Angiogenesis factor may help tumors prepare the way for spread to lymph nodes
...ctively modify the 'soil' and prepare it for later metastatic arrival." While it is now accepted that tumors ca...ers of both blood vessels and lymphatic vessels in metastatic nodes of the transgenic mice, compared with cancer-containing nodes in normal mice. In addition, th...More evidence suggests statins help cut risk for advanced prostate cancer
...rious type of advanced prostate cancer - fatal and metastatic (206 of the 283 men). "And the longer men used cholesterol-lowering drugs, the lower their risk," she added. By the end of the study, more than 90 percent of men taking cholesterol-lowering drugs opted for statins, as opposed to other cholesterol-lo...Used in a new way, RNA interference permanently silences key breast cancer gene
...njection or at distant sites typically involved in metastatic breast cancer in this mouse model. Arlinghaus poin...ause of the many problems associated with treating metastatic breast cancer. But he says that proof that RNAi can be used to permanently silence such critical gen...Jefferson scientists create plant factories churning out antibodies against tumor cells
...rectal cancer cells and have been used in treating metastatic disease and in preventing recurrence in certain high-risk patients. But the technology to produce large amounts of antibody is expensive, and researchers would like to find alternatives. Dr. Koprowski, Dr. Ko and their co-workers had previously shown...Other highlights in the May 4 JNCI
...sis in a disease that is typically diagnosed after metastatic spread has already occurred. Contact: Article: NCI Press office, ncipressofficers@mail.nih.gov ; 301-496-6641 Editorial: Karen Carter Mallet, Fox Chase Cancer Center, k_carter@fccc.edu , 215-728-2700 Plasma Levels and Intake of B Vitamin May Be...Molecular change occurring during brain tumor progression also evident in breast cancer
...-8 gene. "Like malignant brain tumors, primary and metastatic breast tumors depend on angiogenesis, the tumor-driven creation of new blood vessels. Now we have found that similar molecular changes happen in highly vascular and invasive tumors such as breast and brain cancers," said Julia Y. Ljubimova, M.D., Ph....Untreated low-grade ductal carcinoma in situ poses long-term risk
... the DCIS biopsy. Five of these 11 women developed metastatic disease as late as 29 years after the original DCIS biopsy and died within seven years of IBC diagnosis. The authors conclude, "Even low-grade DCIS, left without further treatment, predicts for a regional risk and will eventuate in invasive carcinoma...Study finds Herceptin may have role in bladder cancer treatment
...nning, I think this trial provides an approach for metastatic bladder cancer that has not been previously explored. This opens up the possibility of targeted therapies for bladder cancer," says Maha Hussain, M.D., professor of internal medicine and urology at the U-M Medical School. Hussain will present the fin...New kidney cancer drug response rate is more than double that of standard treatment
...ted a response rate of 40 percent in patients with metastatic (advanced) renal cell (kidney) cancer who received...sponse rate." In the first trial, 63 patients with metastatic renal cell carcinoma, whose cancer had failed to respond to standard therapy, received SU11248. Twen...Molecular testing in patients with rare cancer predicts response to Gleevec
...articularly to the liver. Without Gleevec, at this metastatic stage the disease is rapidly fatal because chemotherapy, radiation and surgery are ineffective in advanced cases. Gleevec works by inhibiting a protein called KIT, which is abnormally expressed in GIST and fuels tumor growth by signaling cancer c...Multiple views from CT scans may improve diagnosis
...ultiple views allowed the physicians to diagnose a metastatic tumor that might otherwise be confused with part of the primary kidney tumor. "In the traditional axial view, the tumor looked like it was arising from the kidney, but using the three views, we saw it was actually involving the adrenal gland," he sai...New preoperative chemotherapy and radiation regimen yields encouraging results for sarcoma
...d a local recurrence, three patients had developed metastatic disease and two patients subsequently died from metastatic disease. "We found this aggressive therapy to be associated with significant, but manageable toxi...New therapy may give options to those with neuroendocrine tumors
... Today, only 18 percent of patients diagnosed with metastatic neuroendocrine cancer survive for five years after diagnosis, and complete cure is impossible. Doctors diagnose about 2,500 of the tumors in the nation a year, according to the latest estimates by the American Cancer Society. USC/Norris Comprehensive...Study shows Erbitux may fight colorectal cancer after other therapies fail
...d the phase II trial of cetuximab to patients with metastatic colorectal cancer who had already tried and failed treatment with fluoropyrimidine drugs (such as 5-FU) and the drugs irinotecan and oxaliplatin. Some patients had undergone as many as nine prior courses of chemotherapy. In all, 346 patients particip...Jefferson researcher's results show promise for metastatic eye melanoma
...ads one of the few programs in the nation treating metastatic uveal melanoma, which is a melanoma originating in...as already opened for patients with uveal melanoma metastatic to the liver. The phase 2 trial compares immunoembolization to embolization, or cutting off the tumo...Breast cancer chemotherapy regimen associated with life-threatening complications
...perior to some single classes alone in advanced or metastatic breast cancer, according to background information...at the time of our trial) in both the adjuvant and metastatic settings. At this time the doxorubicin-docetaxel regimen should not be recommended outside of carefu...Patients with suspicious axillary breast lymph nodes should undergo fine-needle aspiration
... aspiration, those patients whose results turn out metastatic can forego sentinel lymph node biopsy for axillary...09 of the suspicious lymph nodes were confirmed as metastatic upon surgical dissection. "With ultrasound-guided fine-needle aspiration, patients can receive a m...Disease progression model of pancreatic cancer developed by Penn researchers
...ltiple levels. "In terms of clinical presentation, metastatic burden, and histological changes in tissue, this m...ts are required to create and support invasive and metastatic disease, we hope to translate our findings into better therapies," states Hingorani. The study was...Cancer killing virus shows early promise against colorectal cancer
... excellent approach for delivering active drugs in metastatic colorectal cancer with liver metastases. "The application of the tumoricidal virus by the arterial route could be of high interest since higher viral load will be delivered to the liver metastases," he said. "These results represent the first time t...Chemotherapy options improve for patients with advanced colorectal cancer
...oxaliplatin (FUFOX) in the first-line treatment of metastatic colorectal carcinoma (MCRC). The findings are repo...reatment in first-line treatment for patients with metastatic colorectal carcinoma." Commenting on the study, Professor Hans Joachim Schmoll of Martin-Luther-Univ...