Study is first to implicate dietary fat in 'fatty liver'
... livers of NAFLD patients accumulated fat, but its origin was unknown. The new work implicates fat from the diet as one cause of NAFLD and shows that fat buildup in the liver results when the liver loses its ability to manage the various influxes of fat that occur during transitions between the fasted and f...Human eggs can develop from ovarian surface cells in vitro
...d cast doubt on the established dogma on the fetal origin of eggs in adult human ovaries. It is now well established that fetal mammalian eggs originate from somatic stem cells. More recent research of adult human ovaries has shown that oocytes and granulosa cells (the layer of small cells that form the wa...Innovative study finds way to 'bio-synthesize' an anti-cancer compound
...the first time, we have demonstrated the bacterial origin of a natural product from tunicates, an important source of marine drug candidates." He added that the study "demonstrates how genomics can assist natural products chemistry and work towards sustainable production of important marine drug candidates ...Leprosy genome tells story of human migrations, French researchers report in Science
...y a single source of the bacterium that was at the origin of this global pandemic," Cole said. Each of the four SNP combinations was most common in a certain geographic region, allowing the researchers to trace how the pathogen had spread from its original source....Sex differences in the human brain
... Hurd 09.15 - 09.45 Arthur P Arnold: The neural origin of sex differences in the brain. Department of Physiological Sciences, UCLA, USA 09.45 - 10.15 Donald Pfaff: Differences in transcript levels in specific regions of male and female brains during the period of CNS sexual differentiation. Labora...Other highlights in the May 18 JNCI
...lood levels of androgens of adrenal and/or ovarian origin or of estrogens have an increased risk of breast cancer. Studies of premenopausal women, however, have produced unclear results. To examine the relationship between premenopausal blood concentrations of sex steroids and subsequent breast cancer risk,......ividuals with the X-fragile mutation was of Basque origin though they had mental backwardness or autistic ch...population and which may be of a relatively recent origin thus explaining the absence of the X fragile syndrome amongst this population. With this conclusion...MicroRNA study opens potential revolution in cancer diagnosis
...tumor samples of histologically uncertain cellular origin (but which had been determined by the anatomical location). Again, the miRNA classification provided amazing accuracy, especially compared techniques relying on messenger RNA (mRNA) expression patterns. Although this is a preliminary study, its vali...UCI researchers create method for predicting most effective use of cancer-fighting drugs
...is is important because a good knowledge about the origin of cancer cells' resistance to drugs is the first step towards more effectively breaking this resistance," said Komarova, assistant professor of mathematics with a joint appointment in ecology and evolutionary biology, and the first author of the pap...Study examines characteristics of cancers of the esophagus
...in the article. But there is controversy about the origin of tumors located at the far end of the esophagus where it connects to the stomach. Two distinct cancer types arise there. One type is associated with Barrett mucosa and that it is caused by reflux is widely accepted, the authors write, but the secon...Melanoma research receives a massive funding boost
...Melanoma cells that have spread from their site of origin are notorious for being resistant to cancer treatment such as chemotherapy and radiotherapy" says Professor Richard Kefford, Chief Investigator of the successful Sydney Melanoma Unit NHMRC grant and researcher at Westmead Millennium Institute. "These...Chronic sinus infection thought to be tissue issue, Mayo Clinic scientists show it's snot
... against what has been thought worldwide about the origin of chronic sinus infection: that inflammatory cells break down, releasing toxic proteins into the diseased airway tissue," says lead researcher and Mayo Clinic ear, nose and throat specialist Jens Ponikau, M.D. "Instead we found that these toxic prot...Report reveals high rate of heart attack amongst ethnic minorities in Scotland
...heart attack amongst Scots of Indian and Pakistani origin is 60-70% higher when compared with non-South Asians, a new report led by the University of Edinburgh has shown. Researchers say that the health of ethnic minorities in Scotland can now be better assessed and improved as census information can be li......orebrain that regulates emotion and memory, as the origin of fear memory. "This is critical as it changes how and where scientists thought fear was developed," says Zhuo, the EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health. "By understanding the biomolecular mechanisms behind fear, we coul...Left handedness may be linked to increased risk of breast cancer
...ctors hardly affected the overall association. The origin of the association may lie in exposure to high levels of sex hormones before birth, which can induce left handedness as well as changes in breast tissue, say the authors. "Although the underlying mechanisms remain elusive, our results support the hyp...Fever of unknown origin: a marker for occult cancer?
...RIGIN: A MARKER FOR OCCULT CANCER?Fever of unknown origin might be a marker of occult cancer, according to r...ne today by THE LANCET ONCOLOGY. Fever of unknown origin is characterised by a fever of more than 3 weeks duration, temperatures of more than 38.3C and a fai...Liver CRP production linked to atherosclerosis
...C-reactive protein in atherosclerotic lesions: its origin and pathophysiological significance," appears in the October issue of The American Journal of Pathology and is accompanied by a commentary. C-reactive protein (CRP) is a hallmark of inflammation and tissue damage, as in arthritis or infection. It ...Old mystery solved, revealing origin of regulatory T cells that 'police' and protect the body
... The answer, in turn, ends an intense hunt for the origin of regulatory T cells that has been under way for years. Reporting in the Aug. 25 issue of Nature, researchers at The University of Texas M. D. Anderson Cancer Center found that Hassall's corpuscles produce chemical signals that instruct dendritic ce...Subtypes of ependymomas arise from rare stem cells in the nervous system
...m used to identify populations of RGCs as cells of origin of ependymoma could also be used to identify cancer stem cells for other solid tumors, according to Helen Poppleton, PhD, an associate scientist. "That new knowledge could lead to the development of new drugs that significantly improve the outcomes o...Iressa does not improve survival for patients with the most common form of lung cancer
... median survival by 4 months for patients of Asian origin and by 2.8 months for patients who had never smoke...e was an increase in survival in patients of Asian origin and in patients who never smoked. We now need to find pragmatic ways of identifying which patients a...