New strategy developed to study disease: Reveals insights into cancer and treatment leads
...cancer cells. Previously the role of Src in these pathways was controversial. "Understanding the functions of different proteins in normal states and disease states is crucial for treatment development because it can help identify new therapeutic targets," says Cole. Insights into tyrosine kinases could be ......bilities. Only a few enzymes in certain metabolic pathways are really necessarily to keep Salmonella bacteria alive. Most of these essential enzymes are missing in other important pathogens, or they are also present in the human organism, so they cannot be considered possible points of attack for new broad-s...Research mice help scientists understand the complexities of cholesterol
...improved. "The animals can help us determine which pathways are affected by drug therapy, which can eventually be translated to human studies," said Parks. "They are a valuable tool in the quest to find a therapy to raise HDL concentrations and retard the development of heart disease." Parks's colleagues on t...Hopkins study shows low-dose aspirin suppresses clumping of blood platelets in both sexes
...wo-week period, works by inhibiting key biological pathways that lead to platelet clumping. Using an electri...was largely suppressed in at least three other key pathways related to their function when platelets were stimulated with substances that normally trigger clot ...'Executive' monkeys influenced by other executives, not subordinates
... -- in the brain. We can begin to trace the neural pathways by which social information feeds into the structures that control the eyes. And, we can explore whether such influences as hormonal levels, particularly testosterone, influence ranking. For example, we can manipulate testosterone levels, or give anx...Reduced insulin in the brain triggers Alzheimer's degeneration
... Both insulin and IGF-I activate complex signaling pathways downstream, prompting energy metabolism and growth required for learning and memory, and inhibition of oxidative stress, which unchecked could trigger neurodegeneration. As insulin was depleted, neurons died and the brain dropped to half its size, a ...Study demonstrates that lung cancer susceptibility runs in families
...fluenced by genetic factors, because genes control pathways common to a number of cancers." Such marked cancer susceptibility also likely explains why patients in this study, who never smoked but might have been exposed to secondhand smoke, developed lung cancer in the first place, she says. Gorlova will pres...Research suggests that immune response protects against brain tumor development
...f GBM among those who used them. "There are three pathways that lead to inflammation in the brain, and reducing one with a Cox-2 inhibitor may be beneficial," Bondy says. "These are all interesting signals that may give us a clue as to the role of inflammation and development of different kinds of brain tumo...JCI Table of Contents, April 3, 2006
...otection from infection: how antioxidant signaling pathways can help In a study appearing in the April issue of the Journal of Clinical Investigation, researcher Shyam Biswal and colleagues at the Johns Hopkins University in Baltimore report that mice that fail to express Nrf2, a protein involved in the expr...The $6 billion (hu)man is becoming reality, as bionics restores or expands humans' abilities
...r. Craelius and his colleagues uses existing nerve pathways to control individual computer-driven mechanical fingers. Dextra consists of a standard plastic socket and silicone sensor sleeve that encases an amputee's limb below the elbow. After a brief training period, operating the fingers is biomimetic, th...Researchers identify potential targets for new pain therapies
...s team is working to identify all of the molecular pathways responsible for making neurons more sensitive to pain signals. They hope to develop more specific targets for analgesic drugs that might work differently than opioids, which often require higher doses for subsequent treatments to produce the same eff...Assessment model gauges lung cancer risk based on medical history and genetics
... variables such as genetic variations in important pathways and more environmental risk factors will be added in the future. "Early detection is key to successful treatment of any cancer, and this model is designed to help physicians identify and screen those patients most at risk for lung cancer," Spitz add...Daniel Rader, MD, of PENN, selected to direct a 2006 'Freedom to Discover' biomedical research grant
...anslational research in applying basic research in pathways of cholesterol metabolism and atherosclerosis to the development of new therapeutic approaches to reduce heart disease risk. He is especially well known for his work in novel approaches to boosting HDL (good cholesterol) levels and function. At Penn...Commonly used blood pressure medication prevents aortic aneurysm in mice with Marfan syndrome
...s genetic origins to its mechanistic or biological pathways and finally to its treatment. In the latest experiments, which took three years to complete, Habashi says the science of genetics was used to create animal models with the disease, which could then be studied. The disease was then broken down into...Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice
...out more about the function of Hap1 and the neural pathways it employs, a team of scientists from Emory, The Rockefeller University, the Burnham Institute for Medical Research, and the University of California, San Diego, conducted a series of experiments in mice. They found that fasting increased the level ...New research links metabolism and appetite suppression, opening door to obesity treatments
...inberg's research shows how CNTF activates similar pathways to those stimulated by exercise. "While hormones such as leptin were initially thought to be the cure-all for weight loss, they were later found to be ineffective in obesity due to the presence of proteins which inhibit their ability to stimulate fa...Lizard 'third eye' sheds light on evolution of color vision
...gustducin and Go each activate different molecular pathways that work against each other physiologically. Blue light and gustducin generate an "off" response in the nerve cell while green light and Go generate an "on" response. "It may seem strange to have two opposing signals in the same cell," says the stud...Technique could speed new medulloblastoma drugs
... technique could also be used to identify specific pathways in other types of cancer that might be vulnerable ...herapies, such as novel drugs that block signaling pathways that are abnormally activated. Such treatments could not only save lives but also eliminate the seve...Level of education completed linked with coronary artery calcium deposits
...ng and physical activity. The authors suggest that pathways and mechanisms linking education and subclinical disease remain to be further explored. "Fundamental changes in preventive measures very early in life are required to address social and economic disparities in health. In addition, integrated prevent...Education level linked with presence of coronary artery calcium deposits
...g, and physical activity. The authors suggest that pathways and mechanisms linking education and subclinical disease remain to be further explored. "Fundamental changes in preventive measures very early in life are required to address social and economic disparities in health. In addition, integrated prevent...