Nanoparticles offer new hope for detection and treatment
...., professor of medicine, are co-inventors of this nanoparticle technology. The effectiveness of the nanoparticles...hat make it especially interesting as a target for nanoparticle therapy. Melanoma has a horizontal phase, when it spreads across the skin surface, and a vertical ph...Nanoparticles carry cancer-killing drugs into tumor cells
...n horse," Baker explains. "Folate molecules on the nanoparticle bind to receptors on tumor cell membranes and the ...ys, 30 percent to 40 percent of the mice given the nanoparticle with methotrexate survived," says Jolanta Kukowska-Latallo, Ph.D., a U-M research investigator and f...Rice nanophotonics lab gets $3 million training grant
... of nanophotonics include the use of nanoshells, a nanoparticle invented by Halas at Rice, in cancer diagnostics and therapeutics. NSF's IGERT program was initiated in 1997 to meet the challenges of educating U.S. Ph.D. scientists, engineers, and educators with the interdisciplinary backgrounds, deep knowledge, a...Stealth particles to target tumors
...ention in the body, the researchers engineered the nanoparticle shells to target specific cells by attaching a functionalized polymer to the shell. They designed this tentacle-like projection to target a receptor on a tumor cell, or a specific location in the eye, for example. Once the drug arrives via the bloo...Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
...rson Medical College have shown that a microscopic nanoparticle can help fend off damage to normal tissue from radiation. The nanoparticle, a soccer ball-shaped, hollow, carbon-based structure known as a fullerene, acts like an "oxygen sink," binding to dangerous oxygen radicals produced by radiation. The scien...Viral, gold nanoparticles can assemble themselves to potentially find and treat disease
...ve found a way to mix a 'genetically programmable' nanoparticle with a biologically compatible metal that together target specific locations in the body." For example, these nanoplatforms could potentially locate damaged areas on arteries that have been caused by heart disease, and then deliver stem cells to the...Jefferson researchers discover that nanoparticle shows promise in reducing radiation side effects
...lege in Philadelphia have shown that a microscopic nanoparticle can help fend off damage to normal tissue from radiation. The nanoparticle, a soccer ball-shaped, hollow, carbon-based structure known as a fullerene, acts like an "oxygen sink," binding to dangerous oxygen radicals produced by radiation. The scienti...MIT nanoparticles may help detect, treat tumors
...o "self-assemble" or stick together. The resulting nanoparticle clumps are too big to get back out of the gaps. Further, the clumps have a stronger magnetic signal than do individual nanoparticles, allowing detection by MRI. "We inject nanoparticles that will self-assemble when they are exposed to proteases insi...New contrast agents may be on horizon for better medical imaging
...M&M candy -- functions as a spacer, preventing the nanoparticle from undergoing a chemical reaction when it comes in contact with water. It also keeps the nanoparticles from clumping and behaving erratically. "The M&M analogy is really a great one because it says you can put things on the outside and you can have...Heat therapy for cancer may be key to 'Lance Armstrong Effect'
...urface proteins carried by cancer cells. Once the nanoparticle finds the correct "address" of the cancer cell, it slips through the cell's surface and heats the cell from the inside out after exposure to a magnetic field. The Hopkins scientists believe that, if injected through the bloodstream, magnetic nanopa...Electric jolt triggers release of biomolecules, nanoparticles
...cisco. "You can think of the useful biomolecule or nanoparticle as a balloon tethered to a surface," he said. "We use an electrical pulse to cut the tether, and it floats away." This method could be used to control the release of drug molecules; nanoparticles; biopolymers such as peptides, proteins and DNA; and...Impaired gene helps non-small cell lung cancer resist drug
...ng machine called a plasmid expression vector in a nanoparticle ? a fatty sphere so small it's measured in billion... Interestingly, mice treated with the gene therapy nanoparticle alone showed a 40 percent reduction in tumor volume and a significant reduction in number of tumors....U-M researchers use nanoparticles to target brain cancer
... cause damage to healthy tissue. In our study, the nanoparticle becomes a vehicle to deliver the drug directly to ...le rats treated with Photofrin incorporated into a nanoparticle survived an average of 33 days. Forty percent of the rats remained disease-free six months after tre...Policy makers, networking agencies told to get their act together for nanoscience
...oated liposome products. Also a European-developed nanoparticle has been expanded into a marketed drug by an American manufacturer. Nano-Hype Besides the lack of a more collaborative mindset, the tendency of scientists to exaggerate what nanoscience can achieve is also undermining the credibility in the fiel...ACS News Service Weekly PressPac -- January 3, 2007
...cientists in Taiwan are reporting development of a nanoparticle drug delivery system that shows promise as a potential way to administer insulin and perhaps other protein-based drugs by mouth rather than injection or nasal sprays. Hsing-Wen Sung and colleagues at the National Tsing Hua University, the Chinese...Nano world off the radar for most
...or a moratorium on nanotechnology due to potential nanoparticle toxicity. Many anti-nanotechnology activists predict the creation of destructive, uncontrollable life forms from nanotechnology. However, some activists realize the potential good and suggest caution as the best approach to development. Science wr...Scientists create dual-modality microbeads to improve identification of disease biomarkers
... into the solution. You just have to make sure the nanoparticle surface is hydrophobic so that it interacts with the beads," said Sathe. The primary biomedical applications for this new technology will be to detect cancer and neurological diseases by identifying certain molecules present in human blood or urine...Probe to detect spread of breast cancer co-developed by UH scientist
...t cancer surgery, a surgeon will inject a magnetic nanoparticle dye, already approved as an imaging contrast agent by the Food and Drug Administration, into the tumor or into tissues surrounding the tumor. Receiving a $250,000 grant to be used from 2004 to 2006 from the United Kingdom Department of Trade and ...Nanoparticles can track cells deep within living organisms
...eatments using unique signatures from the ingested nanoparticle beacons. In an article that will appear in the June issue of the FASEB Journal, lead author Kathryn C. Partlow, a doctoral student in Wickline's lab, describes using perfluorocarbon nanoparticles to label endothelial progenitor cells taken from hu...Mayo Clinic research in cardiovascular disease presented at Experimental Biology 2007
...o so small that some scientists question whether a nanoparticle can live and, if so, play a viable role in causing disease. A new Mayo Clinic study cites evidence showing the presence of nanoparticles near plaque-filled arteries in animal models. The study suggests that nanoparticles potentially represent a pre...