In a crisis, creating DNA vaccine could help save lives, slow spread of 'bird flu'
...za outbreak occurs. A DNA-based vaccine could be a potent weapon against this emerging threat, particularly if enough conventional vaccine isn't available, according to Peter Dunnill, DSc., and his colleagues at University College London. However, they caution that any DNA vaccine should only be used as nee...Clinical trials with immunotherapy for breast and colorectal cancer
...with breast or colorectal cancer. The study uses a potent immune-enhancing gene delivered directly into the ...r cells directly in the patient's tumor. IL12 is a potent immune enhancing protein that is not normally produced by cancer cells. When the cancer cells produc......ins, who recently discovered that sulforaphane had potent antibiotic activity against H. pylori in test tubes. When broccoli-sprout eaters stopped their daily dose at the end of the study, gastritis and infection rates rose to pretreatment levels. "H. pylori infection is especially prevalent in places wit...New strides being made in chemoprevention
...enoid CDDO-Im appears to be at least 100-fold more potent in this model than other drugs targeting Nrf2 that are currently in clinical development." NSAIDs and COXIBs: The Burden of Proof (Abstract 3480) The effectiveness of non-aspirin non-steroidal anti-inflammatory drugs (NA-NSAIDs), the related cycl...Focus on lung cancer: How to prevent and treat it
...ells. Newer molecularly targeted drugs, which are potent anti-cancer drugs in mice, are struggling in lung cancer prevention trials due to concerns with drug-associated side effects. However, as targeted agents with fewer side effects and preventive efficacy enter clinical trials, researchers will soon be...Study broadens understanding of enzymes linked to tumor promoting molecule
...phK1 and SphK2, a family of enzymes that forms the potent lipid mediator sphingosine-1-phosphate (S1P), have opposing roles in the regulation of ceramide biosynthesis. S1P is a molecule that has been shown to promote tumor cell growth and inhibit cell death. They found that the different effects of SphK1 a...Clinical decision system helps reduce inappropriate antimicrobial prescribing
...t ameliorate the fitness costs of resistance. More potent interventions that sustain greater improvements in antimicrobial use may be needed to adequately control antimicrobial resistance," the researchers conclude....Red kiwi poised to make a healthy debut
... anthocyanins, bright red pigments that are highly potent antioxidants, which are thought to provide protection against heart disease and cancer. Kiwifruit already have the reputation of being among the most nutrient dense of all popular fruit and they are also high in antioxidant activity. Now, kiwis com...Bird flu virus triggers worse inflammation in human lung cells than human flu viruses
... H1N1. Their results show that H5N1 is a much more potent inducer of pro-inflammatory proteins than H1N1. Twenty-four hours after infection with H5N1/04, the levels of the chemokine IP-10 in bronchial epithelial cells reach 2200 pg/ml, whereas in cells infected with H1N1 they only reach 200pg/ml. In H5N1/97...New RSV treatment for at-risk infants under study
...at respiratory synctial virus, or RSV, to the more potent MEDI-524, says Dr. Jatinder Bhatia, chief of the M...hey will get monthly doses of MEDI-493 or the more potent MEDI-524, or Numax TM , Ms. Holloway says. Parents with babies born at other hospitals who qualify f...Gene therapy potential for treatment of pancreatic cancer
...l experiments. This type of gene therapy "may be a potent strategy to treat many malignant tumours, including pancreatic cancer, and represents a promising therapeutic option for malignancy with a poor prognosis," conclude the authors....Compound from marine bacteria shows potential as multiple myeloma therapy
...ttom sediments appears in laboratory tests to be a potent killer of drug-resistant multiple myeloma cells, and potentially with less toxicity than current treatments, report Dana-Farber Cancer Institute researchers in the November issue of Cancer Cell. The experimental compound, NPI-0052, has been found to ...Drug compound restores youth to aging arterial cells in elderly hypertensives, Hopkins study shows
...at the cellular effects of aging caused by AGE are potent targets for new therapies. In the Hopkins study, 13 elderly men and women with systolic hypertension took either daily doses of alagebrium (210 milligrams) for eight weeks or a look-alike pill (placebo), containing no active drug. AGE and collagen l...New vaccine platform may fight infections with causes from influenza to bioterrorism
...studies, the researchers discovered a particularly potent fragment of pneumocystis, the kexin molecule, which when isolated yielded greater antibody response than pneumocystis as a whole. In perhaps the most significant experiments the researchers conducted, mice depleted of CD4+ T cells received the combi...Major ovarian cancer clinical study announced at Yale using combination drug therapy
...s the demonstration in pre-clinical studies of the potent ability of phenoxodiol to reverse chemo-resistance in human ovarian cancer cells to docetaxel, through the ablation of anti-apoptotic proteins in the tumor cells. The second is the encouragingly high tumor response rate observed in a current clinica...Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease
...heir tests also revealed that mice infected with a potent bacterium survived after treatment with CEP-701. Additional authors include Peter A. Calabresi, Erin McCadden, Bao Nguyen, David Kardian, Tianhong Wang, Claudio Mosse and Drew M. Pardoll from Johns Hopkins....New pain research: Routine Tylenol for nursing home residents with dementia increases activity
... that does not carry the side-effect risks of more potent opioid analgesics. Under certain circumstances, prophylactic treatment of pain in elderly persons with dementia therefore appears safe and effective in increasing active engagement with the environment."...Scientists directly view immune cells interacting to avert autoimmunity
...aid. Immunologists have long sought to harness the potent immunosuppressive properties of the regulatory T cells to treat autoimmune diseases and organ transplant rejection. By pinpointing where and how regulatory T cells work in vivo in mouse models, the researchers hope to better adapt the regulatory T ce...Access to existing medical treatments could save more lives than spending to improve the treatments
...ore strokes than were prevented by developing more potent and more expensive antiplatelet drugs, Woolf said....d have been prevented by sticking with older, less potent statins but adopting simple reminder systems such as post-it notes on the front of charts that would......riments with AMN107 show it is up to 50 times more potent because it binds more efficiently to the enzyme than does Gleevec. In the phase I clinical trial being reported, 119 patients who were resistant to Gleevec were given AMN107, and in some cases the dose was increased up to twelve fold. The researchers...