Fluctuating eye pressure associated with visual field deterioration in glaucoma patients
...cell damage in glaucoma, but no single cellular or molecular cause satisfactorily explains the condition in all patients, Dr. Caprioli writes. Long-term variability may disrupt homeostatic mechanisms. Irregular and large IOP fluctuations may cause a loading and unloading of stresses, and as opposed to conditio...1 of 2 pediatric kidney disease research centers in world established
...nic at Childrens Hospital of Wisconsin. The basic molecular and cellular mechanisms of the majority of pediatr...ers. Basic research at the laboratory bench at the molecular and cellular level can unveil discoveries that can lead to clinical improvement at the patient's bed...New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
... play a role in breast cancer pathways. Through molecular profiling of the downstream effects of the spliced XBP1, Dr. Clarke and his colleagues discovered that expression of several anti-apoptotic genes responsible for programmed cell death including BCL2 are altered. While they have not yet determined t...Penn study finds pro-death proteins required to regulate healthy immune function
... and Professor of Cancer Biology and Medicine. The molecular basis of both findings is based on how Bax and Bak work on intracellular membranes. Specifically, the team found that when the T-cell receptor was stimulated on mutant cells lacking both proteins, proliferation was severely reduced relative to norm...Chromatin remodeling complex connected to DNA damage control
HOUSTON - When molecular disaster strikes, causing structural damage to DNA, players in two important pathways talk to each other to help contain the wreckage, scientists at The University of Texas M. D. Anderson Cancer Center report in the August edition of Cell. This con...Pathway links inflammation, angiogenesis and breast cancer
...ty that this TNFa-driven activation of mTOR is the molecular link between obesity and heightened cancer risk. Obese mammals have high levels of TNFa secreted by their fat cells. For Hung, the Cell paper is part of an ongoing effort to define the cancer-inducing activity of IKK and its sibling, IKKa. He has f...Reductive stress linked to heart disease
...uthor. The protein alpha B-Crystallin, termed a molecular chaperone, normally helps long strips of other proteins fold inside cells. When it works properly, the cell produces the correct amount of reduced glutathione, which is healthy for the body. Unfortunately, when the gene that makes alpha B-Crystallin ...Indiana University Imaging Center receives $6M grant for kidney research
...iate professor of medicine and of biochemistry and molecular biology; the Three Dimensional Quantitative Imaging Core, directed by Carrie Phillips, M.D., associate professor of medicine and of pathology, and the Intravital Imaging Core, directed by Dr. Molitoris. With the renewed grant center researchers hav...Statin drugs may delay progressive artery damage in children
...admitted if they had one parent with a clinical or molecular diagnosis of FH and met other criteria, including elevated LDL. The children were randomized to receive the drug pravastatin or placebo for two years. Those younger than 14 received 20 milligrams (mg) of the statin daily, and those 14 or older rece...Method shows promise for early detection of pancreatic cancer
..., a different organ than the pancreas -- will have molecular and other kinds of abnormal changes. No one can detect these changes earlier than we can. To test the effectiveness of the technology in screening for pancreatic cancer, Backman and Liu have been collaborating with Randall E. Brand, M.D., a gastroe...Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
... second leading cause of cancer mortality, and the molecular pathways [by which it develops] remain incompletely understood, said Dong, a McKnight Presidential Professor in cancer prevention and director of the universitys Hormel Institute in Austin, Minn. In this study, we provided evidence showing that TOPK ...W.M. Keck Foundation announces 2007 class of Distinguished Young Scholars in medical research
...three-dimensional Rosetta cell structures combines molecular genetics, live imaging, and quantitative statistical analysis. Her study of a fruit flys cell structure may be applied to other organisms cell structures, with the potential to develop approaches to analyze cell behavior and structure in living embry...Takeda responds to the FDA advisory committee recommendation
...e different clinical effects due to differences in molecular structure, said Dr. Khan. ACTOS is an effective and appropriate treatment option for people with type 2 diabetes. Since the introduction of ACTOS in August 1999, almost 70 million prescriptions have been written, covering more than 8 million patient...New algorithm matches any tumor cells to best possible anti-cancer treatments
... Thus, an algorithm that could help rapidly sort molecular information about a patients particular tumor and ...xamines both cancer cells and drug activity at the molecular level, these newly discovered drugs should be effective in patients. This pre-screening for effectiv...UCLA, Italian chemists move closer to solving Lou Gehrig's disease mystery
...ast, a model organism, using the then new tools of molecular biology to redesign the protein and make new mutant forms of the protein that would have different inorganic properties, she said. We were making mutant forms of this enzyme to study, but with no connection to disease. I remember the day in March 1...Taking animals out of laboratory research
... and tissue cultures, computer modelling, cell and molecular biology, epidemiology and other methods, they will one day be able to completely remove animals from medical research while still maintaining crucial work to defeat diseases that affect millions of people. The new FRAME Alternatives Laboratory, wi...University research wins royal accolade
...analysis, medicinal chemistry, structural biology, molecular and cellular sciences, drug delivery and tissue engineering. It is also a centre of excellence in social research in medicines and health. The school was singled out for enhancing significantly the development of new medicines. Sir Andrew will pr...Damon Runyon renews its $2.25 million investment to support young clinical cancer investigators
...terferon therapy in ATLL and identify the specific molecular markers associated with response and prognosis. Ultimately, his studies will provide a framework to develop tests that distinguish patients who will benefit from interferon therapy from those who are unlikely to respond. Dr. Joel Rubenstein br...Fluorescence diffuse optical tomography provides high contrast, 3-D look at breast cancer
...ing FDOT, the intravenous addition of an exogenous molecular agent, ICG, was used to enhance tumor contrast. T...sents a critical first step towards application of molecular imaging probes such as dyes and molecular beacons that bind to tumor-specific receptors in deep tiss...Weill Cornell Medical College announces gifts totaling $400M
...health and infectious diseases; children's health; molecular therapeutics; and reproductive and regenerative medicine. The goal is to translate the benefits of research advances immediately to patients, supporting Weill Cornell's mission to provide the highest standards of patient care through less invasive p...