'Aqueous Humor Outflow' featured in Investigative Ophthalmology & Visual Science
...issues. Understanding of the aqueous humor outflow pathways is imperative to understanding drainage problems in glaucoma. "The goal of this conference was to identify the most important unanswered research questions within the area of aqueous humor outflow pathways. Because of this opportunity and the work ...Serotonin receptor: A rheostat in brain for emotion that may be linked to depression
...order to better understand the specific biological pathways that contribute to risk for the condition as well as predict treatment response....Pitt to receive $8.4 million from NIH to determine best treatments for sepsis
...kers that are associated with the four fundamental pathways of sepsis-related organ dysfunction cellular hypoxia, oxidative stress, inflammation and coagulation/thrombosis; and cost effectiveness. Collaborations with experts in the field of emergency medicine is critical. The researchers note that gettin...Williams Syndrome, the brain and music
... evidence is in, we will have identified genes and pathways in the Williams syndrome deletion that underlie these drastic differences in modalities," she adds. Despite whole brain volumes that are about 15 percent smaller than normal, the temporal lobe, which lies above the ear canal and, among other things,...Three molecular triggers threaten leukemia patients
... leukemia will require blocking multiple molecular pathways that fuel the disease, researchers at The Universi... on the disease. "We found that the more of these pathways that are active in a patient, the worse their prognosis," says first author Steve Kornblau, M.D., as...Study identifies factors correlated with cerebral palsy
...ow to use the best science to understand potential pathways that would decrease the functional severity of CP." "With respect to ongoing management, a long-term whole-child focus that optimizes health, developmental, and functional outcomes, community participation, and family well-being is in order. In this...Scientists show drug can counteract muscular dystrophy in mice
...ome bigger, showing that one of the most important pathways the inhibitors use to create bigger muscles involves the activation of follistatin. "If you didn't have follistatin anymore, these drugs didn't work," he says. Moreover, Drs. Sartorelli's and Puri's groups were able to show that in normal animals, f...Study identifies possible mechanism for brain damage in Huntington's disease
...nockout mice found decreased activity in metabolic pathways known to be involved in mitochondrial function pathways also downregulated in human HD and brain samples from HD patients also showed reduced expression of...Mediterranean diet associated with reduced risk of Alzheimer's disease
...uggesting that the diet may work through different pathways to reduce Alzheimer's disease risk. The Mediterranean diet consists of high amounts of fruits, vegetables, legumes, cereals and fish, mild to moderate amounts of alcohol and low amounts of red meat and dairy products, according to background inform...Researchers identify new weapon to fight deadly bacterial sepsis
...d in cell cultures traced the specific biochemical pathways by which LPS triggers an inflammatory cycle that damages the cells of the heart. By blocking aldose reductase activity with pharmacological inhibitors or using small interfering RNAs (pieces of genetic material that specifically stop the production o...The Gerontological Society of America awards new Hartford Doctoral Fellowships
...sertation topic: "Regret and advice: Elder-defined pathways to successful aging." Barbara Thomas, MA, MSW University of Michigan Dissertation co-chairs: Ruth Dunkle, PhD, and Renee Anspach, PhD Dissertation topic: "The childhood shows the main as the morning shows the day: Three essays on childhood maltreatm...'Tribbles' protein implicated in common and aggressive form of leukemia
...epending on the biochemical context, turns certain pathways on and others off. Pear and colleagues knew from fruit fly studies that the Tribbles protein was linked to cell growth and cell-fate determination and is closely related to the Tribbles gene in mammals. In fact, Tribbles is so named because, when ...New recommendations for the diagnosis of Pulmonary Embolism
...l of Medicine, researchers describe the diagnostic pathways that can be used to achieve an accurate and safe diagnosis of PE. Based on the results from the Prospective Investigation of Pulmonary Embolism Diagnosis II (PIOPED II) and other studies, these guidelines include both evidence-based recommendations...Regulatory pathway in brain development possible basis for malformations
... co-factor in two distinct signaling or regulatory pathways that mediate neuronal differentiation. The new wo...ized," Hamilton said. "In particular, cell lineage pathways that are often thought of as independent of signaling once they are initiated may really be under ti...New research identifies gene important for nicotine's effects on the brain
...o suggests that future research focus on signaling pathways inside nerve cells and understanding which pathways are really important for nicotine addiction as opposed to other types of abuse. Picciotto's researc...Blood pressure drugs could help halt pancreatic cancer spread, Jefferson researchers find
...ze how angiotensin affects VEGF, and the signaling pathways involved," she says. Her team is looking at the effect of angiotensin on cell proliferation and programmed cell death, and would like to develop an animal model. "Patients have chemotherapy and radiation sometimes before surgery," she says. "I would...Mayo Clinic Cancer Center -- individualizing treatment for multiple myeloma patients
...ing one of two known NF-B (Nuclear Factor kappa B) pathways which keep cancer cells from self destructing the first-discovered, or canonical, NF-B pathway. But through extensive genetic examination of 42 unique multiple myeloma cell lines and tumor samples taken from 68 patients, the investigators defined mu...Bank on a Cure researchers identify pathways mediating myeloma treatment side effects
... myeloma, today presented data identifying genetic pathways that may explain why some patients suffer from blo...eatment with thalidomide for multiple myeloma. The pathways may shed new light on individual differences in the response to cancer and its treatment, and may le...Study explains how NSAIDs halt cancer growth
...ple, inflammatory bowel disease certain signaling pathways that modulate the inflammatory processes become "stuck" in an activated state. Among other outcomes, this course of events leads to the release of molecules that enhance carcinogenesis and tumor progression at the site of the damage. According to L...Scripps research combination therapy obliterates new vessel growth in tumors and retinopathy
...-angiogenic agents that target multiple angiogenic pathways can significantly increase the effectiveness of su...ivation of alternative compensatory pro-angiogenic pathways designed to stimulate new vessel growth, while the combination approach significantly reduced such c...