JCI table of contents: December 1, 2005
.... However, as the animals grow older, compensatory pathways in the brain may develop to adjust for the loss of ghrelin's effect on food intake, thus making these animals susceptible to obesity as they age. If these effects are reproduced in humans, they may suggest that children exposed to a high-fat diet mig...Pain and its impact on the treatment of rheumatic disease
... Inflammation also plays a role in activating pain pathways that usually lie dormant comprising as many as one-third of the total number of pain-transmitting nerves. What's more, molecular evidence suggests that stress and depression may increase a rheumatic patient's production of pain-provoking inflammato...New Stanford tool for genetic data analysis may improve cancer treatment
... future studies. These groups represent biological pathways that are characteristically active or inactive within tumors. In the first test of Tibshirani's new tool, he and his colleagues James Brooks, MD, associate professor of urology, and Hongjuan Zhao, PhD, research associate, studied the most common form...Groundbreaking guidelines promote early detection
...rgical and catheter-based therapies; and Clinical pathways and treatment algorithms to guide clinical decision-making. The Guidelines have been developed not just for specialists who perform the complex procedures used in the treatment of peripheral arterial disease, but also for primary care physicians, n...Toward the future of cancer prevention
...armful environmental exposure, and these molecular pathways are all under genetic control, she says. "In our g... show that 15-lipoxygenase-1 and related signaling pathways are at least as important as COX-2 to the workings of Celebrex and other NSAIDs. "M. D. Anderson is ...Understanding fatigue in chronic liver disease
...is understood about how these changes occur or the pathways involved. In a study led by Steven M. Kerfoot of the Immunology Research Group at the University of Calgary in Canada and published in the January 2006 issue of Hepatology, researchers speculated that cholestatic liver damage may be associated with a...Two pathways found that lead to Alzheimer's disease
...author of the study. "Now we can investigate these pathways and develop treatments that, we hope, may slow or stop the progression of Alzheimer's." Alzheimer's disease affects as many as 10 percent of people older than 65, and delaying or preventing the onset of dementia is an important medical priority. "We ...AACR supports new FDA clinical research guidelines
...ssues in translational research, providing defined pathways for introducing the latest innovations for cancer into human clinical trials, and attempts to modernize standards across clinical sites," he added....Mayo Clinic collaboration discovers protein amplifies DNA injury signals
... lesions. In healthy situations, DNA repair signal pathways are competently monitoring for damage and alerting...ar role in the cell. "If we can understand all the pathways involved in signaling the DNA repair process, we may be able to develop a comprehensive approach to ...Web model of influenza-host lifecycles will aid scientists in creating anti-viral drugs
...ated in 2004 and includes a variety of biochemical pathways for processes such as cell death in several species, primarily human. Individual reactions are shown as separate items, which are linked by arrows to associated reactions. The diagrams resemble constellations; hence the "starry sky" nickname. The inf...Researchers break chain of biochemical events that brain cancer cells use to evade therapy
...design therapies that interact within the critical pathways that are important for cancers to survive," said K... scenario is that we will need to develop multiple pathways for interaction. The understanding we gain from translating basic research into patient care allows ...New, expensive, widely-used drugs continue to cause liver problems, says Jefferson liver specialist
...dies need to be done to uncover specific metabolic pathways involved in drug-caused liver injuries, Dr. Navarr...he pharmaceutical industry wants to identify these pathways to try to avoid them. "The issue of acetaminophen and other drugs causing liver problems has been ar...U of M reaches milestone in diabetes research using pig islets
...vestigator. "Now that we have identified critical pathways involved in immune recognition and rejection of pig islet transplants, we can begin working on better and safer immunosuppressant therapies with the eventual goal of bringing the treatment to people." This unprecedented progress on islet xenotranspla...NIH grant to support research on new treatment for severe OCD
...ns are at the intersection of many important nerve pathways related to OCD. In the early 20th century, a surgical procedure called frontal lobotomy was used to treat severe psychiatric disorders. These approaches, while helpful, often blunted a patient's personality. The misuse of this procedure combined w...Scientists find variants of blood clotting genes increase risk of coronary disease
...designing new therapies that target blood clotting pathways to help prevent heart disease. More generally, they suggest that bigger and deeper studies than have been customary will be needed to identify the genetic causes of heart attacks." (Quote by e-mail; does not appear in published paper)...Researchers use embryonic model to reprogram malignant melanoma
...distributing along the neural-crest-cell migratory pathways throughout the chick embryo. The investigators found that a subpopulation of the invading melanoma cells produced markers indicative of skin cells and neurons that had not been present at the time of transplantation. Taken together, results of thi...Scientific study of recovery process sheds new light on role of spirituality
... adds, "There are religious, secular and spiritual pathways to long-term addiction recovery. Charting the commonalities and distinguishing features of these pathways is enriching our ability to help individuals, families and communities." "Research on recovery is li...International award honors M. D. Anderson President for pioneering research
...gent which inhibits critical biochemical signaling pathways in cells and in human cancers growing in mice. Men...ans of an agent that blocks the cellular signaling pathways regulated by growth factors. The FDA approved Cetuximab for treatment of advanced colorectal cancer ......ortant gene will increase our understanding of the pathways involved in brain development and determine how aberrations in the pathway involving ASPM result in microcephaly," said Dr Bond. Other groups in the section of ophthalmology and neuroscience work on inherited blindness (Professor Chris Inglehearn) th...Improving recovery from spinal cord injuries: $3.7 million grant will create rehabilitation network
...lifelong ability of the brain to reorganize neural pathways based on new experiences.) The network will also coordinate sabbatical and pilot grant programs for visiting research scholars who are poised to become strong independent investigators in the field. It will sponsor various educational opportunities...