Pezcoller Foundation-AACR International Award for Cancer Research
...pported this model and provided evidence that PI3K plays a critical role in many human cancers. In addition, research from Cantley's laboratory and others has revealed that PI3K also is a significant factor in insulin signaling and in immune cell signaling. As a result, pharmaceutical intervention in th...Angiogenesis factor may help tumors prepare the way for spread to lymph nodes
...th of lymphatic vessels and that lymphangiogenesis plays a key role in tumors' spread to lymph nodes. It had previously been believed that tumors had no functioning lymphatic vessels. The 2001 study focused on VEGF-C, the first factor identified to promote lymphatic vessel growth, and subsequent research h...OHSU scientist helping explain basis of psychotic behavior
...mine is a neurotransmitter found in the brain that plays an important role in the regulation of behavior involved in movement control, motivation and reward, and the dopamine system is thought to be essential to the brain's response to drugs of abuse, especially opiates and psychostimulants. Supersensitivi...2005 Wistar Institute Science Journalism award winner announced
... journalism written in broadly accessible language plays a primary role in communicating progress in biomedicine to the public, which both supports and is the beneficiary of basic biomedical research. For these reasons, journalistic excellence in this area is of the highest importance and deserves to be ho...Stanford gut check shows diversity of intestinal ecosystem
...d by bacteria and archaea. The molecule, 16S rRNA, plays a role in the translation of the genetic code and thus is critical to the organisms. However, small variations in the 16S rRNA gene sequences allow scientists to detect distinct bacteria. For each of the three research subjects, the researchers analy...American Thoracic Society Journal news tips for April 2005 (second issue)
...st cells triggered by the immune response to virus plays a key role in the pathogenesis of virus infections. Many cytokines/chemokines released from activated immune cells not only take part in the process of antiviral immune response, but are also involved in cell damage and development of organ dysfunct...Measuring enzymes at end of cancer pathway predicts outcome of Tarceva, Taxol
...with a cell's sensitivity to Taxol. The CDK enzyme plays a role in cell division, and researchers believe that it functions in part as a monitor of cell cycle activity. Ueno theorizes that if something goes wrong during division - such as if Taxol is interrupting spindle assembly - CDK will become more act...Newborn's first week may be critical period for developing obesity in adulthood
...articularly sensitive. Why that first week of life plays such a critical role in affecting lifelong physiology remains an open question. "Animal studies have shown that overfeeding in the first few days of life lead to long-term obesity, possibly from programming in the developing brain or the endocrine sy...Spice it up or just veg out, either way you may be helping to defend against cancer
...n of epidermal growth factor receptor (EGFR). EGFR plays a crucial role in the growth of ovarian cancer cells. PEITC treatment also inhibited the activation of Akt, which is responsible for protecting cancer cells against apoptosis. The concentrations of PEITC used in the study were at levels that may be a...The Cochrane Library newsletter, 2005, issue 2
... the neurotransmitter L-glutamate. This amino acid plays a key role in normal brain function, especially the formation and reinforcement of memories. In Alzheimer's disease, nerve cells can become overactive to the point where they die. Consequently there is the hope that memantine, which blocks some of L-...Findings about anti-cancer agent could make it more effective
...t to inhibit an enzyme (thymidylate synthase) that plays a major role in the rapid growth and division of cancer cells. But his recent research shows that the agent also acts on another enzyme (topoisomerase) that helps cancer cells replicate. "Inhibiting topoisomerase causes DNA strands to break, which i...New prostate cancer studies look at hormone and protein connection
...tiation, progression and metastases. Beta-catenin plays two important roles inside cells: it functions to glue cells to each other and it promotes cell growth and survival. Beta--catenin can be modified by having sugar molecules attached to its structure. Persad's team will investigate whether modifying...Social connections: Could heartwarming be heart-saving?
...," Loucks said. Studies indicate that inflammation plays a role in causing atherosclerosis. "It seems to allow white blood cells to tether to and become engulfed in the side of the blood vessel wall," Loucks said. "This allows lipids to be deposited in the blood vessel wall more easily, causing atheroscl...MRI study shows hormone leptin alters brains, may ease cravings of people with obesity gene
... Background: Leptin is a protein hormone that plays an important role in regulating body weight, metabolism and reproductive function. Researchers took MRI scans of research subjects' brains prior to beginning leptin replacement treatment, and again at six and 18 months after treatment began. Inv...New fat is needed to clear old fat from the system
...stance. "There's also good evidence that the liver plays a key role in mediating cardiovascular risk through the secretion of multiple proteins associated with inflammation," Semenkovich says. "In these mice we found that when too much fat got into the liver, there was excessive inflammation." With Manu Ch...Innovative study finds way to 'bio-synthesize' an anti-cancer compound
...ant since it helps reveal how a bacterial symbiont plays a role in the biology of a tunicate, which as a representative of the chordates, is not so far away from humans in the tree of life." Eisen says the study "shows yet another way that microorganisms contribute to the biology of animals. Most animals, ...Blocking the Odc gene is effective in preventing cancers
...made. "The insights we now have into the role Odc plays in Myc-induced cancers should contribute to the development of new cancer-preventive therapies for other targets of Myc that are enzymes," said Jonas A. Nilsson, Ph.D., a former postdoctoral fellow at St. Jude who did much of the work on this project...While on trail of dioxin, scientists pinpoint cancer target of green tea
...e aryl hydrocarbon (AH) receptor, which frequently plays a role in turning on genes that are oftentimes harmful. Two years ago the team discovered that AH activity is inhibited by a chemical found in white and green teas, epigallocatechingallate or EGCG, a cousin of flavonoids found in broccoli, cabbage, ...Study concludes primary IGF-1 deficiency is a frequent cause of short stature
...cy typically have low blood levels of IGF-1. IGF-1 plays a principal role in stimulating growth and its deficiency can lead to short stature. Primary IGF-1 deficiency is characterized by abnormally low levels of IGF-1 in the presence of normal or elevated growth hormone levels. Most children with short sta...WINSTON-SALEM Parent's upbringing plays a large role in how they decide to discipline thei...e research also confirmed that how you were raised plays a big role in how you choose to discipline your own children. "Interestingly, only 60 percent of par...