JCI table of contents: August 10, 2006
... The factor has two faces: dual role for FoxO1 in metabolic disease Insulin controls in part how we metabo... that is commonly observed in individuals with the metabolic syndrome. The study also suggests that Trb3 is an exciting new target of insulin action and therefor...Exercise important in reducing size of abdominal fat cells
...a pear shape). Abdominal fat is associated with metabolic syndrome, a cluster of symptoms that increases the risk for heart disease and diabetes. The syndrome is diagnosed when someone has at least three of the following: abdominal obesity, high triglycerides, low levels of high-density liprorotein ("good")...Gout increases risk of heart attack, according to University of Pittsburgh study
...ependent risk factor of heart attack. Gout is a metabolic disease marked by acute arthritis and inflammation...n explained by well-known links to renal function, metabolic syndrome, diuretic use and the traditional cardiovascular risk factors," said Eswar Krishnan, M.D., ...Scripps research scientists test anti-obesity vaccine
...n promotes weight gain and fat storage through its metabolic actions, decreasing the breakdown of stored fat for energy as well as curbing energy expenditure itself. During periods of weight loss, such as dieting, the body produces high levels of ghrelin to slow down fat metabolism, encourage eating, and promo...Message to older adults: embrace, don't fear the effects of sensible exercise
...e than 20 percent the number of people who develop metabolic syndrome, a clustering of three or more risk factors for developing heart disease, diabetes and stroke. Risk factors include high blood pressure, elevated blood glucose levels, excess abdominal fat and abnormal cholesterol....Penn researchers calculate how much the eye tells the brain
... brain uses the sluggish channels and pays a lower metabolic cost." "In terms of sending visual information to the brain, these brisk cells are the Fedex of the optic system, versus the sluggish cells, which are the equivalent of the U.S. mail," notes Sterling. "Sluggish cells have not been studied that clo...W.M. Keck Foundation announces 2006 class of Distinguished Young Scholars in Medical Research
...lead to improved treatments for diabetes and other metabolic disorders, such as those associated with HIV infection and protease inhibitor drug treatment. Russell DeBose-Boyd, Ph.D., Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas - Dr. DeBose-Boyd studies an en...Protein potentially links diet, obesity and asthma
... additional intriguing link between the immune and metabolic systems. The study will appear online on July 13 in advance of print publication in the August issue of the Journal of Clinical Investigation. The "hygiene hypothesis" currently dominates thinking in the medical field about the underlying causes of ...A new guideline for screening apparently healthy individuals to prevent a heart attack
...roup of the SHAPE Task Force. Atherosclerosis, a metabolic and inflammatory disease that causes plaque build up in arteries, is responsible for nearly all cases of heart attack and most cases of strokes. Individuals with the highest degree of atherosclerotic plaque burden are described as "the Vulnerable Pat...Most effective antipsychotic drug has serious health consequences
...psychotic drug, have significantly higher rates of metabolic syndrome, according to a first-of-a-kind study by ... More than half the clozapine patients studied had metabolic syndrome while only about 20 percent of those in a comparison group did, researchers report in the J...Aspirin and other NSAIDs may not reduce the risk of colorectal cancer in long-term smokers
... cigarette smoke contains hundreds of carcinogenic metabolic products that may damage DNA. "This accumulated damage might not be reversible," Chia said. "NSAIDs act to suppress inflammatory processes and may help limit the progression toward cancer. However, people who have microsatellite-unstable tumors may b...New scoring system predicts gastric bypass surgery risk
...from conditions such as hypertension, diabetes and metabolic disorder, which can add to the risks of surgery. Hypertension. Patients with hypertension typically have heart disease or chronic inflammation of blood vessels, which might add to the risks of surgery. Pulmonary embolus risk. This variable measures...Production of key Alzheimer's protein monitored for first time in humans
...y potential Alzheimer's patients on the basis of a metabolic imbalance between Abeta synthesis and clearance rates," Bateman says. The test combines technologies that have been available for some time but only through recent technical and procedural advances has become sufficiently sensitive. Via an intraveno...... College, Messina started working with the "master metabolic hormone" insulin, he said. He's been hooked ever since. Rather than focusing on diabetics, however, the endocrinologist has studied the effects injuries have on the body's insulin levels and how those levels in turn affect a patient's chance of survi...Hormones could be prescription for living longer
...in the arteries, collectively known as symptoms of metabolic syndrome. The study, which was conducted by Agni...bese women, who, as expected, had more evidence of metabolic disturbances, the centenarians had significantly fewer signs of hypertension and other symptoms char...Few young competitive athletes survive sudden cardiac arrest
...uration and intensity of exercise prior to arrest, metabolic and physiologic adaptations during exercise and vascular changes are other potential factors that may have affected survival. Dr. Drezner emphasized that improved emergency planning with training in CPR and access to AED's is critical to saving lives...Behavioural therapy can restore ovulation in infertile women
...uced ovulation, it is not enough simply to address metabolic sources of stress." Professor Berga told the confe...arian axes appears to occur independently of major metabolic changes such as an increase in leptin or thyroxine (a hormone that affects how cells use energetic c...Lowering of blood pressure achieved through use of hashish-like drug
...els as the result of hypertension, and others with metabolic irregularities. Maor already has won international recognition for his work with cannabanoids, resulting from his collaborative work with Garry Milman, another Ph.D. student in the laboratory of Prof. Mechoulam, for the discovery of an endogenous co......was also closely associated with components of the metabolic syndrome, including increased body mass index, waist-to-hip ratio, serum triglyceride levels, and systolic blood pressure, as well as decreased levels of high-density lipoprotein (HDL), or good, cholesterol. The study was then extended to subjects w...Meditation may improve cardiac risk factors in patients with coronary heart disease
...onary heart disease, including those linked to the metabolic syndrome, has not been thoroughly examined. The metabolic syndrome refers to a cluster of symptoms that increase cardiac risk, including high blood pressure (...