Researchers discover novel pathway of inflammation that contributes to lung damage in CF patients
...t for more specific regulation of the inflammatory pathways that ultimately contribute to lung damage in CF. Modulating this pathway could lead to a safer and more effective anti-inflammatory therapy for CF and perhaps other inflammatory lung diseases." Dr. Pilewski also is co-director of the Adult Cystic Fib...Animal research suggests new treatment target for epilepsy
... researchers learned more about the possible brain pathways involved in absence, or petit mal, seizures and tested a drug that revealed a potential new target for blocking seizures before they spread. "Many current therapies act on the entire nervous system and can have such side effects as sleep disruptions,...Nature publication reports key links between mechanisms of aging and metabolic disorders
...scovery describes the intimate links between these pathways of aging and those of metabolic disease, such as t...he essential connections between metabolic disease pathways and aging. The potential of this research is profound: Modulating these pathways may not only unco...Notch protein signaling directs early T-cell development
...nding on the biochemical context, it turns certain pathways on, and others off. "To the extent that we know where, and in which cells Notch is acting, we may be able to figure out how Notch works in the thymus," says co-lead author Arivazhagan Sambandam, PhD, Research Associate, also in the Department of Path...Potent spice works to block growth of melanoma in lab test
...that is also involved in tumorigenesis. Both these pathways play a central role in cell survival and proliferation." He said that an ability to suppress numerous biological routes to cancer development is important if an agent is to be effective. "Cells look at everything in a global way, and inhibiting just ...Ingredient that makes curry yellow effective against melanoma cells
.... However, it did not suppress two other signaling pathways associated with melanomas and tumor proliferation, B-Raf/MEK/ERK and Akt pathways. "Based on our studies, we conclude the curcumin is a potent suppressor of cell viability and inducer of apoptosis in melanoma cell lines," said the authors, adding "Fu...Eight million dollar commitment to schizophrenia research
...p will capitalise on those strengths and build new pathways to advance scientific knowledge and ultimately, treatments," he said. Executive Director POWMRI, Professor Peter Schofield, is a highly respected researcher with a strong track record in mental illness research. He also has been involved with NISAD s...Penn named a 'Breast Cancer Center of Excellence' by Department of Defense
... By identifying the critical molecular targets and pathways by which breast cancers progress, the researchers hope to develop more effective therapies against highly aggressive forms of this cancer. In addition, non-invasive imaging will likely aid in the identification of aggressive tumors, as well as early ...Major NH&MRC grant will fund multidisciplinary research to improve the treatment of neuroblastoma
...asis of neuroblastoma by identifying key genes and pathways associated with its initiation and perpetuation; understand the failure of specific biochemical signalling (retinoid) in defective cell differentiation; identify cancer-specific genes in neuroblastoma that are good candidates for the development of...Penn study shows genes may affect response to different quit-smoking medications
...dence that genetic differences in the brain-reward pathways of smokers may reveal whether they would benefit more from Zyban© or nicotine replacement therapy as an aid to quitting smoking," said lead author Professor Caryn Lerman, PhD, Director of the TTURC and Associate Director for Cancer Control Popul...New study shows SARS can infect brain tissue
...fic inhibitors that interfere [with] the signaling pathways involved," Dr. Jiang said. "Other approaches, such as neutralizing antibodies [and] specific binding peptides, could be tried to block brain damage induced by Mig." Four to five percent of SARS patients treated at the Guangzhou Institute of Respirato...American Neurological Association 130th Annual Meeting in San Diego
...sorders have begun to identify common steps in the pathways to degeneration. In the Wednesday morning symposium, participants will review the state-of-the-art in neurodegenerative diseases and discuss efforts underway to design treatments....Penn researchers discover a molecular pathway that leads to recurrence of breast cancer
...ce, as well as ways of targeting Snail's signaling pathways as a possible therapeutic approach to prevent recurrence....Yale School of Medicine Neuroscientist receives Javits Award
...nd signal transduction, to further study signaling pathways and loss of function studies in animal models of disease. "This award will provide substantial resources to continue our investigations of axon growth and guidance in the brain," Strittmatter said. "We are hopeful that insights gained from these stu...Mayo Clinic Cancer Center receives SPORE grant for breast cancer research from NCI
... to be funded by the SPORE include: Investigating pathways involved with development of breast cancer and prediction of response to chemotherapy Investigating inherited alterations in genes to determine those which predispose women to breast cancer Developing a vaccine that could effectively treat as many...BIDMC investigators receive award to study pathways responsible for obesity, type 2 diabetes
...roject Award for their investigations of the brain pathways that regulate body weight and glucose metabolism, ...gators working to elucidate the hormones and brain pathways regulating body weight and glucose metabolism; this funding will enable us to move one step closer t...Poor health literacy associated with poorer physical and mental health
...study," the authors suggest. "Although the causal pathways between low health literacy and disease-specific health outcomes remain unclear, this study provides further evidence of the likelihood that inadequate health literacy detrimentally affects health," the authors conclude. "To develop appropriate and r...Mayo Clinic research collaboration discovers why some DNA repair fails
... of DNA. As cells grow and divide, mismatch repair pathways are responsible for identifying irregular growth patterns and repairing specific irregularities in DNA. Wrong Place at the Wrong Time Dr. McMurray's group studied a specific mismatch repair protein Msh2-Msh3 and found a paradox: Instead of helping ...New model shows gender differences in high blood pressure, Jefferson scientists find
...ping to "begin seeing what receptors and signaling pathways might be involved in hypertension with elevated GRK5 levels." What they found surprised them. "There are not too many molecules shown in mice to raise basal blood pressure straight up," she says. "The effect is quite profound. There are a lot of ch...The 'upstairs/downstairs' mystery of cell suicide is burdened by too much evidence
... contributes to the confusion over which signaling pathways are most important for triggering this process, ac...gn definitive treatments until we understand which pathways leading to apoptosis are the most important," Green said. The major event in apoptosis is the break...