Important factors in compliance with HIV regimens identified; and more
...associated with lower viral loads during the acute phase of HIV-1 infection. PLoS Med 3(11): e441. PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://dx.doi.org/10.1371/journal.pmed.0030441 PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-03-11-tr...Innovative movies show real-time immune-cell activity within tumors
..."We've taken the first real-time look at the final phase of the immune system's response to cancer cells," says Wolfgang Weninger, M.D., an assistant professor in the Immunology Program at Wistar and senior author on the new study. "This has enabled us to delineate the rules of T cell migration and engagem...Vaccine for brain tumors shows promising results
...ine. Based on these preliminary findings, a larger phase 2 study is planned for 2007. Rosalind Hekkala, a 66-year-old woman from Reno, Nev., who was enrolled in the first study group, was originally diagnosed with a brain tumor in July 2005. She had surgery to remove it, but the tumor returned in November....New agreement questions NHS relation with industry
...aceutical product licensing). It does not apply to phase I testing with healthy volunteers (as in TGN1412), to studies initiated by investigators, to trials in which the sponsor merely provides funding, or to research in non-NHS institutions. While collaboration is admirable, we must realise that the dev...No benefit to mechanically opening arteries days after a heart attack
...heart attack, which was identified after the early phase of the heart attack. All of the patients were in stable condition. They were randomly assigned by computer to receive balloon angioplasty and stents plus medical therapy or medical therapy alone three to 28 days after their heart attack. Researchers ...Enbrel provides sustained clinical improvements for ankylosing spondylitis for up to 3 years
...at data from an ongoing open-label, multinational, phase 4 extension study showed that patients with ankylo...rapy. These results are consistent with an ENBREL phase 3 clinical trial at 24 weeks. The 160-week results will be presented at the American College of Rhe...Cost-benefit analysis: Combo treatment costs more, saves money later
...eal cancer between 1991 and 1996. That randomized phase III trial was designed to compare three treatment regimens--two combining radiation therapy and chemotherapy and one using only radiation therapy. "In overall survival rates, there was no significant difference among the three treatment arms," Konski...Bacteria could make new library of cancer drugs that are too complex to create artificially
...odiginine analogue called GX15-070 is currently in phase 1 and 2 cancer treatment trials. However, analogues of other prodiginines, such as streptorubin B, could be even more powerful anti cancer tools, but they cannot currently be easily synthetically produced on a lab bench. Professor Greg Challis and ...Lisdexamfetamine dimesylate in ADHD phase 3 data presented
... received six months of treatment in an open-label phase III study. Results also demonstrated that at 6 months, 95 percent of children taking lisdexamfetamine dimesylate (NRP104/LDX) produced a "much improved" or "very much improved" rating on the Clinical Global Impressions Improvement score. These resu...FDA approves prescription Zaditor for over-the-counter relief from itchy eyes
...the release of chemical mediators to stop the late phase allergic reaction Histamines, a chemical made by the body during an allergic reaction, are a primary cause of itchy eyes. Unlike most OTC drops, Zaditor blocks the histamines that cause itchy eyes and prevents the release of additional histamines...EMEA and FDA extend drug-label based on results of the EORTC 24971 trial
...re (docetaxel) was possible due to the EORTC 24971 phase III, open label randomized trial, involving 358 patients, evaluating the benefit derived from docetaxel - based combination in inoperable locally advanced head and neck cancer. Patients treated with the regimen prior to surgery or radiation had signi...Satellites help ensure safe sunning
... service has just completed its two-year-long test phase and has received positive feedback from users. "HappySun is a tool for the primary prevention of skin cancer," Franco Marsili, Director of the Dermatology Clinic at the Versilia Hospital in Italy, said. "The aim is to educate people about the intelli...Tipsheet: Focus on gait training, pain relief, pressure ulcers and hearing aid training
...an average of 41.7 mm of displacement during swing phase relative to stance phase. A rest period caused the limb to displace in the socket approximately 4.8 mm during subsequent walking trials, possibly reflecting limb enlargement and thus a more proximal position in the socket after the rest period. This ...Antipsychotic medications used to treat Alzheimer's patients found lacking
...ide effects are considered, according to the first phase of a large-scale clinical trial funded by the Nati... and reactions to the medication. In this first phase of the trial, patients were randomized to olanzapine (Zyprexa), quetiapine (Seroquel), risperidone (...Forget basal body temperature -- check out her clothes
...he women twice: once in their fertile (follicular) phase and another time in their non-fertile (luteal) phase. To ensure that only the women's attire, grooming and accessories were taken into account, researchers masked participants' faces in the photographs with black ovals. Researchers then arranged ...Overweight children at increased risk for adult cardiovascular diseases
...esent in the overweight children. "The childhood phase of chronic adult diseases is a dimension of health that has received little attention," states guest editor of the special focus issue, Dr. Bonita Falkner of the Department of Medicine at Thomas Jefferson University. "The concept of interrupting chro...Optics tests for early Alzheimer's diagnosis make significant advances
...have been tested in a Phase I trial in humans with phase III multicenter human clinical trials slated for next year. In the end, the tests could cost less than $300 per test, he says. As a potential early screening tool and confirmatory diagnostic technology, this is the ballpark range for a widely used te...Progesterone shows promise as treatment for traumatic brain injuries
...ical Treatment"), enrolled 100 participants. Their phase II study was primarily designed to evaluate whethe...search team is now planning a large, multi-center, phase III clinical trial designed to test the effectiveness of progesterone in 1000 patients with TBI and ...Italian public smoking ban leads to fall in hospital heart attack admissions in under 60s
...n and a more than 90% reduction in nicotine vapour phase concentration in pubs and discos suggesting that the smoking ban in Italy did reduce overall smoking, which was likely leading to the observed effect on AMI admissions. "The implications of the study for public measures of health are important. Wh...Scientists stop colon cancer growth in mice by blocking just one enzyme
...Srivastava said, since one candidate is already in phase 3 clinical trials in the United States for prolonged use in diabetes, and an aldose reductase inhibitor is already available for clinical use in Japan. Such drugs would likely be used after surgery as a "chemo-preventive" measure to keep cancer cells...