New treatments needed for irritable bowel syndrome
...in an uncontrolled trial, but how much of this was placebo response was unclear. Psychological treatments h...g effects in trials (10-15%) were smaller than the placebo effect (40-50%). Professor Spiller concludes: "There remains a substantial unmet need for more eff...Promising drug fails to improve COPD symptoms
...e among those taking the drug and those taking the placebo as measured by the Chronic Respiratory Questionnaire (CRQ). The questionnaire, which was the primary endpoint, assesses health-related quality of life in patients with functionally limiting chronic lung disease. There were also no differences amon...Recommended doses of ginseng, ginko biloba do not interfere with drug absorption
...he first group received a ginseng supplement and a placebo for ginkgo biloba; the second received ginkgo biloba and a placebo for ginseng; the third received both ginseng and ginkgo biloba supplements; and the fourth received ...Researchers identify new therapy for patients with Crohn's disease
...s, while just 7 percent of patients who received a placebo achieved remission in the same period. Fifty-two percent of patients who received adalimumab achieved an improvement in their clinical symptoms as compared with 34 percent of patients who received a placebo. "This study demonstrates that in the sho...Topical testosterone cream does not increase sexual drive in female cancer survivors
...omly assigned to receive a testosterone cream or a placebo daily for four weeks, then they were switched to t... difference in libido between the testosterone and placebo groups during the first or second 4-week treatment period. Both groups showed increased libido compa...Other highlights in the May 2 JNCI
...n who had a hysterectomy to receive tamoxifen or a placebo for five years. After 11 years of follow-up, 136 women developed breast cancer74 in the placebo group and 62 in the tamoxifen group. Among low-risk women, rates of breast cancer were similar in th...New data shows once a day LAMICTAL XR is effective in patients with partial epilepsy
...tial seizures by 46 percent, while patients taking placebo experienced a reduction of 24 percent over the ent...seizures was 46 percent compared to 24 percent for placebo during the entire treatment phase, 28 percent compared to 16 percent during the escalation phase of ...Studies suggest investigational agent reduces disease activity in MS
...ollowed for a total of at least one year. Though a placebo group was not included in this safety study, brain lesions were reduced by more than 90 percent and the relapse rate was reduced from an average of at least one per patient per year to only a few for the entire group over the year of treatment. Side ...Tip sheet for Annals of Internal Medicine -- May 1, 2007, issue
...CA were assigned to receive either infliximab or a placebo (Article, p. 621). All patients followed a schedul...MR were assigned to receive either infliximab or a placebo (Article, p. 631). At the end of the 22-week study, infliximab had not prevented relapse of symptoms...Commonly used pain medications do not prevent Alzheimer's disease
...ly assigned daily doses of naproxen, celecoxib, or placebo for up to four years, but most participants had received the treatments for less than two years. The study found neither treatment was associated with a reduction in Alzheimer's disease or dementia. "Although our study was conducted to test the...Clinical studies evaluate potential treatments for mouth ulcers
...ree times per day for 60 days, while 12 took three placebo pills per day. Both groups continued to keep diar...th baseline," the authors write. "Patients taking placebo reported no improvement in these variables. Patients taking pentoxifylline also reported more ulcer...Tip sheet Annals of Internal Medicine, April 17, 2007
...uthors selected 20 trials comparing chondroitin to placebo or no treatment and found that chondroitin had little effect on knee or hip pain caused by arthritis. Although few adverse side effects were reported, the authors conclude that chondroitin use should "be discouraged." In an accompanying editoria...New class of HIV drug attacks previously untargeted enzyme
.... One group received the background treatment plus placebo only, and the other three received the background ...ir HIV RNA count, compared to just 45% drop in the placebo group. The number of CD4 cells which give an indication of the immune response were also signifi...Study finds drug helps PTSD nightmares
...ed a nightly dose of prazosin (PRAISE-oh-sin) with placebo over eight weeks. Participants continued to take other prescribed medications over the course of the trial. At the end of the study, veterans randomized to prazosin reported significantly improved sleep quality, reduced trauma nightmares, a better ...Use of hydrocortisone reduces incidence of atrial fibrillation after cardiac surgery
...o receive either 100-mg hydrocortisone or matching placebo the evening of the operative day, then 1 dose ever... likely to have AF than patients randomized to the placebo group (36/120 [30 percent] vs. 58/121 [48 percent]. The relative risk reduction was 37 percent. The ...Experimental flu vaccine appears promising in early tests
...y assigned to receive a single injection of saline placebo (n = 154); 75 g of an rHA0 vaccine containing 15 g of hemagglutinin from influenza A/New Caledonia/20/99(H1N1) and influenza B/Jiangsu/10/03 virus and 45 g of hemagglutinin from influenza A/Wyoming/3/03 (H3N2) virus (n = 153); or 135 g of rHA0 contai...Bypassing eggs, flu vaccine grown in insect cells shows promise
...er dose (135 micrograms), and one-third received a placebo shot that didnt include vaccine. Each of the real shots included vaccine designed to protect against the three strains of flu that had been predicted to be the greatest threat during the 2004-2005 winter, when the study was conducted. As the scient...Study sheds light on medication treatment options for bipolar disorder
...idepressant medication is no more effective than a placebo (sugar pill), according to results published onlin...tidepressants are safe but not more effective than placebo as assessed in a large number of people with bipolar disorder. " Lead author Gary Sachs, M.D., of...Novel anti-oxidant and anti-inflammatory agent shows effectiveness on key endpoints in trial
...nce with the use of succinobucol (AGI-1067) versus placebo on the primary endpoint of a composite of major adverse cardiovascular events, the study did achieve a number of other important predefined endpoints, including a reduction in the composite of hard atherosclerotic clinical endpoints, composed of card...EVEREST data on use of tolvaptan published in JAMA and featured at ACC
...ivotal studies that examined tolvaptan compared to placebo over seven days of inpatient care or discharge, wh...nt yielded significantly greater improvements than placebo based on the primary endpoint (study A: p less than 0.001 and study B: p less than 0.001), which w...