Angiogenesis factor may help tumors prepare the way for spread to lymph nodes
...lymphatic vessels were shown to carry the receptor molecule known to interact with VEGF-A. Examination of sentinel lymph nodes those most adjacent to the tumors showed increased spread of malignant cells to the nodes of transgenic mice. Those cells expressed the green fluorescent protein, confirming they ...Liver may be source of 'good' cholesterol
...reatments to raise levels of this heart-protecting molecule in humans. In the May issue of the Journal of Clinical Investigation, researchers from Wake Forest University School of Medicine and colleagues will report on a project that used gene-targeting in mice to simulate a rare disease in people Tangier d...Breakthrough in national diseases
...titled "MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction" will be published on the Nature Genetics website on Sunday 10 April at 1.00 p.m. (Eastern US Time)....Late-breaking science presented at 57th AAN Annual Meeting
...by the mutation--the ability to bind a high-energy molecule called CTP--is also impaired by other CMT gene mutations, suggesting this may be a central pathway for a large class of peripheral neuropathies. New Parkinson's Disease Gene Mutation is Very Common in North Africa The newest gene for Parkinson's di...Stanford gut check shows diversity of intestinal ecosystem
... technique that compares the genetic sequence of a molecule shared by bacteria and archaea. The molecule, 16S rRNA, plays a role in the translation of the genetic code and thus is critical to the organisms. However, small variations in the 16S rRNA gene sequences allow scientists to detect distinct bacteria. ......archers could follow a single topoisomerase-enzyme molecule over time as it acted on a single DNA molecule. The topoisomerase clamps onto the DNA, cuts through one of the two DNA strands, and then lets the DNA unwind before sticking the broken ends back together again. With the help of sensitive measuring dev...Variant in gene associated with telomeres predicts longer survival of deadly brain tumor
...r LL variant genotype to produce an antisense-like molecule that suppresses the expression of human telomerase, he says, and this modulation may enhance the effect of the chemotherapy and radiation treatment on the patients with the SS variant genotype. Bondy says the association between the SS variant genoty...Lessons to be learnt from life at the very limit
... lethal hypoxic environment is it possible? For a molecule upon which all human life depends our understanding of oxygen and its physiological role is far from complete. This conference will explore extreme physiology and critical care, covering the history and future of extreme high altitude research. Expe...Fatal brain disease holds clues to dementia
...'s disease. "We have demonstrated the linkage from molecule to cell to learning and memory, and can relate this to a particular area of the brain," Dr Hannan said. "Our work shows that the defective huntingtin gene disrupts how large groups of neurons 'talk' to one another and adjust their wiring in response ...American Academy of Neurology sums up scientific highlights from 57th annual meeting
...ls destroy the insulating myelin around neurons, a molecule called 7-ketocholesterol is released. This molecule may stimulate other immune cells to attack the neuron. Understanding this important step may help de...New insights into HIV immunity suggest alternative approach to vaccines
...es of human molecules, most prominently with a fat molecule called cardiolipin. "It appears the most vulnerable spots on the outer coat protein of HIV, to which the most protective antibodies bind, are the target of autoantibodies that also react with normal human tissues and are normally destroyed by the imm...Eliminating enzyme dramatically reduces cardiovascular disease
... confirmed these results in normal mice by using a molecule that blocks the effects of ACAT2. This study, reported for the first time today, will be followed by a pilot study in monkeys. Rudel hopes the research will lead to a drug that can inhibit the enzyme's production in humans. Scientists already know th...Excess oxygen worsens lung inflammation in mice
...tkovsky and colleagues into the role played by the molecule adenosine in regulating inflammation. Inflammatory chemicals produced by the immune system in response to infection or injury must eventually be switched off so that excessive tissue damage can be avoided. Dr. Sitkovsky and his colleagues have shown ...Molecular change occurring during brain tumor progression also evident in breast cancer
...behavior, proliferation and migration. The laminin molecule is composed of three chains -- designated alpha (), beta (]) and gamma (^) -- that are linked together in various combinations to form 15 known isoforms or types of laminin. Each isoform has distinct characteristics and functions. Isoforms are kn...Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
...les. When put into cell culture, a recombinant DNA molecule multiplies itself to form a colony of daughter cells that secretes the desired protein. These cells become "factories" for the production of the protein coded for by the inserted DNA. As it turned out, this was the case as well for the transferrin/G-...New research raises questions about buckyballs and the environment
...tific society. A buckyball is a soccer ball-shaped molecule made up of 60 carbon atoms. Also known as fullerenes, buckyballs have recently been touted for their potential applications in everything from drug delivery to energy transmission. Yet even as industrial-scale production of buckyballs approaches real...Penn study shows liver receptor key to diet-dependent differences in blood lipid levels
...sylvania School of Medicine have discovered that a molecule found in liver cells is an important link in explaining the relationship among diet, lipid levels in blood, and atherosclerosis. The research team surmises that drugs targeted at the liver may one day help lower elevated lipids and battle cardiovascu...New class of drugs may treat lung tumors resistant to Iressa and Tarceva
...und that a particular set of mutations in the EGFR molecule could identify patients whose tumors would respond...secondary mutation in a different part of the EGFR molecule found in some but not all resistant patients. These secondary mutations are similar to mutations ass...Researchers develop new concept for single molecule transistor
...ave designed and tested a new concept for a single molecule transistor. They have shown, for the first time, t...ged, while all surrounding atoms remain neutral. A molecule placed adjacent to that charged site is tuned, which allows electrical current to flow through the m...Hebrew University researcher develops compounds to control bacteria
...ity of the bacteria in the biofilms. A boron-based molecule that is produced by these bacteria, called auto inducer-2, controls the signals in this quorum sensing process. Jabbour has succeeded in synthesizing modified chemical compounds, resembling the structure of the natural auto inducer-2, that can disru...