New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
...ion factor that participates in a stress-signaling pathway to protect cells from damage. In a paper published...based on this discovery. He believes that the XBP1 pathway can be targeted in patients receiving treatment to ensure their tumors do not become resistant to th...Penn study finds pro-death proteins required to regulate healthy immune function
...ign antigens initiate a calcium-mediated signaling pathway that ends in cell differentiation and growth. The Penn scientists discovered that in the cells that lack the pro-death proteins Bax and Bak, calcium signaling is disrupted and energy production is reduced. Restoration of Bax corrects the signaling pr...Chromatin remodeling complex connected to DNA damage control
...ion of Cell. This connection between a signaling pathway crucial to DNA damage control and a pathway known as chromatin remodeling "opens an entirely new category of targets for potentially attacking c...Pathway links inflammation, angiogenesis and breast cancer
...n of the journal Cell. "This is a completely new pathway for inflammation-induced cancer and may provide ne...ing protein complex, which frees a cancer-inducing pathway to generate new blood vessels to supply tumors. The chain of events, painstakingly worked out by H...Reductive stress linked to heart disease
...eagues found increased activity of the biochemical pathway leading to high levels of reduced glutathione in t...ddressed through new drugs that target the genetic pathway causing the problem, according to Benjamin. This field of medicine has not appreciated reductive s...Stanford researchers find culprit in aging muscles that heal poorly
...l sciences. "We had no idea that the Wnt signaling pathway would have a negative effect on stem cell function...being placed in an aged environment - that the Wnt pathway came to light. The work was done with live mice whose circulatory systems were joined, and in lab di...Penn researchers discover novel pathway for increasing 'good' cholesterol
...to raising levels of good cholesterol (HDL-C). The pathway by which these proteins are able to achieve an inc...ll vertebrates. Jin and Rader expect that the same pathway for controlling HDL-C will apply to humans. The next step is to study how the genes for the PCs,...Metabolic study in mice could lead to 'good cholesterol' boosters
... a publication of Cell Press. Should the metabolic pathway uncovered in mice operate similarly in humans, the...ther investigation will examine to what extent the pathway is preserved in humans, Jin said. The authors will also look for chemicals capable of modifying the ...New oxidation methods streamline synthesis of important compounds
...dent Kenneth J. Fraunhoffer describe the catalytic pathway they used to synthesize a derivative of the chemotherapeutic reagent acosamine. They were able to eliminate all of the functional group manipulations and cut by one-half the number of steps required, while maintaining the same purity and yield. Whi...Physician and congressional leaders convene on Capitol Hill
...redictable Medicare payment updates and provides a pathway to repeal of the SGR, said John Tooker, M.D., CEO,...ystem, even with congressional interventions, is a pathway to decreased participation in the Medicare program and, ultimately, decreased accesses to health car...'Cars' imaging reveals clues to myelin damage
...y how the disease initially begins," he said. "The pathway is not clear." Purdue researchers used an imagin...lin called lipids. "It is possible that the same pathway causes myelin degradation in people suffering from multiple sclerosis and spinal cord injuries," Che...Emergency department guidelines enhance quality patient care
...physicians to use for every aspect of the patients pathway through the emergency department, says Stewart Wright, MD, assistant professor of emergency medicine. The development and results of the initiative, called the Committee for Procedural Quality and Evidence-Based Practice (CPQE), are reported in th...New mangosteen research establishes xanthone measurement standard
...e how many xanthones are actually absorbed and the pathway they travel. Study director Susan McPherson, MSc, senior research scientist at Charles River Laboratories, said preliminary research findings demonstrate that the proprietary whole fruit formula in XanGo Juice leads to high levels of xanthone absorp...High-Need Physician Workforce Incentives Act endorsed by American College of Physicians
...ntroduced two other bills, one that would create a pathway to eliminating Medicare cuts from the Sustainable Growth Rate (SGR) Formula and another that would provide grants to new primary care residency programs. ACP looks forward to working with Rep. Burgess and other members of Congress on legislation tha...USC researchers show that molecular markers predict tumor recurrence
...irst to demonstrate that genes in the angiogenesis pathway play a critical role in tumor relapse, says Heinz-Josef Lenz, M.D., professor of medicine at the Keck School and the principal investigator on the study. These molecular markers not only help us to identify patients who are at high risk, but they may...Once-fatal metabolic disorders treatable, says Stanford/Packard researcher
...m, the better the possible outcome." Alternative pathway therapy includes a combination of two drugs that work to help the body rid itself of excess nitrogen: sodium phenylacetate and sodium benzoate. Metabolic disease expert Saul Brusilow, MD, at Johns Hopkins' Children's Center, pioneered the drug combin...In utero exposure to smoking by mother can increase risk of ADHD
...s either or both of two specific forms of dopamine pathway genes (DAT and DRD4), and was exposed to cigarette smoking in utero, the risk for having combined type ADHD (many inattention and hyperactive/impulsive symptoms) increased 3 to 9 fold." John H. Krystal, M.D., Editor of Biological Psychiatry and aff...Study reveals aspirin's colorectal cancer prevention mechanism
...refore we hypothesized that, if blocking the COX-2 pathway was the mechanism underlying aspirin-associated risk reduction, it should preferentially reduce the incidence of those tumors that rely on COX-2." To investigate that theory, the research team compiled data from two ongoing prospective research s...Erectile dysfunction and lower urinary tract symptoms
...es have also suggested a connection between the NO pathway in bladder and prostate smooth muscle regulation which may benefit benign prostatic hyperplasia (BPH) patients. In a randomized, double-blind, placebo-controlled study, German researchers in Munich, Hamburg and Wuppertal tested the efficacy of varde...... puzzle. They have pieced together a direct linear pathway connecting three molecules involved in synaptic fo...search scientist in her lab, use the rodent visual pathway as an accessible model for studying how the signaling properties of synapses change during developme...