High risk of second cancers in survivors of childhood soft tissue sarcomas
...ous studies have reported increased risks of acute myelogenous leukemia following treatment of children with soft tissue sarcoma, particularly in those receiving chemotherapy for rhabdomyosarcoma. In addition, both clinical and registry-based surveys have reported that these children have an increased risk of s...UT Southwestern researchers show new drug may help treat certain forms of leukemia
...e with a form of leukemia similar to human chronic myelogenous leukemia (CML), which is diagnosed in about 5,000 people in the United States each year. Patients with CML produce a mutated enzyme that stimulates white blood cells to overproduce, causing leukemia. The Blood study shows that PD166326 is nearly 100 ...Cancer drug slows poxvirus in mice
...Abl, causes a rare form of cancer known as chronic myelogenous leukemia (CML). Gleevec inhibits Abl-family tyrosine kinases and has proved very useful in treating CML. To learn whether Gleevec could prevent or lessen vaccinia's ability to spread in a living organism, the researchers treated mice with either sali...Largest study of unrelated bone marrow transplantation for leukemia serves as benchmark
...e recurrence specifically in patients with chronic myelogenous leukemia, eliminated the potential benefit of reduced GVHD," ," said John E. Wagner, M.D., professor of pediatrics and scientific director of clinical research, Blood and Marrow Transplantation Program and Stem Cell Institute, and lead author of the ...Hopkins geneticist discovers mutations in cancer cells that suggest new forms of treatment
...tal, breast and ovarian cancer, as well as chronic myelogenous leukemia, gastrointestinal stromal tumors and lymphoma. Riggins and colleagues analyzed a catalog of 518 protein kinase sequences taken from the Human Genome Project. Using high-throughput gene sequencing equipment based at the Venter Institute's Joi...Backyard treatment may yield leukemia treatment
...tified a new pathway in the progression of chronic myelogenous leukemia (CML). They also discovered that an extract from the root of a common ornamental plant can suppress the process. The findings, appearing in the November issue of Cancer Cell, may yield new treatment options for the estimated 4,600 people in...St. Jude unlocks mystery of very aggressive leukemia
...inib is already successfully used to treat chronic myelogenous leukemia (CML), another blood cell cancer caused by the Bcr-Abl mutation. The St. Jude study provided evidence that imatinib resistance in mouse models of ALL did not depend strictly on the presence of Bcr-Abl and the loss of Arf genes in the cancer...M. D. Anderson: Setting the benchmark in brain tumor treatment
... which has revolutionized the treatment of chronic myelogenous leukemia, was first tested in brain tumors to little effect. Gilbert predicts that years will pass before testing of combined agents is routine. Drug testing guidelines are not yet flexible enough to allow clinicians to test approved agents w...OHSU Cancer Institute study points to future of personalized medicine
...rks. Initially used to treat patients with chronic myelogenous leukemia, it has also proved successful in treating a rare stomach cancer called gastrointestinal stromal tumor (GIST). But imatinib doesn't work for every GIST patient, and even when it does work, many GIST patients develop resistance to it. Like...Vitamin D targets thrombosis in cancer patients
...ced stages of prostate cancer, in vitro studies of myelogenous leukemia cells, monocytes and osteoblasts and observation in mice hold promise for improved safety in a wide range of cancers. "This is a serendipitous outcome," says Dr. Venner. "It wasn't what we were looking for, but it offers an avenue of investi...Longest ever follow-up study of a targeted cancer therapy shows excellent results
...- The overall survival of most people with chronic myelogenous leukemia (CML) treated with imatinib (Gleevec, STI-571) is extremely high and the relapse rate is quite low, according to new data from a study out of the Oregon Health & Science University Cancer Institute. The overall survival at five years is 89 p...Five-year study confirms Gleevec's long-term benefits
...Novartis, as a treatment for patients with chronic myelogenous leukemia. In addition to GIST, it is also being studied as a potential therapy for certain types of blood and skin cancers....Drug attacks prostate cancer in mouse model by destroying its blood supply
...rmaceuticals Corporation, is used to treat chronic myelogenous leukemia and gastrointestinal stromal tumors. Cancer cells are biologically diverse and genetically unstable, Fidler says, so it is highly unlikely that a single therapy will prevail, necessitating a multi-modal attack on the disease....Jefferson scientists show 'miracle' cancer drug Gleevec can be toxic to the heart
...of the study, prompted by 10 patients with chronic myelogenous leukemia (CML) who developed severe congestive heart failure while taking Gleevec, appear July 23, 2006, in an advanced online edition of the journal Nature Medicine. "We found that the molecular target of the drug, the Abelson tyrosine kinase (ABL...New hope in cancer vaccines emerges as novel therapies are developed and tested
...kinds of leukemia of myeloid origin, such as acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), and pre-leukemic myelodysplastic syndromes. A vaccine can even be useful in patien...Cancer drug may be remedy for rheumatoid arthritis, Stanford study finds
...evec targets kinase gene mutations seen in chronic myelogenous leukemia or CML (a bone marrow cancer) as well as certain types of stomach cancers. The same kinases turn out to play a critical role in rheumatoid arthritis. Robinson said that the field of autoimmune disease research has been trying to develop ki...Three molecular triggers threaten leukemia patients
...d and bone marrow samples of 188 adults with acute myelogenous leukemia (AML) and then followed the patients' pro...s been development of targeted therapy for chronic myelogenous leukemia (CML). The drug Gleevec and its successors inhibit one aberrant protein, increasing the med...'Tribbles' protein implicated in common and aggressive form of leukemia
...ave identified a new protein associated with acute myelogenous leukemia (AML). Several lines of evidence point to a protein called Tribbles, named after the furry creatures that took over the starship Enterprise in the original Star Trek series. Tribbles was first described in fruit flies. "Tribbles had never...Five-year study by OHSU Cancer Institute shows Gleevec's excellent survival rate
...he overall survival rate for patients with chronic myelogenous leukemia (CML) taking this new experimental drug was unknown. "We've completely changed the outlook for patients with this disease. Before Gleevec, patients were fortunate if they lived five years. Now, we've given patients a hopeful future," said ...Dasatinib shows high early response rate as first treatment for chronic myelogenous leukemia
...CAGO - An established second-line drug for chronic myelogenous leukemia has high response rates when given to newly diagnosed patients as their first therapy for the disease, according to early results from a Phase II clinical trial at The University of Texas M. D. Anderson Cancer Center. "Patients taking dasa...