Clarifying controversy in multiple sclerosis
... in which the protective nerve cell coating called myelin is damaged. Although uncontrolled CNS inflammatio...inflammatory response may actually restore damaged myelin and nerve function. Now, in a study appearing online on March 23 in advance of print publication in...Stem cell treatment succeeds in spinal cord-injured rats
...is. Fehlings showed that where stem cells restored myelin in the injured spine, rats showed some recovery and walked with more coordination. One new aspect demonstrated by the study is that "the maximal effect of transplanting these cells is early after injury," says New York University School of Medicine p...Stem cells found in adult skin can be transplanted and function in mouse models of disease
...he central nervous systems of mice that don't have myelin in their brains. While the research occurred in mouse models, some of their data indicate that human SKPs can do the same thing. "Previous work has only dealt with SKPs in culture and their more basic biology. Now we have shown that SKPs can make at ...Hopkins scientists use embryonic stem cells, new cues to awaken latent motor nerve repair
...otor neurons. Like the coating on electrical wire, myelin prevents weakening of the traveling electrical imp...ng impulses several feet. Once laid down, however, myelin inhibits further nerve growth -- nature's way to discourage excessive wiring in the nervous system. ...Refined stem cell therapy helps paralyzed rats recover
...erapy that combines differentiated stem cells with myelin inhibitors and a motor axon tropic factor helped p...o potentially neutralize the inhibitory effects of myelin on axon outgrowth. And some groups received a motor axon tropic factor, GDNF, to potentially attract...Speedsters' traffic fines fund new research on spinal cord injury
...es sustain other damage, including the loss of the myelin covering that enables the nerves to send crisp ele...ialized cells called oligodendrocytes that provide myelin for nerve cells. He and Giger will explore the complex molecular environment around the site of a sp...Can a vitamin alleviate chronic, progressive multiple sclerosis?
...ged through inflammation, loss of their insulating myelin coating, and degeneration. This damage disrupts ne...treatments mainly protect against inflammation and myelin loss, but do not completely prevent long-term axon damage. A team led by Shinjiro Kaneko, MD, a re...Natural, soy-based substance might help fight MS, Jefferson neuroscientists find
...cting the central nervous system (CNS). In MS, the myelin coating of nerve fibers becomes inflamed and scarred. As a result, messages cannot be sent through the nervous system. Dr. Rostami, who is also director of the Neuroimmunology Laboratory in the Department of Neurology at Jefferson Medical College,...U of MN doctors uncover treatment for advanced ALD patients
...nsplantation. ALD is a progressive degenerative myelin disorder that affects young boys. Myelin is the i...wed a decrease in inflammation and preservation of myelin after administering NAC. We believe that NAC can also help patients with less advanced cases of ALD...Inhibiting blood to save the brain
.... Past studies showed that the destruction of the myelin sheath is associated with the accumulation of fibr...evented further microglia activation and damage to myelin in the diseased mice, allowing them to survive with improved motor function. "Importantly, this ap...Researchers discover gene crucial for nerve cell insulation
...ry has implications for understanding disorders of myelin production. These disorders can affect the periph..., which causes progressive muscle weakening. The myelin sheath that surrounds a nerve cell is analogous to the insulating material that coats an electrical ...Breakdown of myelin implicated in Alzheimer's, UCLA research shows
...he age of about 50, but in these later stages, the myelin becomes more and more susceptible to damage. Now, ...ggests that it is the breakdown of this late-stage myelin that promotes the buildup of toxic amyloid-beta fibrils that eventually deposit in the brain and bec...Glucosamine-like supplement inhibits multiple sclerosis, type 1 diabetes
...attack specific tissues in the body, such as brain myelin in MS and insulin-producing cells of the pancreas in diabetes. Study results appear on the online version of the Journal of Biological Chemistry. This finding shows the potential of using a dietary supplement to help treat autoimmune diseases, sai...'Cars' imaging reveals clues to myelin damage
...insulates nerve fibers. Learning exactly how the myelin sheath is degraded might enable scientists to dete...Stokes Raman scattering, or CARS, to study how the myelin sheath is degraded by a molecule called lysophosphatidylcholine, known as LPC. The LPC does not caus...DNA vaccine against multiple sclerosis appears safe, potentially beneficial
...iple sclerosis (MS), the immune system attacks the myelin sheaths that protect nerve cells in the brain and ... attack specific substances in the myelin, such as myelin basic protein. Certain cytokines, small proteins produced by cells that trigger inflammation, also m...