American Thoracic Society Journal news tips for April 2005 (first issue)
...e first was a 6-month regimen in which rifampin (a potent sterilizing agent) was given throughout the time period. Patients began treatment with 2 months of streptomycin, isoniazid, and pyrazinamide, followed by 4 months of isoniazid, and, as stated, rifampin. (Streptomycin has been replaced with ethambut...A possible new phase for rheumatoid arthritis treatment
...ng biological rationale for testing the effects of potent anti-inflammatory therapies during the first few months of clinically apparent disease. "The pathologically distinct nature of the very early phase of clinically apparent rheumatoid arthritis suggests that this phase may represent a therapeutic windo...Bad outcomes related to, but not caused by, misdosing of clotbusters in heart attack patients
...nical complications in heart attack patients given potent drugs to re-open clogged arteries is more likely to be due to individual patient characteristics than to modest misdosing of the drugs, researchers from the Duke Clinical Research Institute (DCRI) have determined. Thus, they said, physicians should n...NIAID begins clinical trial of West Nile virus vaccine
...ellular and antibody immunity offers a potentially potent defense against West Nile virus," says Barney Graham, M.D., Ph.D., chief of the VRC's Clinical Trials Core Laboratory. Adds Dr. Graham, "In our experience in clinical trials, DNA vaccines generally cause few side effects, making them a promising alte...Annals of Internal Medicine, tip sheet, April 19, 2005
... evidence, strong public advocacy groups; and more potent efforts to work with media and with lawmakers and regulators to create a situation where the public good will prevail," they say....Spice it up or just veg out, either way you may be helping to defend against cancer
...ls. "Our results demonstrate that capsaicin is a potent anticancer agent, induces apoptosis in cancer cells and produces no significant damage to normal pancreatic cells, indicating its potential use as a novel chemotherapeutic agent for pancreatic cancer," said Dr. Srivastava. In the second study, abstr...Increasing benefit seen in novel drug that treats Gleevec resistance
...N107 is estimated to be up to 30 to 100 times more potent than Gleevec because it was designed to more efficiently bind to Bcr-Abl, including to mutated forms of the enzyme that can produce Gleevec resistance, Giles says. But the drugs have not been compared head-to-head, so Giles says, "I can't say that AM...Monoclonal antibody cures West Nile virus-infected mice
... antibodies quickly, so when they had identified a potent antibody, scientists at Macrogenics clipped out the genetic material that controls the antibody's targeting and cloned it into a human antibody. The "humanized" antibody should be less likely to induce an adverse human immune system response. A seco...Promising new West Nile therapy cures disease in mice
...monoclonal antibody was several hundred times more potent in cell culture tests than antibodies obtained from people who had recovered from West Nile virus infection....OHSU study finds ginkgo beneficial for MS symptoms
...rbal remedy for a variety of ailments. It contains potent antioxidants called flavoglycosides that have been shown to have neuroprotective effects in animal models of spinal cord injury. It also has terpene-lactones that block a substance known as platelet activitating factor, which is important in regulati...Breast-cancer risk linked to exposure to traffic emissions at menarche, first birth
...AHs, using measurements of benzo[a]pyrene, a known potent mutagen and carcinogen, as a surrogate for total PAH exposure. Cruise emissions, cold engine emissions and intersection emissions were used to estimate total traffic PAH emissions. In addition, meteorological information was used in a geographic di...Northwestern's cancer genetics program ID's gene variant that increases colon cancer risk
.... Now, Dr. Pasche believes the gene is especially potent as a cause for familial colon cancers. The study looked at 208 patients with colorectal cancer and a strong family history of colorectal cancer and found that the number of TGFBR1*6A carriers was twice as high among patients without a mutation in the...UT Southwestern researchers show new drug may help treat certain forms of leukemia
...study shows that PD166326 is nearly 100 times more potent than the current drug imatinib (Gleevec) against cells expressing this enzyme, Dr. Ilaria said. "Our study represents the first published characterization of this novel anti-leukemia drug in animals," Dr. Ilaria said.Gleevec is approved by the Food ...Penn study shows liver receptor key to diet-dependent differences in blood lipid levels
...healthy diet. However, this benefit is lost when a potent drug is added to the system. "The reason is that a...natural ligand rather than a sledgehammer like the potent pharmaceutical drugs that too powerfully activate LXRs throughout the body." The hope is that these ...Anti-depressant use linked to increased GI bleeding
...orthwestern University Medical School. "This is a potent example of the need for doctors to be particularly conscientious about potential side effects when prescribing multiple medications for their patients."...Newly discovered 'branding' process helps immune system cells pick their fights
...r, these compounds generate peroynitrate, a highly potent chemical that modifies many proteins. Unanue's group showed that this chemical modifies the peptides presented by antigen-presenting cells in several distinct ways. For example, they attach a nitrate group to the amino acid tyrosine in the peptides,...As morphine turns 200, drug that blocks its side effects reveals new secrets
...ctive alternative to morphine, came up with a more potent narcotic, diacetylmorphine, in 1874. Heinrich Dreser, a chemist at Bayer Laboratories developed and tested Wright's new semi-synthetic drug on animals, humans, and most notably himself. Finding that it was a powerful painkiller and appeared effect...Red delicious, Northern Spy apples have most antioxidants, chemists find
... Alzheimers disease. In rats, quercetin another potent antioxidant abundant in apples appears to protect brain cells against oxidative stress, a tissuedamaging process associated with Alzheimers and other neurodegenerative disorders. This study was published in the December 1, 2004, issue of the Journa...Arthur Frommer tells America where to stop when they need to go
...incontinence, urgency and frequency. Enablex is a potent muscarinic receptor antagonist that helps reduce incontinence episodes, increases the amount of urine that the bladder can hold, and decreases the pressure or urgency associated with the urge to urinate. It offers a unique M3 profile with sustained e......rely on testosterone to grow. "Hormone balance has potent effects on the prostate and prostate cancer," Dr. Terris says. "Most prostate cancer researchers have accepted the suggestion that higher estrogen and lower testosterone suppress prostate cancer growth with the exception of those cancers that are not...