New studies identify advances in treatment of chronic myeloid leukemia
...ol the growth of cells. The drug is 325-fold more potent than imatinib in cells transduced with normal BCR-...the development of CML. It is 10- to 50-fold more potent than imatinib against BCR-ABL-expressing cell lines, including most imatinib-resistant BCR-ABL mutan...Mayo Clinic reports tamoxifen benefit for breast-cancer patients tied to inherited gene
...a metabolite that is nearly one hundred times more potent than tamoxifen," says Dr. Goetz. "Our study demonstrates that women who inherit a genetic change in the CYP2D6 gene that lowers the level of this enzyme appear to be at higher risk of relapse when treated with five years of tamoxifen. "In addition t...Ancient Chinese remedy shows potential in preventing breast cancer
... said. "The present data indicate that it may be a potent cancer-chemoprevention agent. "Additional studies are needed to investigate whether the breast cancer prevention property of artemisinin can be generalized to other types of cancer."...Resolved to lose weight? Social cues encourage overeating: University of Toronto study
...riety and the food intake of fellow eaters are all potent influences on individual consumption. Norms may also become elevated depending on the social context in which they function, such as the case of the individual who, wishing to avoid appearing overindulgent, may refuse second helpings at a formal meal...Polio vaccination strategies assessed as eradication nears
...the digestive tract by IPV was believed to be less potent that that of OPV. Therefore, although those immuni...med using only one dose of a vaccine that was less potent that the currently used version. Konstantin Chumakov, PhD, and colleagues at the Food and Drug Admin...Oral contraceptive pill may prevent more than pregnancy
...4 and 53% of women age 20-24 years. By providing a potent synthetic estrogen (ethinyl estradiol) and a potent synthetic progesterone (for example norethindrone), highly effective contraception is achieved by d...Loss of caspase-8 makes neuroblastoma more aggressive
...showed that neuroblastoma metastasis is especially potent in the absence of caspase-8." To investigate the impact of the loss of caspase-8 and/or integrins on neuroblastoma metastasis, the team tested the ability of tumor cells removed from patients for their ability to metastasize in laboratory embryo mod...Flu not the only germ threat this time of year
...f the disease. And though "regular" flu is still a potent threat, expected to kill more than 35,000 people in the United States annually, your sick neighbor or colleague who probably doesn't have the flu is a sniffling, sneezing, wheezing, whining reminder that there are other germ threats. Infectious disea...Study sets new gold standard for initial antiretroviral treatment of HIV infection
...ricitabine, plus efavirenz, is likely to be highly potent with minimal side effects or long-term toxicity," says the study's lead author, Joel Gallant, M.D., M.P.H., associate professor and associate director of the AIDS Service at The Johns Hopkins University School of Medicine. Gallant notes that this re...Mice studies illustrate potential of chimp/human antibodies to protect against smallpox
...anzees, the study researchers identified a pair of potent antibodies that target and neutralize the B5 prote...virus and likely smallpox and are potentially more potent and more specific than the treatment we currently have available," says Dr. Purcell. The hybrid anti...Compounds in licorice root may help fight tooth decay
... contains at least two compounds that appear to be potent inhibitors of Streptococcus mutans , a major cause of dental caries. Their study is scheduled to appear in the Feb. 24 print version of the Journal of Natural Products , a monthly peer-reviewed joint publication of the American Chemical Society and...Treatment of Down syndrome in mice restores nerve growth in cerebellum
...y lower response to increasing concentrations of a potent form of Shh called ShhNp. That is, increasing concentrations of ShhNp triggered increasing rates of mitosis. Despite their lower response, trisomic cells did show a dose response with increasing ShhNp concentrations. "The fact that trisomic GCP res...Studies confirm effectiveness of fentanyl lozenges for 'breakthrough' cancer pain
...arcotic pain medications. It is exponentially more potent than morphine. Current treatment for breakthrough pain typically involves so-called "rescue medication" -- a supplemental dose of a patient's current pain medication. The review findings showed that fentanyl is more effective. Forty-eight study pati...JCI table of contents, January 26, 2006
... down into a variety of smaller peptides that have potent action in the body, and if lost, can cause obesity. However, it is unclear whether the POMC peptides from the central nervous system (hypothalamus) or the pituitary are responsible for obesity. To find out, Malcolm J. Low and colleagues at the Oregon...Increased role for PET imaging could improve cancer care
...m becoming resistant to chemotherapy before a more potent treatment can be tried. Alternative treatment options would be pursued for these patients. Juweid also suggests that another way to capitalize on PET's ability to detect tumor response early will be using PET images to establish end points in trials...Vitamin D inhibits progression of some prostate cancers
... in the study is 1,25-hydroxylvitamin D3, the most potent and active form of vitamin D in the human body. But Lee and other scientists at the Medical Center's James P. Wilmot Cancer Center do not advise taking large amounts of vitamin D without medical supervision. "This high dose has some side effects, inc...Sydney scientists discover and license breakthrough anti-inflammatory treatment
...ade a therapeutic antibody against one of the most potent inflammatory agents in the body and used it to cure arthritis in mice. The next step is to translate the highly effective outcome we see in mice to human patients. If we can do this, we will have a revolutionary new treatment for a number of importa...Study sets treatment standard for elderly with colon cancer
One of the newest and most potent chemotherapies for colon cancer is as safe and effective for the elderly as it is for younger patients, based on a University of North Carolina at Chapel Hill-led data review. The analysis focused on nearly 4,000 colon cancer patients who had been e...New compound protects against liver cancer
...on in humans. "If this compound can produce such a potent and dramatic reduction in the number of pre-cancerous growths, it should have an equally dramatic impact on the development of actual cancers. This study suggests that we may be on the right track in terms of chemoprevention. It may open the door for...Great (taste) expectations: Study shows brain anticipates taste, shifts gears
... to mitigate an unpleasant experience. "There is a potent impact to expectancy," says Nitschke, who, with his colleagues, exposed 43 undergraduate subjects to potions of quinine, sugar water or distilled water while undergoing magnetic resonance imaging (MRI). The subjects, Nitschke explains, were asked bef...