Could a popular HIV drug benefit hepatitis B patients?
...e. "We have high hopes that Tenofovir will be more potent than the current drug regimen for hepatitis B patients," Di Bisceglie says. Hepatitis B is a disease passed down from mother to infant during pregnancy and has reached epidemic levels in China, Vietnam and sub-Saharan Africa. "It is a terrible diseas...Online calculator and chemotherapy order systems reduce medication errors in children
...t even greater risk because the general dangers of potent chemicals are compounded by the dosing challenges. "Our findings reveal that using a Web-based calculator makes it less likely to order and give a child the wrong dose or commit other errors, such as omitting patient information, weight parameters o...M. D. Anderson: Setting the benchmark in brain tumor treatment
...ed on doxorubicin, a widely used drug that is very potent and effective in a lot of solid tumors, but which always has been pumped out of the brain faster than it could accumulate in tumor tissue," Priebe says. "This new drug may represent a treatment not only for tumors that originate in the brain, but als...New compound unusually potent at blocking brain cancer growth
...cientists have identified what is perhaps the most potent drug candidate yet against a highly lethal kind of brain tumor. The compound, known as PI-103, shows unique potency against cancer cell proliferation in studies of mice with grafts of human glioma cells. Gliomas are the most common form of brain canc...Marijuana-derived drug suppresses bladder pain in animal models
ATLANTA, May 21 IP 751, a potent synthetic analog of a metabolite of THC--the princ...f the American Urological Association. IP 751 is a potent anti-inflammatory and a powerful analgesic, although the mechanisms by which it works are unknown. H...Exploring the potential of cholesterol-lowering drugs for patients with systemic sclerosis
...e the effectiveness of one of the most popular and potent cholesterol-lowering drugs atorvastatin, marketed under the brand name Lipitor for increasing blood flow and improving the symptoms of SSc. The study focused on 14 women, between ages 36 and 75, with a confirmed diagnosis of SSc. Disease duration ...Penn researchers question change in 'gold standard' for assessing heart failure treatment
... all the things we do, the maximal VO2 is the most potent predictor. We decided to look at what happened to these patients, both men and women, after they had the VO2 stress test done, to see how many of them went on to receive a heart transplant and how many did not survive," explains Lee Goldberg, MD, MPH...Clinical trial confirms novel EGFR antibody targets tumors but not normal tissues
...s Fiore, President and CEO of LSP. "This mAb has a potent anti-tumor activity, with no targeting of normal tissues, in xenograft models, and now this clinical study has validated its target-specificity and safety in humans." The clinical trial confirmed the excellent targeting of ch806 to cancers including ...Transporter is possible target for safer pain medicine
...id peptide levels increase during childbirth. Many potent pain killers, such as morphine and codeine, override this natural pain control system by directly activating opioid peptide receptors. While pain control is effective, it comes at a price: potential addiction, immune suppression and constipation. Now...World's first approval of new HIV drug TMC114 provides potent new treatment option with FUZEON
...nhibitor (PI), provides the opportunity to build a potent new treatment combination with the fusion inhibitor FUZEON (enfuvirtide) that can successfully combat the HIV virus in treatment resistant patients. Data have shown that up to two-thirds of patients with extensive prior exposure to anti-HIV drugs ach...Enzyme inhibitor may provide strategy to treat some GI disorders, Jefferson researchers find
...tudies demonstrated that Rho kinase inhibitors are potent smooth muscle inhibitors, causing direct smooth muscle relaxation. "The next step in the work," says Dr. Rattan, "would be to try these kinds of tests in the hypotensive state of the IAS in animal models first, and then hopefully in humans with so...Saving antiretroviral treatment in long-term HIV-positive patients
...ly active antiretroviral therapy (HAART), in which potent anti-HIV drugs are used in combination, has led to a significant decline in mortality and morbidity of people infected with HIV. However, a substantial amount of patients (about 50%) have virus, which has acquired resistance to antiretroviral drugs f...Stanford snake venom study shows that certain cells may eliminate poison
... to respond to many snake venoms by secreting some potent biologically active mediators, they hypothesized that mast cells might also act to degrade sarafotoxins and reduce the toxicity of the Israeli mole viper venom. Galli and Metz first did experiments in vitro using isolated sarafotoxin 6b with mast c...Malignant melanoma cells secrete protein required for embryo formation
...al Nature Medicine. The researchers identified the potent and highly unstable embryonic growth factor by injecting aggressive melanoma cells into developing zebrafish embryos, which were used as "biosensors" for tumor cell-derived signals, and were consequently able to induce ectopic (abnormal) embryonic sk...Deadly latex evading lax food labelling laws
... 'For a few people, natural rubber latex is a very potent allergen and for these individuals, there is no safe level of exposure,' says LASG representative Graham Lowe. 'We would welcome an approach to the EU to consider this evidence and the issue of labelling,' he said. Lowe added that latex transfer to f...Imaging study may help point toward more effective smoking cessation treatments
...accines for smoking cessation need to be extremely potent to compete with nicotine, which binds so readily to these receptors." The study is published in the August 2006 issue of the Archives of General Psychiatry. "This study illustrates the powerfully addictive impact of even small amounts of nicotin...Mayo Clinic: New recommendations for use of bisphosphonates in treatment of multiple myeloma
...nts who are starting therapy, over the newer, more potent drug zoledronic acid, which is more frequently associated with serious damage to jaw bones. Also in the interest of safety, the team recommended that patients without active disease stop bisphosphonate therapy after two years, and patients with acti...Clinical trial evaluates first-line approaches for treating HIV
... lopinavir/ritonavir is considered one of the most potent drugs that we have available for HIV treatment at this time. It may be that the lopinavir/ritonavir regimen, which was dosed twice daily using the soft gel capsule form, was less convenient or less well tolerated by patients. We will continue to eval...Panel updates guidelines for treatment of adult HIV infection
...ional agents in 5 drug classes have been approved; potent combination therapy has become a worldwide standard of care; morbidity and mortality in the developed world have been substantially reduced, and major antiretroviral rollouts have been initiated in the developing world. Balanced against this progress...New medication appears effective in helping smokers kick the habit
...re opening up new vistas for safe, efficacious and potent treatments for nicotine dependence," he writes. "Molecular genetic studies also are investigating how to identify those individuals vulnerable to becoming nicotine dependent and, once they are dependent, the treatments that might work best for them....