New insights into the link between rheumatoid arthritis and cancer
... indicating a possible lymphoma-protective role of potent anti-inflammatory drugs. Of all the medical treatments assessed, researchers observed increased lymphoma risk associated only with azathioprine (AZA), which is not regarded as a traditional DMARD for RA and rarely used in current treatment. ...Einstein scientists discover cause and possible treatments for hereditary movement disorder
...alcium-activated potassium channels proved to be a potent therapeutic target, since chronically activating them with EBIO definitely improved the motor performance of these ataxic mice," says Dr. Khodakhah, who was senior author of the study. "We don't really have effective treatments for these types of ata...Update on tuberculosis -- 2005
...oxifloxacin, a drug with a long half-life that has potent bactericidal and sterilizing powers, has produced a stable cure, without relapse, in a mouse model of tuberculosis....New study shows benefit of early therapy in HIV-infected infants
...rs concluded that "children who started their most potent ART between 5 months and 5 years of age were almost 60 percent less likely to attain a 20 percent increase in their CD4 cell count z-score at any time, compared to children who started treatment before 5 months." However, the authors did not find an ...Drug that switches on genes improves myelodysplastic syndrome treatment
A potent member of a new class of drugs increases survival in some patients with myelodysplastic syndrome (MDS), and may become the new standard of therapy for this group of pre-cancer disorders, say researchers at The University of Texas M. D. Anderson Cance...Medication reduces risk of adverse events for patients with acute coronary syndromes undergoing PCI
...600 mg of clopidogrel eliminates the need for more potent antiplatelet therapies in patients with ACS undergoing PCI. Adnan Kastrati, M.D., of the Deutsches Herzzentrum, Munich, Germany and colleagues with the ISAR-REACT 2 Trial assessed whether abciximab is a useful therapy in patients with nonST-segment e...Post-stent maintenance therapies questioned
...her risk patients with ACS may benefit from a more potent antithrombotic regimen. The ISAR-REACT 2 trial evaluated for the first time the value of abciximab in patients with ACS undergoing PCI after pretreatment with 600 mg of clopidogrel. "No specifically designed randomized studies have previously been ...Cedars-Sinai researchers discover treatment for deadly brain tumors and infections
...n's immune privilege and was able to elicit a very potent anti-glioma immune response. The discovery on the mechanisms to overcome the immune privilege in the brain will open up very exciting therapeutic opportunities to treat primary and metastatic brain cancers and deadly brain infections. The high levels...UC Berkeley study finds in utero arsenic exposure tied to lung disease and cancer in adults
...semi-metal, the element arsenic is one of the most potent cancer-causing agents known. Skin, bladder and lung cancer rates are substantially higher in regions where the tasteless, colorless substance occurs in drinking water. A recent study by Smith showed that adults exposed to arsenic can also develop dec...Sweet chemistry: Symposium explores sugar alternatives, science of taste
...rtame that is 10,000 times sweeter than sugar. The potent sweetener can reduce the amount of high-fructose c...than sugar, is not only safe but may prove to be a potent weapon against obesity and type 2 diabetes. ( AGFD 168 , Thursday, March 30, 10:28 a.m.)...Fighting inflammation with targeted liposomal therapy
...essively damage tissue, and joints. Recognized as potent inflammation inhibitors, corticosteroids work to control the expression of cytokines, adhesion molecules and the growth of endothelial cells. The potential of these drugs, however, has been restricted by their considerable toxicity and short half-li...HealthGrades patient safety study shows increase in hospital incidents, gaps among state, hospitals
...whelming bacterial bloodstream infection requiring potent antibiotics and other treatment resulting in a longer hospital stay and possibly death. Both of these are areas of focus for the most progressive hospitals, who have developed successful ways of minimizing or eliminating deaths from these incidents."...Fat cells around coronary arteries may play a role in heart disease
...known to be highly active metabolically, releasing potent pro-inflammatory proteins and hormones that regulate inflammation, blood pressure, insulin activity, and other biological processes. Where fat cells are located has a major influence on their impact, as seen in the fact that visceral fat surrounding...Capsaicin shows promise in inhibiting growth of pancreatic cancer
...ells. "Our results demonstrate that capsaicin is a potent anticancer agent, induces apoptosis in cancer cells and produces no significant damage to normal pancreatic cells, indicating its potential use as a novel agent for the prevention and treatment of pancreatic cancer," said Dr. Srivastava. Pancreatic ...New 'wrinkle' in Botox treatment could lead to lower doses, better safety
...search Institute in La Jolla, Calif. Smaller, more potent doses may even lead to lower prices for the popular wrinkle-remover, the researchers say. Their study is published in the March 29 issue of the weekly Journal of the American Chemical Society . Although popular for removing wrinkles, Botox is als...Nano-particles effective in killing cancer with one-two punch of chemotherapeutics
...e that biodegradable nano-particles containing two potent cancer-fighting drugs are effective in killing human breast tumors. The unique properties of the hollow shell nano-particles, known as polymersomes, allow them to deliver two distinct drugs, paclitaxel, the leading cancer drug known by brand names s...Taller people more likely to develop atrial fibrillation
...American College of Cardiology. "Tall stature is a potent risk for the development of atrial fibrillation and is independent of other clinical risk factors. Indeed, the male predominance of atrial fibrillation appears to be explained by the difference in height between men and women," said Jonathan J. Langb...Gene variations linked to brain aneurysms
...ions of a gene responsible for the production of a potent chemical involved in inflammation among 91 people with an unruptured brain aneurysm and 2720 healthy people matched for age and race. Interleukin-6 or IL-6 for short is involved in the inflammatory processes of coronary artery disease and has been i...New drug could reduce tissue damage after heart attack
... collaborative study has now rationally designed a potent small molecule inhibitor of CRP. The new compound, bis(phosphocholine)-hexane, is bound by CRP, inhibits all CRP functions in the test tube, and blocks the tissue damaging effect of CRP in an experimental heart attack model. Professor Mark Pepys, of ......m is to identify the drug design that has the most potent anti-tumor efficacy," he said. Debinski will also explore how cancer cells' lack of oxygen affects the treatment. Hypoxia, a lack of oxygen in tissues that causes cell stress, is a characteristic common to all solid tumors and is known to interfere ...