Tag: "peptide" at medical news

Alzheimer's disease prevention may be easier than cure

...t it is the accumulation over time of amyloid beta peptide 142 (Abeta42) that triggers changes in the brain that lead to cognitive dysfunction in Alzheimer's disease. The reduction of amyloid levels is therefore a major therapeutic objective. Todd Golde and colleagues from the Mayo Clinic Jacksonville report...

GroPep to pursue promising asthma drug following preclinical study results

...mpleted preclinical efficacy studies of its T-cell peptide drug candidate, in models of psoriasis and asthma....p has international patent coverage for the T-cell peptide technology. Listed biopharmaceutical company GroPep Limited (ASX: GRO) announced today that it had c...

Polymorphism and antibodies associated with highly increased risk of rheumatoid arthritis

...ositivefor antibodies against cyclic citrullinated peptide are much more at risk ofdeveloping rheumatoid arth..., and tested positivefor anti-cyclic citrullinated peptide (CCP) antibodies, all developedrheumatoid arthritis (RA) in the following two and a half years. Both...

JCI table of contents: January 19, 2006

...study suggests a risk of serious side effects with peptide vaccines A new study in mice appearing online on... authors show that the administration of synthetic peptide vaccines, designed to induce strong immune responses, can trigger serious, and sometimes lethal, sho...

Viral, gold nanoparticles can assemble themselves to potentially find and treat disease

... to the specially engineered virus that displays a peptide that matches a protein receptor "zip code" on the tissue of interest. This homing technique was pioneered by the lead authors on the current study, Pasqualini and Arap. Their previous work revealed that the human vascular system contains unique molec...

Receptor critical in neurodegeneration reduces Alzheimer's plaque

...s in the brain. One such change is deposits of the peptide beta-amyloid in brain plaques, a hallmark of the disease. Nerve fibers also play a crucial role in the neurodegenerative process of Alzheimer's disease. "We asked whether those mechanisms that regulate nerve fiber growth might lessen the Alzheimer's ...

How nice, brown rice: Study shows rice bran lowers blood pressure in rats

...Vitamin E, markedly lowered the rats levels of the peptide 8-OHdG. Oxidative stress plays an important role in the initiation and progression of cardiovascular diseases, explained lead author Ardiansyah [ editor note: name is correct as written, there is no first name ], a Ph.D. candidate at the universitys ...

Scientists one step closer to cancer vaccine

...e defence. The researchers have identified a short peptide molecule that the T cell in the study recognises. Using this peptide, the researchers can vaccinate and protect against the spread of tumours from different tissues, including melanoma, colon cancer, lymphoma, and fibrosarcoma. "So far we've only con...

Melanoma vaccine strategy shows promise in laboratory experiments

...tudy, the scientists used a small protein called a peptide found in approximately 70 percent of melanomas, bu...BRAFV600E peptide. Combining the prevalence of the peptide among melanoma patients about 70 percent with the number of patients whose immune cells are able t...

Physician experience related to accurate identification of third heart sound

...essure (LVEDP). Blood levels of B-type natriuretic peptide (BNP) were also measured in each patient. BNP is a neurohormone secreted from the cells of the heart in response to stretching of the heart walls and has been shown to be clinically useful in diagnosing heart failure. Patients with an S3 generally ...

Fighting inflammation with targeted liposomal therapy

...tic material directly into a cell. They chose RGD peptide liposomes to deliver a dose of dexamethasone phosp...y for rheumatoid arthritis patients. RGD peptide was selected for targeting of the liposomes based on its high chemical stability and its high affini...

Targeting the inflamed synovium

...at model, corticosteroids were encapsulated in RGD peptide liposomes targeted to bind to inflamed cells in the walls of blood vessels. The steroid treatment was delivered rapidly and worked effectively to reduce synovial inflammation, with no signs of the conventional side effects. Further pot...

Hormone can predict pulmonary hypertension and potential death or survival

...uring levels of a hormone called brain natriuretic peptide in individuals with serious lung disease can predi...many, and six associates studied brain natriuretic peptide (BNP) in the circulation of 176 consecutive adult patients with a variety of pulmonary diseases. The...

Fat cells around coronary arteries may play a role in heart disease

...ts of vascular endothelial growth factor (VEGF), a peptide that stimulates angiogenesis. Since epicardial fat tissue receives its blood supply directly from the adjacent coronary artery through the vasa vasorum, a network of tiny blood vessels near the outer surface of the heart, the Iowa team's results sug...

JCI table of contents, April 20, 2006

...dy as well as an intranasally-delivered proinsulin peptide synergizes to reverse recent-onset type 1 diabetes...greater efficacy than monotherapy with anti-CD3 or peptide alone. As the induced Tregs acted to specifically shield islets from autoimmune destruction, and onl...

Dynamic duo: Combination therapy reverses type 1 diabetes

...dy as well as an intranasally-delivered proinsulin peptide synergizes to reverse recent-onset type 1 diabetes...greater efficacy than monotherapy with anti-CD3 or peptide alone. As the induced Tregs acted to specifically shield islets from autoimmune destruction, and onl...

Study may explain why exercise helps heart failure patients

...by increasing the production of B-type natriuretic peptide (BNP). This neurohormonal activation, as it is cal... patients with higher levels of B-type natriuretic peptide have poorer prognoses. Drug treatments are often unable to adequately reverse the neurohormonal acti...

JCI table of contents: May 4, 2006

...critical loop of TNFR and RANK with a small cyclic peptide allows the inhibition of RANK ligandinduced bone b...modeling to demonstrate the exact region where the peptide binds and interferes with RANK signaling. These findings pave the way for the development of new str...

More than just genetics: Lifestyle choices impact GI health

... LGI-LGL breakfast increased levels of the hormone peptide YY on the morning after the breakfast. Peptide YY, which is produced in the stomach as a response to food, promotes satiety and tends to decrease food intake. Surprisingly, participants who consumed the HGI-HGL breakfast experienced more satiety an...

New compounds fight chronic symptoms of bowel disorders

...tide is an analog of the naturally occurring human peptide Glucagon Like Peptide-2 (GLP-2). GLP-2 is a peptide growth factor secreted in the distal intestine and is involved in regeneration, maintenance and repa...

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(Date:10/16/2014)... thinking on how the bowel lining develops and, in ... cancer starts. , The researchers produced evidence that stem ... that are a feature of the bowel lining, and ... development, a controversial finding as scientists are still divided ... technologies, Dr Chin Wee Tan and Professor Tony Burgess ...
(Date:10/15/2014)... , Oct. 15, 2014 Sandata ... for home and community-based care, today announced it ... implementing Sandata,s Santrax® Electronic Visit Verification™ Solution (EVV™) ... is a home health company founded in 1996 ... . The study details ...
(Date:10/15/2014)... bacterial pneumonia in female mice to an enzyme activated ... naturally more resistant to respiratory infections than males. Now, ... resistance to bacterial pneumonia in female mice is linked ... also show that this enzyme is ultimately activated by ... The team, lead by Professor Lester Kobzik at the ...
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