Molecular structure reveals how botulinum toxin attaches to nerve cells
...to botulinum neurotoxins, which are among the most potent toxins known. These neurotoxins are produced by Clostridium botulinum, a bacterium found in soil and food. In the body, the toxins bind to and enter neurons, interfering with nerve transmission and disrupting the communication between the nerve and m...Epidemic of multi-drug-resistant tuberculosis may be larger than previously thought
... is defined as resistance to at least the two most potent anti-TB drugs, isoniazid and rifampicin. In 1994, the Global Project on Anti-Tuberculosis Drug Resistance Surveillance was set up to determine the prevalence, patterns, and trends of anti-TB drug resistance around the world. Mario Raviglione (World...Darunavir with FUZEON provides HIV patients a better chance to reach undetectable viral load
...means that patients will soon have access to a new potent anti-viral combination....Hybrid molecule causes cancer cells to self-destruct
...oblem, scientists have tried to make butyrate more potent by modifying it or joining it to other compounds. Usually, the results have been disappointing because the molecular partner added to butyrate to improve delivery to the cancer cells often produced unsafe side effects. In some of the less successfu...New angiogenesis inhibitor has promise for treating deadly brain tumor
...r investigation. An oral medication, AZD2171 is a potent inhibitor of the three primary receptors for the powerful angiogenesis factor VEGF, known be present on glioblastoma blood vessels. Manufactured by AstraZeneca, AZD2171 is currently available only to participants in clinical trials. The MGH trial...UIC receives grant to find new drugs for bipolar disorder
...wski said. His group has already identified some potent GSK-3 inhibitors by screening analogs of staurosporine, a natural product that is able to block a number of protein kinases. Some of these compounds are able to protect nerve cells in the test-tube and block mania in animals, he said. "Other member...Bioterrorism alerts induce anxiety and may pose health risk, Einstein study finds
...n) randomly received one of two messages: either a potent bioterrorism message portraying a graphic account ...public health challenges. Those receiving the more potent message became the "experimental" group, while those receiving the more neutral message were conside...Oral wounds heal slower in women, older adults, study finds
...sor at UIC and lead author of the study. "It's a potent anti-inflammatory hormone that is abundant in saliva," he said. Women are generally more prone to inflammatory diseases, such as rheumatoid arthritis, Engeland said. In skin, women's wounds heal faster than men's in part because inflammation causes...Honeydew honeys are better antioxidants than nectar honeys
...dea about which honeys are likely to have the most potent antioxidant properties, says Prez....JDRF awards Emory $2.5 million to develop islet transplant technology
...e porcine islets for transplant; circumventing the potent rejection barriers to acceptance of the xenograft; and understanding and minimizing the risk of transmission of porcine pathogens to human transplant recipients and the general population. In 2002, the JDRF awarded Emory scientists $4.1 million to ...Steroid use fails to boost pregnancy rates in infertility treatments
... The steroid hormones called glucocorticoids have potent effects on the bodys inflammatory and immune responses, so many fertility specialists prescribe them in hopes of making the lining of the uterus more receptive to embryo implantation. But lead review author Carolien Boomsma says that routine practice...Chromium 6: A killer compound with an improbable trigger
...ry different effect. Cellular vitamin C acted as a potent toxic amplifier, sparking significantly more chromosomal breaks and cellular mutations. "When we increased the concentration of vitamin C inside cells, we saw progressively more mutations and DNA breaks, showing how seemingly innocuous amounts of c...Crestor effective at halting early atherosclerosis
...sing ultrasound technology has found that the most potent cholesterol-lowering drug is also effective at halting early changes in the blood vessels that can lead to atherosclerosis. "Rosuvastatin arrested the progression of thickened carotid arteries compared to a placebo," said John R. Crouse, M.D., lead...Blueberries contain chemical that may help prevent colon cancer
... of Agriculture. The compound, pterostilbene, is a potent antioxidant that could be developed into a pill with the potential for fewer side effects than some commercial drugs that are currently used to prevent the disease. Colon cancer is considered the second leading cause of cancer death in the United Sta...Cancer-fighting foods, supplements explored in day-long symposium, March 25
... of Agriculture. The compound, pterostilbene, is a potent antioxidant that could be developed into a pill wi...h-fiber items shows promise in animal studies as a potent weapon for preventing prostate cancer. The compound, inositol hexaphosphate (IP6), was fed to animal...Northwestern chemists develop new method for synthesizing anti-cancer flavonoids
... all the characteristics you want -- it may not be potent enough, for example -- but with chemistry you can go in and modify that structure, imbuing the molecule with more desirable traits, such as binding more effectively to a protein of interest or being less toxic to normal cells." The biosynthesis of ...Bypassing eggs, flu vaccine grown in insect cells shows promise
...wing vaccine in eggs, a danger when working with a potent bird-flu strain. The technology would also help make it possible to boost the dose that patients receive, by increasing the nations capacity to churn out vaccine. Thats especially crucial in the fight against bird flu, as Treanor and other scientis...New class of HIV drug attacks previously untargeted enzyme
... Raltegravir also proved safe, well tolerated and potent in most of the patients. In related studies of raltegravir*, 60% of the patients taking the drug reduced their HIV RNA loads to below 50 copies per ml the lowest recordable value. Only 30% of patients in the placebo group achieved this The autho...Research could lead to treatment for Alzheimer's disease
...allowed us to build a molecule that is both highly potent and highly selective, meaning it does not affect o...ely, all of our early designed compounds that were potent against memapsin 2 also inhibited memapsin 1," he said. "Selective inhibition of memapsin 2, or buil......lly valuable in several ways, from their brisk and potent antimalarial activity to their lack of resistance and cross-resistance with other antimalarial agents," Shapiro said. The Johns Hopkins trioxanes mimic artemisinin, the active agent in a Chinese herbal drug used to treat malaria and other fevers fo...