Bacteria get off easy in sinus infections
...inflammation, and for this we need research at the molecular level to find a solution."...Newly discovered behavior in cancer cells signals dangerous metastasis
..., Mariano Garcia-Blanco, M.D., Ph.D., professor of molecular genetics and microbiology. The researchers will publish their findings in the Sept. 19, 2006, issue of the journal Proceedings of the National Academy of Sciences, now available on line. The research was funded by the National Cancer Institute. Unt...New drug target might sidestep gleevec resistance, Jefferson scientists show
...as Jefferson University, transcription factors are molecular switches that turn on genes when their function is needed. C/EBP-alpha expression is low in leukemia cells such as those with the BCR-ABL protein defect, which causes chronic myeloid leukemia (CML), a disease that Gleevec treats so well. Gleevec i...M. D. Anderson, BCM, launch research effort targeting asthma and allergic diseases
A new research alliance focuses on a molecular master switch suspected of igniting the inflammato...ed cells known as mast cells. TSLP then launches a molecular cascade that results in overproduction of the immune system T cell known as Th2, a known culprit in ...Molecule helps cells plug leaks following lung injury
...e late Robert Costa, professor of biochemistry and molecular genetics at UIC, whose research focused on FoxM1, the researchers developed a mouse model that lacked the FoxM1 gene only in endothelial cells. In the study, lung injury was induced in normal mice and in the gene-deleted mice. Blood vessels in the ...Test can predict spread of eye cancer to liver
...ere it quickly turns deadly. They also believe the molecular screening test may one day help determine the prog...iences and associate professor of cell biology and molecular oncology, reported on the screening test today at the American Academy of Cancer Research meeting in...UC Davis researchers find added benefit of statins in those at high risk for heart disease, diabetes
...tant discoveries about the way statins work at the molecular level. Compared to the placebo group, monocytes from patients exposed to statin produced less interleukin-6 and TNF, two critical molecules in insulin resistance and the development of cardiovascular disease. In addition, the researchers made the nov...An advanced genetic diagnostic method for multiple myeloma
...t these procedures will promote the description of molecular targets for future, more effective treatments of MM. These new techniques for genetic diagnosis of MM are already being applied in 20 hospitals in Spain. And in a not too distant future, these tests will permit us to offer each patient a treatment a...Mayo researchers discover HIV dependence on a human protein
...c protein -- LEDGF/p75 (p75). This protein forms a molecular tether between chromosomes and HIV's integrating p...tethers" HIV integrase to human chromosomes like a molecular rope and also protects it from the cell's protein-degrading machinery. While these were provocative ...Carnegie Mellon receives NIMH/NSF grant to examine mechanisms that underlie neuronal synchronization
...dation (NSF) program to elucidate how cellular and molecular changes in neurons lead to their synchronized firing. Ultimately, this work is critical to understanding brain disorders, such as schizophrenia, which are thought to involve disruption of neuronal synchronization. The research is part of a project Ur...Case and Cleveland Clinic researchers identify molecule in age-related macular degeneration
...f lipid oxidation, and generated some of the first molecular tools that have been used in clinical studies relating the hardening of the arteries in heart disease. In the hope of preventing the formation of toxic molecules in the eye, through the combination of oxygen with lipids, Salomon is now studying the p...Proteins necessary for brain development found to be critical for long-term memory
...ces. "This study presents strong evidence that a molecular process fundamental during development is retained...ogy and Behavior. "It is a striking example of how molecular rules employed in building a brain are often reused for different purposes throughout a lifetime." ...Depressed patients experience excessive inflammation during stressful situations
.... The goal is to find potential targets within the molecular machinery of the immune system so we can better treat major depression and minimize its consequences on health." ...Muscle cells self-destruct rather than grow with use
...t regenerate, says Dr. Shinichi Takayama, cell and molecular biologist at the Medical College of Georgia. The finding illustrates BAG3's importance in maintaining mature skeletal muscle, researchers say in the September issue of the American Journal of Pathology. They hope it will lead to prevention of mus...Obesity leads to more aggressive ovarian cancer, Cedars-Sinai research shows
... also appeared to be different. "While further molecular studies are warranted, our study suggests that fat tissue excretes a hormone or protein that causes ovarian cancer cells to grow more aggressively," said Li, who is also a physician in the Department of Obstetrics and Gynecology at Cedars-Sinai Medic...Penn researchers to get 7 Tesla whole-body MRI system
... Imaging these nuclei may provide disease-specific molecular and functional information unobtainable on convent...tudy of neurodegenerative and metabolic disorders, molecular imaging for cancer detection and treatment monitoring, novel approaches to cardiovascular disease an...Speedsters' traffic fines fund new research on spinal cord injury
...nerve cells. He and Giger will explore the complex molecular environment around the site of a spinal cord injury in an effort to find out what stops those cells from fixing damaged nerves in the spine. In addition to his own research, Noble helps to manage spinal cord research throughout the state through hi...Nanowire arrays can detect signals along individual neurons
...n that nanowires can detect, with great precision, molecular markers indicating the presence of cancer in the body, as well as single viruses. Their latest work takes advantage of the size similarities between ultra-fine silicon nanowires and the axons and dendrites projecting from nerve cells: Nanowires, like...Columbia researchers restore memory lost in mice with Alzheimer's
...ers discovered that the enzyme Uch-L1 is part of a molecular network that controls a memory molecule called CREB, which is inhibited by amyloid beta proteins in people with Alzheimer's. By increasing Uch-L1 levels in mice that had Alzheimer's, they were able to improve the animals' ability to create new memori......easily. "This study shows that both clinical and molecular analyses can distinguish patients with Loeys-Dietz syndrome from those with either Marfan syndrome or vascular Ehlers-Danlos syndrome," says Harry Dietz, M.D., director of the William S. Smilow Center for Marfan Syndrome Research at Johns Hopkins, pr...