Drug shows activity against brain metastases
...inib shrank tumors and slowed progression of brain metastases in some patients with advanced breast cancer, acco... alone, has modest but real activity against brain metastases in women who have had multiple prior treatments for their breast cancer, said Dana-Farbers Nancy Lin...Genetic markers in surrounding tissues linked to breast cancer tumor grade, presence of metastases
...mosome 11) and the presence of regional lymph node metastases (chromosomes 1, 2, 5, 18, 20, and 22)," the authors write. "These results support a model in which genetic changes in both stromal and epithelial compartments occur during tumorigenesis, and progression is codetermined by local interaction between ...Radiofrequency ablation effective treatment for inoperable lung cancer
...cancers, including 116 primary lung cancers and 73 metastases to the lung from other cancers. The majority of the patients, who ranged in age from 17 to 94, also suffered from severe cardiopulmonary disease. The one, two, three, four and five-year survival rates for stage I, non-small cell lung cancer treated...Lung cancer screening regimen provides opportunity for cure
...the repeat rounds of screening) had no evidence of metastases when recommended for biopsy, indicating that a regimen of annual repeat screenings allows for detection of lung cancer at its earliest, most treatable, stage. Long-term follow-up, as shown in an International ELCAP study recently published in the New...Study examines genetic factors associated with head and neck cancer
... "hot spots") were positively correlated with node metastases and clinical stage. "Stroma-specific genetic alterations are associated with smoking-related head and neck SCC genesis," the authors write. "We hope that our genomic observations, which point to genomic regions that may harbor many genes, will guide...USC researchers discover breast cancer stem cells in bone marrow
... that only the stem cells have the ability to form metastases in experimental models. What was surprising to Cote and his colleagues, who anticipated some stem cells within the disseminated tumor cells, was that the majority of the remote tumor cells have the stem cell characteristics, and that they appeare...Imaging technique helps predict breast cancer spread before surgery
...nt, meaning that 60 percent of those with axillary metastases were identified; a specificity of 100 percent, meaning that no one without metastases was identified as having metastases; and a positive predictive value--or proportion of patients with...New objective criteria improve PET scan reliability in detecting breast cancer metastasis
... PET scans for invasive breast cancers and their metastases are performed after injection of a glucose-like su...hold set at 2.3, 60 percent of those with axillary metastases were identified (60 percent sensitivity), there were no false positive readings (100 percent specifi...Experiments with fruit quality improvement lead to new approach for halting spread of cancer cells
... supplies, thereby halting its growth and stopping metastases (spread of cancer cells to other parts of the body...hibited the growth of colon cancer-derived tumors, metastases and blood vessel formation. These promising discoveries were detailed in the Cancer article. The ...Mouse model aids discovery of novel melanoma metastasis gene
...cause primary skin melanoma doesn't kill patients metastases are the major problem. So understanding the events that drive metastasis may lead to identifying the most relevant targets for therapy, and potentially, for preventing metastasis." More than 62,000 cases of melanoma will be diagnosed in the United...New test detects prostate cancer spread at the earliest time
...rent trials are also using the test to find hidden metastases in lymph nodes and bone marrow for breast and lung... disease." But a proportion of these patients have metastases of the prostate cancer appear later, even when the lymph nodes removed at the time of the cancer sur...Drug attacks prostate cancer in mouse model by destroying its blood supply
...otherapy paclitaxel to slash the incidence of bone metastases and the size of tumors in mice injected with a mul...t a tumor die swiftly once in circulation and that metastases originate from less than 1 percent of a cancer's cells and even can arise from a single cell. When t...Study compares treatment options for patients with brain metastases
...ing to a study in the June 7 issue of JAMA. Brain metastases (lesions in the brain due to spread of cancers occurring elsewhere) occur in 20 percent to 40 percent of all patients with cancer and are generally associated with a poor prognosis, according to background information in the article. It has been beli...Obesity linked to all types of breast cancer
...hree times more likely to have regional or distant metastases than women with less weight gain. The study is the first to investigate the relationship between weight gain and type of breast cancer. Breast cancer risk is linked to increased lifetime levels of circulating estrogen. Fat tissue increases circulatin...Choice of chemotherapy before liver metastasis surgery matters for some patients
...r Center in Houston. While surgery to remove liver metastases also has proven beneficial, both of the most commonly used chemotherapy drugs to treat these tumors can seriously injure the liver the researchers report in the May 1 issue of the Journal of Clinical Oncology. Furthermore the damage caused to the liv...Pregnant women should not ignore breast cancer symptoms
..., and the remaining woman had stage IV cancer with metastases to the liver. Young women of child-bearing age do not typically have routine mammograms, so a growing cancer may not be found by the patient or her physician until it has progressed to a more serious stage. Because of the advanced stage of cancers in...Tumor size related to lung cancer spread
... "Most lung cancers without evidence of lymph node metastases are curable, with the curability rate being higher at smaller sizes. This suggests that tumor diameter also serves as a prognostic indicator for curability, perhaps even for micrometastases not detectable by our current techniques."...Loss of caspase-8 makes neuroblastoma more aggressive
...into other adult laboratory models, they generated metastases to the ovary, adrenal glands, kidneys and liver. These metastases have lost expression and activity of caspase-8. These findings suggest that the loss of caspase-8 ex...Radiotherapy advance points way to noninvasive brain cancer treatment
... pain-free, since this tumor does not form painful metastases in other parts of the body," says De Stasio. The therapy, called Gadolinium Synchrotron Stereotactic Radiotherapy (GdSSR), requires a gadolinium compound to find tumor cells and penetrate them, down into their nuclei, while sparing the normal brain. ...Precision radiation therapy yields rare success for liver tumors
...apy has not been a recommended treatment for liver metastases because of the poor results when whole-liver radiation was used," said Alan Katz, M.D., M.P.H., lead researcher and assistant professor of Radiation Oncology. "High-dose, precision radiation therapy is proving to be a promising therapy for metastatic...