Study in Science holds promise for a new approach to drug therapy
...ed "drug candidates" can provide better control of pathways involved in pain relief, inflammation and heart disease, while leaving healthy functions in place. "We believe we have discovered a new class of drugs that could make current drugs more effective, but that also represents a completely new, independe...Blocking key protein reduces inflammatory markers in metabolic syndrome
...critical protein can improve multiple inflammatory pathways in patients with the metabolic syndrome a cluster of symptoms associated with increased risk of cardiovascular disease and type 2 diabetes. If supported in future studies, the findings may suggest new strategies for improving the cardiovascular ris...Study may explain why exercise helps heart failure patients
...es beneficially activation of several neurohumoral pathways that reflect the severity of heart failure, and that following BNP concentrations may be one way of assuring that long term exercise training programs are having beneficial effects in individual patients. Pending is evidence from large randomized cli...Small Business grant helps Chadwick Optical bring Schepens Institute invention to patients
...alf of the visual field due to damage of the optic pathways in the brain. Most commonly caused by strokes, it can also be the result of brain damage from tumors or trauma. A patient with this condition is unaware of what he or she cannot see and is frequently bumping into walls, tripping over objects or walki...JCI table of contents: May 1, 2006
...rsity further discuss the Cav-1regulated signaling pathways in ECs and conclude that "these data suggest that ...: AntiIL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis AUTHOR CONTACT: Daniel J. Cua DNAX Research Inc., Palo...M. D. Anderson: Setting the benchmark in brain tumor treatment
... a fleet of agents designed to disarm the numerous pathways brain tumors use to thrive will surely be a bumpy ... Such information will help identify the molecular pathways that cancer cells use to override normal growth controls. In the United States, all samples...Perfect timing: Cardiologists meet in Chicago during May's National Stroke Awareness Month
...ing. The carotid arteries in the neck are critical pathways for blood flow to the brain. Similar to arteries in the heart, they can become clogged with cholesterol deposits. Traditionally, clearing away deposits in the carotid arteries has involved major surgery. Today, a growing number of patients are instea...C-myc required by the immune system
...L- 15. "Very little is known about the signalling pathways that actually control IL-15-dependent homeostasis," explains LICR's Dr. H. Robson MacDonald, the senior author of the study. "By analyzing genetically engineered mouse models with reduced c-myc, reduced IL-15 or absent IL-15, we discovered that it's ...Study of nutrients' effects on brain provides insight into appetite regulation
... that very specific micronutrients may drive these pathways in the brain and could lead to a more scientific approach to diet design to help regulate body weight. The study, led by Randy Seeley, PhD, professor in UC's psychiatry department, appears in the May 12, 2006 issue of the journal Science. Ingesting c...First Canadian professorship in melanoma research established
...tment to research directed towards identifying key pathways in melanoma development that would lead to potential targets for prevention and therapy....Nobel Laureates featured in symposium in honor of new research center at NYU School of Medicine
...nce,The Rockefeller University Signal transduction pathways used by therapeutic agents and drugs...New mechanism explains glucose effect on wakefulness
...ibition, thus providing new insights into cellular pathways regulating vigilance states and energy balance," wrote Burdakov and colleagues. "These results provide evidence that the firing rate of orexin cells is sensitive to changes in glucose that correspond to fluctuations occurring normally during the day ...Treating obesity may improve the efficacy of therapy for hepatitis C
...f is linked to the disruption of hormone signaling pathways that affect cell function and to abnormal levels o...em. Increases in fat tissue may disregulate immune pathways peginterferon targets, rendering the drug ineffective. Second, obesity causes insulin resistance whi...Early results find activity in drug that turns on tumor 'death' receptors
...state and breast. The drug is designed to activate pathways inside tumor cells that lead to destruction of these cells. "Normally, the p53 gene regulates cell suicide in the presence of cell damage, such as that induced by chemotherapy and radiotherapy, but this gene is mutated - and therefore inactivated - ...Skin rash in patients treated for liver cancer determines survival
...vents two epidermal growth factors receptor (EGFR) pathways from becoming activated in cancer cells. The EGFR pathway has been implicated in the growth and spread of many cancers. When the researchers evaluated the toxic effects of treatment with lapatinib, they found that twenty of the patients treated had...Study explores correlation between education and the leading causes of preventable death
...nstead focuses on key health behaviors as specific pathways by which schooling can lead to differences in health outcomes," explain Donald Kenkel, Dean Lillard, and Alan Mathios. "The results suggest that completing high school yields large apparent health returns in the form of less smoking. Both men and wom...JCI table of contents, June 8, 2006
...rovides new insight into CaMKII and HDAC signaling pathways in the regulation of cardiac growth. TITLE: CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy AUTHOR CONTACT: Eric N. Olson University of Texas Southwestern Medical Center, Dallas, Texas. Phone: (214) 648-11...Study uncovers 'significant' functional differences of novel estrogen receptor
...dy said, "The estrogen and anti-estrogen signaling pathways mediated by this new receptor could explain why some breast cancers grow worse or become resistant to anti-estrogen therapy, specifically the drug tamoxifen, which blocks estrogen signaled responses through ER-a66 in breast tissue." According to the...The brain, hormones and behavior focus of briefings at international meeting June 19-22
...he development of the brain, when important neural pathways essential for behavioral and cognitive functions are formed. It's also when most kids are likely to try marijuana. According to animal research, such exposure can have negative and long-lasting effects on the brain. Meanwhile, a Michigan State Univer...UT Southwestern researchers identify roles of gene mutations causing lupus in mice
...k the disease by developing therapeutics targeting pathways activated by the mutated Ly108 gene," Dr. Mohan said. Kirthi Raman Kumar, the paper's lead author and a graduate student in immunology, said, "This is the first demonstration of how immature B-cells from lupus-prone mice behave differently from lupus...