lester, a professor of pediatrics and psychiatry and human behavior and director of ...New research could help women facing high risk of stillbirth
... the hormonal metabolism of pregnant women and the metabolic signals between mother and fetus. They particularly looked at a key signalling molecule, mainly produced by fat cells, called adiponectin. This is known to have anti-diabetic properties as well as anti-inflammatory and anti-atherogenic actions (it pr...More aggressive treatment warranted in patients with metabolic syndrome
...terol in patients with coronary heart disease and metabolic syndrome, a syndrome composing of three cardiovasc...a, San Francisco, USA) involved 5584 patients with metabolic syndrome and clinically evident coronary heart disease aged 35--75 years. The patients were random...Licensing arrangement reached for antiepileptic drug
...esirable side effects which may be caused by toxic metabolic substances (metabolites). The new CNS drug, valrocemide, is a combination of a known antiepileptic drug, valproic acid, and a glycine derivative, glycinamide. Valrocemide has been shown to be one of the most effective drugs among a large, analog...Pall system to detect blood bacteria given CE mark
...ncreasing amount of oxygen is consumed through the metabolic activity and proliferation of the bacteria during incubation, resulting in a measurable decrease in oxygen content. The study presented to the ISBT tested the Pall eBDS on 662 red blood cell samples that had been inoculated separately with twelve dif...Penn researchers to get 7 Tesla whole-body MRI system
...l neuroscience, the study of neurodegenerative and metabolic disorders, molecular imaging for cancer detection and treatment monitoring, novel approaches to cardiovascular disease and tissue perfusion, arthritis and osteoporosis. This ultra high-field magnet facility will also serve as open resource for the en...A little TLC goes a long way toward reducing high cholesterol
...A special section of the booklet is devoted to the metabolic syndrome, a cluster of risk factors for heart dise...'s risk of heart disease, but having several as in metabolic syndrome increases risk even more. The lifestyle changes recommended in the TLC program especially...Metabolic disorder not well-suited for inclusion in newborn screening programs
A metabolic disorder that can lead to developmental delay and other problems is more common than previously assumed, but does not meet major criteria for inclusion in newborn screening programs at this time, according to a study in the August 23/30 issue of JAMA...Acne medication associated with abnormal blood test results
...de levels are at risk for high cholesterol and the metabolic syndrome, which in turn may increase the risk for coronary artery disease; further study is needed regarding these side effects, the authors write. (Arch Dermatol. 2006;142:1016-1022. Available pre-embargo to the media at www.jamamedia.org .) ...Mapping the neural landscape of hunger
...ferentially responsive to particular phases in the metabolic status of the animal as it went through a hunger-s...ons are preferentially responsive to variations in metabolic status, neural ensembles appear to integrate the information provided by these neural sensors to mai......et of many age-related diseases like osteoporosis, metabolic syndrome, Alzheimer's disease and major depression. But, she added, certain behavioral factors, like lifestyle and exercise can modify some of these hormonal effects that seem to accelerate aging. Compared to healthy older adults under 100 years of...