Rosenzweig to head Leducq Foundation cardiovascular research grant
...of the role and interactions of specific metabolic pathways in the development of heart failure; to use a genomics-based approach to investigate cardiomyocyte metabolism; and to directly test the relevance of these observations to human heart failure and insulin resistance. The four other American investigat...NHLBI awards 12 Women's Health Initiative contracts
...se WHI participants, they hope to explore biologic pathways by relating treatments, blood levels, and genes to breast cancer. "Genome-wide Association Study to Identify Genetic Components of Hip Fracture, Ohio State University, Columbus, OH, Rebecca Jackson, M.D. Dr. Jackson and colleagues will seek to i...10 outstanding scientists chosen as First Environmental Health Science Fellows
...ent, especially how toxic substances alter genetic pathways leading to birth defects. Abby D. Benninghoff, Postdoctoral Fellow, Oregon State University, uses her background in marine science and biochemical toxicology to understand how pollutants can interfere with crucial chemical signaling messages in c...Common anesthetic may induce cell death, generation of Alzheimer's-associated protein
...ne. Overall, the study's results define molecular pathways by which isoflurane induces deposition of A-beta, both directly and via caspase activation, and by which A-beta deposits lead to further caspase activation and apoptosis. "Even though our findings and those from other studies suggest that isofluran...Society for Research in Child Development Biennial Meeting
...might interest reporters include: Childrens pathways to political violence and terrorism International research on the outcomes of children adopted from China Child development in the rural poor first time data to be presented from the Family Life Project Childrens understanding of truth and lies ...Bombs and bodies: Children living in extremes
...nd recovery of children and families; and cultural pathways and community settings that mitigate the impact of dangerous events and promote resilience....New insights into autoimmunity and depression
...y.com/journal/arthritis ), shed light on the brain pathways of depression in general and in central nervous sy...the mechanisms underlying the limbic and olfactory pathways in depression. Imaging studies both in patients with clinical depression and patients with SLE could...National Institute of Dental and Craniofacial Research activities
... compelling opportunities in three main areas: new pathways to discovery, research teams of the future, and re-engineering the clinical research enterprise. The NIH recently announced the launch of a national consortium that will transform how clinical and translational research is conducted, ultimately enabl...Genetic pathways to curable and incurable forms of pancreatic cancer identified
...esearchers started out studying the common genetic pathways to pancreatic ductal adenocarcinoma in hopes of finding clues to developing early detection biomarkers and possible treatments to halt the progression of the disease. The work involved activating the pancreatic cancer oncogene called Kras and then se...Study questions 'cancer stem cell' hypothesis in breast cancer
...netically identical tumor cells. Moreover, several pathways and genes required for normal stem cell function are activated in cancer cells and play essential roles in the development of tumors. According to the cancer stem cell hypothesis, the few self-renewing stem cells that fuel the cancer are difficult...Long-term aspirin use associated with reduced risk of dying in women
...and cancer through its effect on common pathogenic pathways such as inflammation, insulin resistance, oxidative stress [damage to the cells caused by oxygen exposure] and cyclooxygenase (COX) enzyme activity," also linked to inflammation, they write. Because the study looked at women who made the decision t...Latest IPCC report highlights need for integrated climate/human behavior models
...s--can, when inserted into alternative development pathways at specific locations, offer decision-makers insight into climate risks calibrated in many different metrics (such as millions at risk of hunger or water stress in addition to economic damages)." "When also cast into the context of alternative miti...Green tea compound may be a therapy for people with rheumatoid arthritis
...s inflammation in the joints. The cell signaling pathways that regulate levels of these immune system molecules under both normal and rheumatoid arthritis situations are well studied, and the researchers were able to trace the effects of the green tea compound infusion to see that it worked by inhibiting th...Green tea compound suppresses factors causing cartilage, bone destruction in arthritis
...s inflammation in the joints. The cell signaling pathways that regulate levels of these immune system molecules under both normal and rheumatoid arthritis situations is well established, and the researchers were able to trace the effects of the green tea compound infusion to see that it worked by inhibiting...New animal study may explain why alcohol consumption increases breast cancer risk
...ehyde; oxidative damage; and one-carbon metabolism pathways through reduced folic acid. Methodology To date, there has not been an animal model that faithfully mimics the human disease with respect to characteristics of breast cancer, immunocompetence, and physiologically relevant EtOH intake. The resear...Your brain and hormones may conspire to make you fat
...These early factors may alter development of brain pathways which regulate energy homeostasis (balance). Once the tendency to obesity develops, it can be nearly impossible to reverse weight gains. However, these early factors can be manipulated to provide a more desirable outcome and may hold promise for prev...Molecular marker may help identify pancreatic cancer, and possibly predict survival time
...lity of miRNAs to affect multiple genes in various pathways make them a logical target for investigation of novel antitumoral therapies. However, these preliminary data will first need to be validated in other studies," the authors write. (JAMA. 2007;297:1901-1908. Available pre-embargo to the media at ww...Recommended doses of ginseng, ginko biloba do not interfere with drug absorption
... drugs in the cocktail provide measurements of the pathways that determine the pharmacokinetics of over 90 percent of prescription drugs. The scientists then measured the presence of these drugs or their metabolites in each subjects blood and urine in order to establish a baseline for how each individual abso...Forensic pathologists tell physiologists what they know about death and what puzzles them
...at some infants have immature development of nerve pathways in their brains. More research is needed to be able to identify SIDS at autopsy and to prevent more of these deaths. Deaths associated with drug abusePeople who have a history of chronic abuse of cocaine and opiate drugs have an increased risk of d...Stanford researchers identify immune dysfunction in melanoma patients
...'t working properly but didn't know which genes or pathways were involved in that failure. Finding the disruption in the cancer cells' interferon response could help in the development of vaccines to treat cancers. "We think this is a dominant way that immune dysfunction occurs in people with cancer," said ...