2005 Potamkin Prize goes to neurologists for research in early detection of Alzheimer's disease
...se Research Center approach incorporates informant observations with patient evaluations and results in the accurate identification of the earliest symptomatic stage of the disease. Current efforts focus on detection of preclinical Alzheimer's, prior to the onset of symptoms, using imaging modalities and assays o...New prostate cancer studies look at hormone and protein connection
...oint where androgen is no longer needed. Clinical observations demonstrate clearly that 50 percent of advanced prostate cancers have no PTEN. It is believed that the loss of PTEN removes a crucial protection, which facilitates prostate cancer progression into the androgen-independent stage. Sujata Persad, assist...Specific behaviors seen in infants can predict autism, new research shows
...o rely on parental reports, home videos and direct observations of behavior, using standardized tools like the Checklist for Autism in Toddlers (CHAT). But these tools were designed for children 18 months and older; there has been no instrument to measure autistic behaviors in young infants. So the Canadian rese...Social connections: Could heartwarming be heart-saving?
...-1 and monocyte chemoattractant protein-1. "These observations need further study," Loucks said. Studies indicate that inflammation plays a role in causing atherosclerosis. "It seems to allow white blood cells to tether to and become engulfed in the side of the blood vessel wall," Loucks said. "This allows lip...Scientists report strong evidence of alterations in blood samples of children with autism
...rently accomplished through a series of behavioral observations that are not reliable until a child is between 2 and 3-years-old. "Finding a sensitive and accurate biological marker for autism that can be revealed by a simple blood test would have enormous implications for diagnosing, treating and understanding ...Molecular testing in patients with rare cancer predicts response to Gleevec
...ical Oncology (ASCO). The results confirm previous observations and provide a foundation for molecular testing that can predict who will best respond to treatment with Gleevec. "Increasingly, there will be more drugs like Gleevec that are very specific in their action, and patients' responses to them will be ...As morphine turns 200, drug that blocks its side effects reveals new secrets
...e. "I flatter myself," he wrote in 1816, that "my observations have explained to a considerable extent the constitution of opium, and that I have enriched chemistry with a new acid (meconic) and with a new alkaline base (morphium), a remarkable substance." As he predicted, chemists and physicians soon grew int...Allergies increase risk for corneal transplant rejection, UT Southwestern study shows
...tudy provides insights that might explain clinical observations that patients with eye allergies have a significantly higher risk for rejecting corneal transplants than patients without eye allergies," said Dr. Niederkorn, senior author of the study. "The allergist and ophthalmologist need to work as partners in ...Study examines NSAID use and breast cancer risk
...ncer and particularly nonlocalized cancer. "These observations warrant further exploration because of the public health impact such readily available NSAIDs may have on breast cancer," the authors write. "Additional large-scale prospective epidemiologic studies may help clarify the findings by further examining ...Newly developed treatment for severe grief shown more effective than standard therapy
...elop complicated grief in the United States. Given observations regarding the specificity and clinical significance of complicated grief symptoms, including the lack of response to standard treatments for depression, the researchers developed a targeted complicated grief treatment (CGT). They modified standard in...Prevalence and severity of mental illness in the United States
...al and societal burdens of mental disorders, these observations should lead us to direct a greater part of our thinking about public health interventions to the child and adolescent years and, with appropriately balanced considerations of potential risks and benefits, to focus on early interventions aimed at prev...3D atlas will help navigate the spinal cord
...ons, reproduce these in 3D and make some parallel observations in the human spinal cord (when tissue becomes available), thus supporting both experimental and clinical approaches....Chest x-rays not effective in determining when TB acquired
...-ray) and clinical features, though these clinical observations have been based on studies conducted before the availability of molecular fingerprinting techniques for TB. Molecular (DNA) fingerprinting, also known as restriction fragment length polymorphism (RFLP) analysis is a method for comparing strains of M...Diabetic retinopathy occurs in pre-diabetes
... population before they developed diabetes. These observations may lead diabetes experts to reconsider the diagnostic thresholds used to define diabetes, which are based on levels of blood glucose associated with the development of eye, nerve and kidney complications of diabetes." DPP study chair David Nathan, ...Fish oil does not lower risk of heart problems for patients with implantable defibrillators
... in the June 15 issue of JAMA. Since the original observations that Greenland Eskimos eating a diet high in omega-3 polyunsaturated fats (PUFAs) from sea mammals and fish had an unexpectedly low risk of cardiac death, multiple lines of evidence have suggested that omega-3 PUFAs have antiarrhythmic properties, ac...Avoiding amputation: Early infection intervention can save feet & legs
...e study suggests. "This study grew out of our own observations that many osteomyelitis patients were being treated for months or even years with antibiotics, but not healing, and this can contribute to the loss of their foot or leg," says lead author Peter Henke, M.D., an assistant professor of vascular surgery ...Oral liquid hydroxyurea promising for long-term use in babies with sickle cell anemia
...studys lead author. If a larger trial supports our observations in the HUSOFT Extension, the treatment of sickle cell anemia will undergo a significant change. This study is particularly encouraging because it suggests that we can treat babies with hydroxyurea for several years without side effects serious en...Street-level London air pollution warnings coming via mobile phones
...tegrating other data sources, especially satellite observations and more data on traffic patterns." Regional air quality information is important because not all the pollution affecting a city actually originates there. Depending on the weather, studies show that up to half the air pollution found in some Europ...What don't we know? Science presents the great unsolved scientific mysteries of our time
...sibility of electric-powered railroads, the latest observations of the Pleiades and advice to science teachers on the importance of studying animal brains. Issues over the following decades included articles by Albert Einstein, Edwin Hubble, Louis Leakey and other great scientific thinkers. Over time, the promin...Women report various symptoms after stopping hormone therapy
...a logical clinical strategy arising from these new observations from the WHI." "As has been the experience with prior reports from the WHI, these latest results bring some surprises, some answers to important clinical concerns, and some new questions for future investigation," Dr. Petitti concludes. (JAMA. 2005;...