Clues to the progression of Alzheimer's disease revealed in brain imaging studies
...the current findings in living patients take these observations further," said William E. Klunk, M.D., Ph.D., associate professor of psychiatry at the University of Pittsburgh School of Medicine and co-inventor of PIB, who presented the findings. "If we can delineate the natural history of brain changes in Alzhei...Disruption of gene interaction linked to schizophrenia
... tone in a way that was previously learned. "These observations showed that lack of regulation of glutamate levels due to loss of PRODH function contributed to learning difficulties similar to those found in schizophrenia," Zakharenko said. Moreover, the researchers showed that PRODH deficiency caused a reductio...JCI table of contents: December 1, 2005
...point out, "a major question raised by the present observations is the location of key populations of GLP-1 receptors regulating glucose uptake and insulin secretion." TITLE: Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage AUTHOR CONTACT:...Groundbreaking guidelines promote early detection
...he guidelines include: Recommended questions and observations that can uncover hidden signs of peripheral arterial disease; Clinical clues that a patient may have renal artery stenosis, a narrowing of the arteries that supply blood to the kidney--and a possible cause of poorly controlled high blood pressure or...'Doctor Franklin's Medicine' explores founding father's vast medical legacy
...ose medical theorizing, he turned to data based on observations and careful experiments." A lack of formal medical training was no barrier to practicing medicine in 18th-century America. In fact, only a small percentage of colonial healers had formal medical training and even fewer possessed college degrees. "Wha...Insulin levels and resistance linked to risk of pancreatic cancer
...eported herein require confirmation and along with observations of other studies could potentially have important implications for nutrition and treatment-related cancer preventive strategies that modify or interfere with the insulin resistance pathway to help decrease the burden from this devastating disease. Li...Blood test can accurately diagnose heart failure in patients with kidney dysfunction
...hat of BNP. Our findings thus directly contradict observations based on smaller, less characterized patient populations." Congestive heart failure, which occurs when an impaired heart muscle cannot pump blood efficiently, is a growing health problem and major cause of cardiac death. The diagnosis of heart failu...Toward the future of cancer prevention
...n trials testing them for different cancers. These observations led to the ongoing international Selenium and Vitamin E Cancer Prevention Trial (SELECT) in more than 32,000 patients. M. D. Anderson leaders of SELECT include Lippman and Elise D. Cook, M.D., who led the national effort to recruit minority men, espe...UCLA paper examines how one disease may prevent another
...nts, particularly in regard to HIV/AIDS. "Clinical observations of disease-versus-disease interactions have led to...of several diseases," Stiehm said. "In turn, these observations have led to the development of vaccines, therapeutic antibodies, medications and special diets." De...NYU Child Study Center expert co-authors 'Who Invented Lemonade?'
...ns about everything and everyone; he acts upon his observations rather than passively accepting them. The book follows Billy through his journey to find out who invented lemonade, and at the same time teaches readers how to invent it themselves. Shaw believes that "this book will open people's consciousness to t...Memantine appears effective and safe in moderate to severe Alzheimer's disease
...tudy, cognitive tests, reports from caregivers and observations by clinicians all indicated that memantine was beneficial to AD patients. "The benefits of memantine seen in the double-blind phase were again observed when patients treated with placebo were switched to memantine treatment in the open extension," th...OHSU researchers discover protein fragment that helps predict breast cancer outcome
...sociation for Cancer Research. The study builds on observations the investigators have published over the last five years about the role of the HER-2 oncogene in breast cancer. HER-2, a growth factor receptor, is overexpressed in 20 to 30 percent of breast cancer cases, but it has had limited usefulness in predic...New cocoa evidence on why plant foods are beneficial to cardiovascular health
... in the island dwellers. Linking Dr. Hollenberg's observations to their own findings, Schroeter and colleagues found that the Kuna Indians on the island who regularly consume flavanol-rich cocoa had higher levels of flavanols, as well as higher levels of nitric oxide metabolites in their circulation compared to ...News nuggests: University of Pittsburgh health sciences research roundup
...e orbitofrontal cortex is consistent with clinical observations that stroke and other types of injury to this part of the brain can cause bladder problems. This study suggests that treatment strategies for overactive bladder should target the brain rather than the bladder, adds Dr. Griffiths. Contact: Jocelyn Uh...Study reveals new player in sepsis-associated acute respiratory distress syndrome
...rier lining the blood vessel wall. These and other observations prompted Sukhatme's team to ask whether the Tie-2 signaling pathway is affected in sepsis and, specifically, whether excess Ang-2 levels might promote the leakage of fluid from the blood vessels that underlies ARDS. They tested whether excess level...Palliative radiation actually a cure for some lung cancer patients
...f localized RT. Physicians have long made clinical observations that some patients receiving palliative RT long outlive their estimated survival and a few report even cures. Given that therapeutic doses of RT are much higher, it is not surprising that these reports require evidence-based confirmation. Michael Mac...Japan's ALOS in orbit: ESA will deliver its data to European researchers
...n the Asia-Pacific region, to gather environmental observations in support of sustainable development efforts, to ...AR), a microwave radar instrument that can acquire observations during both day and night and through any weather conditions; the Panchromatic Remote-sensing Instru...Breast ducts: A new site for cancer treatment?
...her tissues unharmed," says Sukumar. Building on observations made by her lab on rat models using drugs that block estrogen, Sukumar began tests in mouse models three years ago by using a chemotherapy drug called doxorubicin. The mice were bred to develop breast cancers that were genetically similar to treatme...Penn study identifies patients most at-risk for secondary strokes
...crancial stenotic artery than other groups. "Our observations suggest that potential intervention should be considered very soon after clinical presentation, unless early intervention also increases the short-term risk," says Kasner. "Intracranial stenting has not been evaluated in a controlled clinical trial a......o delivering indicated diabetes services. Based on observations of office visits for 211 patients with type 2 diabetes, the researchers found that needed diabetes services were less likely to occur during encounters for acute illness, the percentage of indicated services delivered increased as the duration of vis...