New contrast agents may be on horizon for better medical imaging
...last? All of those kinds of things are part of the preclinical work, before people can even consider using it."...Mixed results comparing use of manual vs. automated chest compression following cardiac arrest
...ign and implementation strategies may need further preclinical evaluation. The results of this study underscore the complexity of resuscitation from out-of-hospital cardiac arrest. Further work is required to understand the interaction of manual or assisted chest compressions with other aspects of resuscitation...Baxter and Jerini advance program to develop non-intravenous haemophilia therapy
...al for milestone payments for achieving discovery, preclinical and clinical goals as well as royalties in the event of marketing approval....Measuring proteins in spinal fluid may provide early clue to Alzheimer's disease
...ele. "These findings have implications for the preclinical diagnosis of Alzheimer's disease, as well as for treatment," the authors conclude. "Therapeutic strategies aimed at prevention of Alzheimer's disease may need to be applied in early midlife or even younger ages to have maximal effect on amyloid depo...Supertron raises $3.5 million in Series C Financing
... of next-generation solutions for high-performance preclinical and clinical Magnetic Resonance Imaging (MRI) coil...applicable in both high and low-field clinical and preclinical research environments imaging objects from molecules to man. Supertron is also targeting emerging ...Scripps research team reverses Friedreich's ataxia defect in cell culture
... "so as to move Dr. Gottesfeld's compounds through preclinical drug development and into clinical trials just as quickly as possible." Other Friedreich's ataxia treatments under development are largely aimed at better treating symptoms of the disease, rather than grappling with the root cause of low frataxin p...NHLBI and NIH statements on totally implanted permanent artificial heart
...s great public impact from basic research through preclinical testing and on to clinical readiness. The total artificial heart will extend and improve the quality of life for patients who have no other treatment option. This accomplishment also demonstrates the kind of long term interdisciplinary scientific ...Accelerating weight loss may signal development of Alzheimer's disease
...rger studies, they conclude, "weight loss may be a preclinical indicator of Alzheimer's disease."...Impaired gene helps non-small cell lung cancer resist drug
...t is often disabled in cancer. Ji said additional preclinical and toxicity studies in animal models have been planned to develop a treatment protocol using the NPRL2-nanoparticle plus cisplatin for future clinical trials in lung cancer patients....New mechanism underlying pain found
...he root-cause of chronic neuropathic pain, and the preclinical validation of new targets for pharmaceutical thera...e's heart rate. "What we have shown in our early preclinical research is that we can inhibit the inappropriate neuronal activity and resulting sensitivity that f...Autoimmune disease triggered if T cells miss a single protein early on
...one, PhD, director of the UCSF Diabetes Center, in preclinical studies to see if T cell autoimmune attacks on IRBP can be modulated to prevent the autoimmune eye disease....Drug combination proves effective against myeloma in Phase I trial
...issue in the bone marrow. The trial was based on preclinical work that found Revlimid increases myeloma cells' vulnerability to Velcade and dexamethasone, which suggested that patients might benefit from a combination of them. The encouraging results of the Phase I study have prompted investigators to begin Ph...MIT implant could measure tumor growth, treatment
... for the research group is to start more extensive preclinical testing. They will be looking for a hormone, human chorionic gonadotropin (HCG), that can be considered a marker for cancer because it is produced by tumors but not normally found in healthy individuals (unless they are pregnant). The researchers a...Preclinical results of Geovax's AIDS vaccines demonstrate potential to protect against disease
... company, today reported successful results from a preclinical trial using GeoVax's vaccines for the therapeutic ...DS," said Don Hildebrand, CEO of GeoVax Labs. "Our preclinical trials, coupled with encouraging data from two ongoing human trials, help validate the science behin...University of Leicester research reveals rice bran could reduce risk of intestinal cancer
... The results of a controlled laboratory study in a preclinical model of gastrointestinal adenoma demonstrated that consumption of a high daily dose of stabilized rice bran caused an average 51% reduction in the number of precancerous adenomas in the intestinal tract. Professor Andreas Gescher of the University...World-renowned chemist honored with inaugural lectureship
...unds from conception through laboratory synthesis, preclinical evaluation and into clinical trials. His modified epothilones (a new class of cytotoxic molecules) are currently in Phase I and Phase II breast cancer clinical trials. He also discovered fludelones, a remarkable class of compounds which show...PneuStep -- MRI-safe motor makes robotic biopsies possible
... prostate gland. The robot currently is undergoing preclinical testing. "Prostate cancer is tricky because it only can be seen under MRI, and in early stages it can be quite small and easy to miss," says Stoianovici. The new Johns Hopkins motor, dubbed PneuStep, consists of three pistons connected to a ser...Correlation between bile duct obstruction and ductal cancer found
...r drug therapy. Second, they establish a unique preclinical model of how bile duct cancer in liver progresses that can be used to rapidly test and evaluate novel molecular treatment strategies. Such strategies are badly needed for this understudied cancer, adds Dr. Sirica. The incidence and mortality of cho...Secondhand smoke increases risk of dementia
...carotid arterial walls, and serve as indicators of preclinical cardiovascular disease and are risk factors for stroke. People with these underlying conditions and high lifetime exposure to secondhand smoke were nearly two-and-a-half times as likely to develop dementia as those with no secondhand smoke exposure a......th of the children who succumb to it anddie." With preclinical modelling in mice having been encouraging, Professor Tindle said clinicaltrials were forthcoming, leading the way to the vaccine becoming available in the clinic.He hoped it would become one of the vaccines given to all infants in their first threemo...