2005 Potamkin Prize goes to neurologists for research in early detection of Alzheimer's disease
...the disease. Current efforts focus on detection of preclinical Alzheimer's, prior to the onset of symptoms, using imaging modalities and assays of biological fluids." John H. Growdon, MD, of Harvard University, who chaired the committee that selected the Prize recipients, said, "Dr. Morris' research has sharpene...Measuring enzymes at end of cancer pathway predicts outcome of Tarceva, Taxol
...ues of human xenograft model. "This provides solid preclinical evidence that we can use toward development of a novel device that can measure CDK activity in human tissue within several hours," Ueno says. He adds that a clinical trial is currently under way that tests CDK activity both before and after patients ...UQ develops West Nile virus treatment
...ciate Professor Alex Khromykh, which is undergoing preclinical trials. A West Nile diagnostic reagent also developed by Dr Hall has been licensed for sale in the U.S. and will be used to track the spread of the disease in animals and birds in North America. Dr Hall said it was very satisfying to see his researc...Northwestern Memorial participates in trial to test effectiveness of drug to treat endometriosis
... begins. "ERB-041 is a 'key' for ERβ, and in preclinical models can cause endometriosis lesion regression," explains Dr. Shulman. "Because ERB-041 is highly selective for ERβ, it does not affect reproductive organs like nonselective estrogens, such as those found in oral contraceptives." ERB-041 ha...Researchers study natural products that may prevent certain cancers
...ng potential side effects. If our data from these preclinical studies are positive, they will create the basis for human patient studies on the safety and effectiveness of these agents."...New technique appears to stop abnormal blood vessel growth
...almology & Visual Science."We have a promising new preclinical approach to treat conditions that involve blood vessel formation," says Dr. Ambati. These include corneal injury, the blinding wet form of macular degeneration, diabetic retinopathy and tumors, which need blood and oxygen to survive.Other angiogenesi...Cancer killing virus shows early promise against colorectal cancer
...ffective against chemotherapy-resistant cancers in preclinical studies. The specific strain of virus investigated...to use multiple doses of the virus since there are preclinical data to indicate that herpes oncolytic viruses work best when administered in multiple doses. Commen...Promising new TB drug enters clinical trial
...liance), NIAID contributed to the drug candidate's preclinical safety and efficacy testing in animal models. Now,...logy transfer assistance and project management of preclinical testing of the compound A contract to Ian Orme, Ph.D., of Colorado State University that confirmed ...A step forward in stem cell research
...sors derived from HESCs will provide the basis for preclinical mouse studies to assess the safety of these cells. The investigators have already taken the next step in this research and are testing the therapeutic potential of embryonic stem cell-derived muscle cells in animal models of muscle disorders....The promise of a tetracycline antibiotic for treating osteoarthritis
...ck and promotes smooth movement On the strength of preclinical evidence, a team of rheumatologists affiliated with six clinical research centers across the United States conducted the first long-term clinical trial to determine the benefits of doxycycline in the treatment of OA--particularly, OA of the knee. Th...Emory researchers offer new approach for testing potential HIV vaccines in animals
.... By using lower doses and challenging repeatedly, preclinical trials would be more similar to epidemiological ph... in humans. This allows us to optimize vaccines in preclinical trials with respect to what really matters epidemiologically." Using a standard statistical power a...GroPep licenses technology to TGR BioSciences
...ollaborators have previously generated significant preclinical and clinical data, including a successful Phase 1b trial conducted at the Peter MacCallum Cancer Centre in Melbourne, indicating the safety and potential for WGFE to treat this condition. TGR has committed to initiate further clinical development in ...Early warning signs of Alzheimer's show up across cognitive areas years before official diagnosis
...general deterioration and tends to follow a stable preclinical stage with a sharp drop in function. The findings...tringent criteria had records on 1,207 people with preclinical Alzheimer's (they later developed the disease) and 9,097 controls who stayed healthy. Neuropsychol...Prevent prostate cancer with antioxidants? Gene pathway may reveal more clues
... with defective Nkx3.1 provide a valuable tool for preclinical studies to test whether antioxidants might be useful for prostate cancer prevention," Abate-Shen says and continuing studies will test antioxidants or other agents on the altered mice. Prostate cancer is the most commonly diagnosed cancer in men and...National funding goes to Johns Hopkins to advance research on stem cell therapies for heart attack
...linical trials. The second project continues with preclinical animal and laboratory research, required by the Food and Drug Administration before new therapies can be approved for initial testing. The laboratory research group will be led by Marbn, whose team will study the potential of using a patient's own ca...Other highlights in the October 5 JNCI
...remarkable but caution that it requires additional preclinical study of potential barriers to clinical use in patients. Contacts: Article: Maria Grazia Cusi, 01139 0577 233871, cusi@unisi.it ; Pierpaolo Correale, 01139 0577 586369, correale@unisi.it Editorial: NHBLI Communications Office, 301-496-4236, nhb...Retinoblastoma researchers find success with two-drug combination
...presented in this work, there were few options for preclinical studies on retinoblastoma. A knockout model is one that lacks one or more specific genes; knockout models are developed in order to study specific human diseases caused by gene defects. The investigators made their findings during a sequence of expe...New therapeutic target identified in inherited brain tumor disorder
...ind that fumagillin inhibits brain tumor growth in preclinical studies, it will be a much smaller leap to using these compounds in patients with NF1," says senior investigator David H. Gutmann, M.D., Ph.D., the Donald O. Schnuck Family Professor of Neurology at Washington University School of Medicine in St. Lou...Compound from marine bacteria shows potential as multiple myeloma therapy
...e and be better tolerated by patients as well. In preclinical studies, NPI-0052 blocks a wider range of proteasome activities than bortezomib, say the researchers, and works at lower doses. NPI-0052 also appears to be less toxic to normal cells. Bortezomib is currently given by intravenous infusion. "NPI-005......nistration (FDA) is unforgiving of mistakes in the preclinical development stage TetraQ Business Development Manager Dr Stuart Behncken said. "Australian drug development companies targeting the US market are often unaware of the issues they can encounter with the FDA, and they find that they also need help pre...