Tag: "molecular" at medical news
Cincinnati Children's researchers publish findings on potential target for leukemia treatment
...inue to make important progress in deciphering the molecular
processes involved in the development and maintenance of the immune and blood system and how disruption of key proteins may contribute to leukemia," said David A Williams, M.D., Director of Experimental Hematology, Cincinnati Children's. "Through a ...
Scientists find 'chemo brain' no figment of the imagination
...of neuronuclear imaging and associate professor of molecular
and medical pharmacology at the David Geffen School of Medicine at UCLA. "Our study demonstrates for the first time that patients suffering from these cognitive symptoms have specific alterations in brain metabolism." Silverman and his colleagues us...
Blood cells linked to heart attacks, other inflammatory diseases
...n are responsible as well for starting a series of molecular
events that results in overproduction of Cox-2, an...between blood platelets and monocytes to a pair of molecular
control switches that turn Cox-2 production on and off. "It's a mechanism for precise control of Cox...
USC researchers discover breast cancer stem cells in bone marrow
...ime risk for relapse. We definitely need to pursue molecular
studies of these putative stem cells."...
Researchers seek to design first treatment for neuroAIDS
...gy at the Medical Center, recognized that a second molecular
target, an enzyme called mixed lineage kinase 3 (MLK3) may be "of equal or greater importance" than GSK-3b. HIV exposure throws off the ability of MLK3 to regulate enzymes that maintain the balance between cell survival and cell death, shifting it to...
Three molecular triggers threaten leukemia patients
...m of adult leukemia will require blocking multiple molecular
pathways that fuel the disease, researchers at The...nsplantation. Patients who had none of the three molecular
cascades active had a median survival time of 78.6 weeks. For those with one highly active pathway, ...
Study unveils how West Nile virus evades immune defenses, points to vaccine development
... binds to IFNAR, subsequently signals the JAK-STAT molecular
pathway, a series of biochemical reactions essential for turning on immune-defense genes, allowing the body to clear out the virus. This process occurs normally in the African strain. Infection by the Texas strain, however, blocked IFNAR signaling ac...
Optics tests for early Alzheimer's diagnosis make significant advances
...e obtained in mice that the tests can detect early molecular
signs of the disease in the eye even before Alzheimer's pathology is present in the brain. This achievement raises hopes for detecting the disease at its earliest stages and slowing the progression of the disease to a crawl. Goldstein envisions t...
Scientists stop colon cancer growth in mice by blocking just one enzyme
...uctase activity and checked the responses of known molecular
links in the chain of colon cancer cell growth. "In a nutshell, when we inhibited aldose reductase by using pharmacological inhibitors or genetic manipulations, all the inflammatory players were significantly blocked," Srivastava said. "We really u...
Impaired gene helps non-small cell lung cancer resist drug
...tive to cisplatin," Ji says. The team packaged a molecular
NPRL2-producing machine called a plasmid expression vector in a nanoparticle ? a fatty sphere so small it's measured in billionths of a meter. The nanoparticles are injected into the mice, find their way to tumor cells, bind to them, and the NPRL2- p...
Serotonin receptor: A rheostat in brain for emotion that may be linked to depression
...ervation could be important in understanding a key molecular
pathway that may make some people more vulnerable ...tations to be drawn about the relationship between molecular
changes in the brain and differences in behavior. In earlier studies, Dr. Hariri and colleagues es...
Science of Learning Center comes to UC San Diego
...ning, psychology, cognitive science, neuroscience, molecular
genetics, biophysics, mathematics, and education. "Creating a Science of Learning Center with our colleagues from Rutgers and from Vanderbilt is really an exciting development that is consistent with the mission and vision for this campus. We have...
ABCB6 is key to production of heme in hemoglobin
...ll be better able to study certain diseases at the molecular
level and learn more about their causes and perhaps how to prevent or treat them. One such group of diseases is cutaneous porphyria, a buildup of porphyrins that causes the skin to blister and swell in sunlight; and acute porphoryia, a nerve problem ...
University of Virginia health system wins $5.5 million grant to help detect atherosclerosis
...r. Klaus Ley, professor of biomedical engineering, molecular
physiology and biological physics and director of the Robert M. Berne Cardiovascular Research Center at UVa. "Currently, there is no reliable method to detect vulnerable plaque. But we do know the properties of the molecules that are found on the sur...
Estate of fashion designer Geoffrey Beene donates funds to Memorial Sloan-Kettering Cancer Center
...n Memorial Hospital, pursues new insights into the molecular
mechanisms of cancer from the perspective of clinical oncology. "The world knew Geoffrey Beene as a person of singular ability and accomplishment, and the Geoffrey Beene Cancer Research Center will embody his remarkable commitment," said Douglas ...
Major cancer study aims to identify protein markers for early-stage disease
...a technique used to detect and measure the precise molecular
weight of proteins. A critical second step will involve consolidating the data and analyzing it, with the goal of piecing together the fragments of proteins identified in the research into recognizable molecules, and identifying patterns of proteins...
New path from estrogen to survival in breast cancer cells described
...ancer Center are now able to explain, in exquisite molecular
detail, how the estrogen hormone can help keep bre...val, and in the process, have identified potential molecular
drug targets. "It's a very complex story, but we have been able to bring together a number of basi...
Jefferson scientists find boosting protein levels staves off heart failure
...nstrated a newly discovered link between a certain molecular
signaling pathway and changes in S100A1 levels in the heart after heart attack. Certain cell receptors called Gq-coupled receptors, which include alpha-adrenergic and angiotensin receptors, play a role in cardiac hypertrophy and "have been implica...
The Starr Foundation launches multi-institutional cancer consortium
...logy platforms designed to unravel the genetic and molecular
basis of cancers Application of these technolog... research to provide insights into the fundamental molecular
and cellular processes underlying cancer Activities selected for funding through the Starr Cancer ...
Cardiologist's 'living chip' changes science of disease monitoring
... chip's ability to detect changes. The company's molecular
biology team is being led by Bradford Berk, M.D, P...d. The company utilizes experts in the fields of molecular
biology, clinical cardiology and electrical engineering, and brings together scientists, engineers, ...
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