New studies identify advances in treatment of chronic myeloid leukemia
...ed with normal BCR-ABL genes, and has demonstrated preclinical activity against 18 of 19 imatinib-resistant BCR-ABL mutants. In an update of a phase I, dose-escalating study initiated in November 2003, researchers from the University of California, Los Angeles (UCLA) School of Medicine and The University of Te...New antidepressant drug increases 'brain's own cannabis'
...condition that affects around 20% of Canadians. In preclinical laboratory tests researchers found that URB597 increased the production of endocannabinoids by blocking their degradation, resulting in measurable antidepressant effects. "This is the first time it has been shown that a drug that increases endocannab...GroPep to pursue promising asthma drug following preclinical study results
...delaide biotechnology company GroPep has completed preclinical efficacy studies of its T-cell peptide drug candid...ed testing of its T-cell peptide drug candidate in preclinical models of asthma and psoriasis. The results showed that the drug was highly effective in treating as...Sangamo BioSciences demonstrates its ZFP treatment protects cells from HIV infection
...pecifically disrupt the CCR5 gene. In its anti-HIV preclinical research program, Sangamo has designed ZFNs that can be used to disrupt the CCR5 gene, a receptor required for HIV entry into immune cells. The researchers found that ZFN-modified cells were resistant to HIV infection whereas control cells were infe...Antibody therapy promising for pediatric neuroblastoma
...hat stimulate the T lymphocytes. A report on these preclinical studies appears in the December 1 issue of Clinical Cancer Research. The St. Jude strategy represents an improvement on a similar technique that showed great promise during clinical trials in Germany and elsewhere, according to Barfield, who is a co-...NIAID researchers show how promising TB drug works
...ry, III, Ph.D., who headed the research team. In preclinical testing, PA-824 showed evidence of being effective against both actively dividing and slow-growing M. tb, giving rise to optimism that the compound may be useful in treating both active and latent TB. (For information about the first clinical trial o...Motor symptoms associated with increased risk for future Parkinson's disease
...otion that clinically manifest PD is preceded by a preclinical phase that is not entirely asymptomatic," the authors report. "Subjective complaints related to motor function might indicate a very early phase of not-yet-diagnosable PD during which dopamine loss is not sufficient to produce overt typical PD sympt...New licensing agreement to maximize AIDS drug development
... the U.S and Thailand and Cyanovirin-N which is in preclinical testing. Henry Gabelnick, Ph.D., executive director of CONRAD says, "This agreement is great news for everyone interested in developing an effective microbicide. The more partnerships we have like this one, the better our potential is for getting an ...Brain scans may predict cognitive decline in normal people
...e imaging (MRI) could eventually be used to detect preclinical signs of Alzheimer's disease. "Our paper is one of the few to show that it is possible to detect changes in the brains of normal older people who experience subsequent cognitive decline," said Dr. William Jagust, UC Berkeley professor of neuroscience...New study shows xenon gas safe in surgery and could help stop nerve damaging illnesses
...rokes, and brain and spinal cord injuries. Earlier preclinical work by the team showed that xenon was effective as a neuroprotectant, stopping processes present during strokes or brain and spinal cord injuries that would damage nerve cells. They found that xenon was capable of blocking the effects of a particula...Doernbecher researchers to study effectiveness of stem cell transplant in human brain
...enetics in the OHSU School of Medicine. "While the preclinical research in the laboratory and in animals is promising, it is important to note that this is a safety trial and, to our knowledge, purified neural stem cell transplantation has never been done before. It is our hope that stem cells will provide an im...Study indicates human susceptibility for variant Creutzfeldt-Jakob disease transmission
...nset of symptoms. The authors conclude: "A lengthy preclinical disease is predicted by these models, which may represent a risk for further disease transmission and thus a significant public-health issue." In an accompanying Reflection and Reaction article, Corinne Lasmzas comments that although a small number o...Lack of response to herceptin may be reversed with addition of a PI3K inhibitor
...s in other breast tumors that lack PTEN." Based on preclinical data from Yu's team, Francisco Esteva, M.D., Ph.D., an associate professor in the Department of Breast Medical Oncology, will be conducting the clinical trial....UQ research will move medicines to market more quickly
...s is due to a lack of innovation in the pathway of preclinical trials, which are required before drugs move into ...centre aims to develop new tools to streamline the preclinical trials process, which will be made available to biotechnology companies via TetraQ. This toolkit wil...University of Utah to help build bionic arm
... project. He also will participate particularly in preclinical and human studies of the interface device with hand-and-arm surgeon Douglas T. Hutchinson, an associate professor of orthopaedics, and Nicholas Brown, a research assistant professor in orthopaedic surgery. Other University of Utah co-investigators ...M. D. Anderson: Setting the benchmark in brain tumor treatment
...nt Therapeutics, has led to a rapid translation to preclinical and clinical development of the drug, WP744 (also known as RTA744). A phase I, 30-patient clinical trial at M. D. Anderson, which is being led by Conrad, is in progress. "This design of WP744 was based on doxorubicin, a widely used drug that is very...New study finds PET imaging value in tracking diabetes progression
...tity of insulin-producing pancreatic beta cells. A preclinical study demonstrating that beta cells can be non-invasively imaged in rats is being published online this week (5/18, 5pm EDT) in the Journal of Clinical Investigation (June print issue). Led by a Columbia University Medical Center research team, the ...Desvenlafaxine data show significant improvement in symptoms of depression in adults vs. placebo
...PA, desvenlafaxine succinate exhibited activity in preclinical models of depression and anxiety....Early results find activity in drug that turns on tumor 'death' receptors
...g conducted at five centers around the country. In preclinical studies, Apo2L selectively induced programmed cell death (also known as apoptosis, or cell suicide) in cancer cells while sparing normal cells. It showed activity in animal models of leukemia, non-small cell lung cancer, melanoma and cancers of the c...Clinical trial confirms novel EGFR antibody targets tumors but not normal tissues
..., but not to normal human tissues. These and other preclinical data suggest that 806 would not have the side-effects observed with other EGFR-targeting mAbs." The 806 antibody has been licensed exclusively to LSP, which is working closely with LICR investigators to develop its commercial potential. "We think the...