Monoclonal antibody cures West Nile virus-infected mice
...nd his colleagues are excited both by the apparent potency of the antibody and its potential to help them explore new possibilities for treating related viruses that are more prolific causes of human disease and death. "We could give a single dose of this antibody to mice as long as five days after infecti...Is the vaccine industry ailing?
...r cholesterol-lowering agents, hair loss products, potency drugs, or drugs for heart disease or obesity are often $7 billion or more per drug. Furthermore, larger pharmaceutical companies have acquired firms that previously had vaccines as their sole or primary product. So in competing against drugs for a c...Asthma drug fluticasone works as well as other drugs at half the dose
...as impressive as previous studies of fluticasone's potency would predict, according to Adams. "A logical explanation would be for even greater benefits favoring fluticasone to be seen when given at equal daily dose to beclomethasone or budesonide," Adams says. He suggests the "apparent paradox" may be a res...A new understanding of how immune system targets disease
...g blocks, we were able to drastically increase the potency of the T cell response to target epitopes. If confirmed, this discovery will bring immundominance and a major portion of the immune system under our control for the first time."...Options for Parkinson's patients abundant
...and selective MAO-B inhibitors, which increase the potency of dopamine in the brain and serve as antioxidants to clean out neurotoxins resulting from other treatments. But while they have fewer side effects, they provide only modest relief from many symptoms. Support and education are critical when informing...Penn surgeons use completely robotic surgery to treat prostate cancer
...ides patients with the best chance for maintaining potency and continence." Robotic technology offers a number of advantages during surgery. For instance, the robotic "arms" filter even minute tremors of the human hand so to provide steadiness. The robot's camera also provides a three-dimensional, stereoscop...FDA approves room temperature storage of ZLB Behring's Helixate FS
...e based on data from testing to assure the labeled potency (number of recombinant FVIII units contained in a vial) remains within specified limits through the expiration date of the product. The room temperature storage option is expected to be a significant convenience for Helixate FS users. "This is grea...New strides being made in chemoprevention
...s for environmental pollutants. "The unparalleled potency of CDDO-Im in rats highlights the chemopreventive promise of targeting Nrf2 pathways with triterpenoids, and provides a new direction for drug development," said Dr. Yates. "The triterpenoid CDDO-Im appears to be at least 100-fold more potent in t...Killing regulatory T cells boosts effectiveness of cancer vaccine
...is approach holds great promise for augmenting the potency of current cancer vaccination protocols. In their study appearing online on November 23 in advance of print publication in the December issue of the Journal of Clinical Investigation, Johannes Vieweg and colleagues show that the immunotoxin DAB389IL-...Taking an alternative approach to HIV vaccination
...od memory immune response to HIV. In addition, the potency of HIV DNA vaccination was enhanced by co-immunization with an interfering RNA that switched off SOCS1. The authors suggest that this SOCS1 silencing strategy could help enhance therapeutic and prophylactic vaccines against HIV and other pathogens....Estrogen-progestin menopausal hormone therapy and risk of lobular and tubular breast cancer
...g et al.'s results show that women who used medium potency estrogen-progestin combination therapy had a higher risk of developing lobular or tubular breast cancer than of developing ductal cancer, compared with women who did not use hormone therapy. The risk of developing any of the cancers was higher for wo...Evanston Northwestern Healthcare first to use latest robotic surgical system
...mple, better cancer control and a faster return to potency and continence, as documented with da Vinci Prostatectomy. The da Vinci Surgical System consists of an ergonomically designed console at which the surgeon sits; a mobile patient-side cart with four interactive robotic arms; a high-resolution 3D visio...New 'wrinkle' in Botox treatment could lead to lower doses, better safety
...rchers have discovered a novel way to increase the potency of botulinum neurotoxin treatments commonly known as Botox that they say could one day allow patients to receive the injections less frequently while maintaining or even enhancing its cosmetic benefits. By allowing lower doses, the new approach co...Study in Science holds promise for a new approach to drug therapy
...sulted in an eleven-fold increase in the analgesic potency of morphine. Researchers believe it does this by binding to the hotspot, and blocking the G gamma beta subunit's ability to activate phopholipase C, which in turn inhibits pain signals. "Imagine if we could identify 50 small molecules, with each one ...New compound unusually potent at blocking brain cancer growth
...tumor. The compound, known as PI-103, shows unique potency against cancer cell proliferation in studies of mice with grafts of human glioma cells. Gliomas are the most common form of brain cancer, and have proven very difficult to treat. The unique effectiveness of PI-103 stems from its ability to attack two...NIAID study finds higher dose of flu vaccine improves immune response in the elderly
...provide a basis for further evaluation of enhanced potency vaccines in the elderly, says Dr. Keitel....UT Southwestern allergist offers coping strategies for relief from summer allergens
...ctions. Prescription antihistamines can offer more potency and be less sedating than over-the-counter measures, Dr. Khan said. Corticosteroid anti-inflammatory nasal sprays can be used regularly, often once a day, and are generally safe and effective. These are not the same as anabolic steroids that athletes...Research leads to first treatment for drug-resistant HIV
...inhibitors are beneficial for reasons beyond their potency and enduring effectiveness, Ghosh said. "Because they are synthetic, lab-created materials, they are amenable to cost-effective mass production. Keeping costs down greatly increases the accessibility of the drugs to Third World countries where the ...Updated International AIDS Society guidelines recommend new goal of undetectable viral load
...rowing rates of resistance, patients need the full potency of at least two active drugs such as a boosted protease inhibitor (darunavir) and a drug with a new mechanism of action (such as FUZEON) added to a background of an optimised antiretroviral regimen. This strategy is not only recommended by the IAS-US......"Future studies will want to factor such potential potency into designs of screens for additional key cellular proteins that HIV either appropriates as partners, as in the case of p75, or schemes to evade. Quite a few more likely exist. The challenge is to use the right methods to find them." How HIV Infec...