BI-RADS lexicon for ultrasound useful for differentiating benign from malignant solid masses
...researchers found that the descriptors were highly predictive for both malignant and benign masses. For malignant lesions, descriptors such as "spiculated margin" were accurate in 86% of the instances, "irregular shape" in 62% and "nonparallel orientation" in 69%. For benign lesions, descriptors such as "circum...2005 Potamkin Prize goes to neurologists for research in early detection of Alzheimer's disease
... have stimulated an intensive search for sensitive predictive biomarkers of AD." Petersen's research has focused on mild cognitive impairment (MCI). "This represents the earliest clinical features of the disorder that will ultimately become Alzheimer's disease," Petersen said. "Currently, several treatment tria...Clinical diagnosis of Alzheimer's may be delayed, says major clinical trial
...a multi-site study and the finding that MCI can be predictive of AD. A condition whose characterization in the medical community is relatively new, MCI is a transitional state that occurs between the cognitive changes of normal aging and the very early stage of AD. The amnestic subtype of MCI, the focus of this...One-meter waistline predicts high risk of diabetes and heart disease
... Statistical modelling was then used to assess the predictive power of each variable Waist circumference was a very strong independent predictor of insulin sensitivity. A waist circumference of less than 100 cm excluded insulin resistance in both sexes. It replaces body mass index, waist:hip ratio, and other me...Northwestern's cancer genetics program finds gene variants that greatly increase breast cancer risk
...nsive cancer genetics program that provides cancer predictive gene testing and genetic counseling. TGFBR1*6A testing is currently only offered at Northwestern as part of a research protocol at the Cancer Genetics Program, but Dr. Pasche predicts that testing for this gene will enter the mainstream of genetic t...Measuring enzymes at end of cancer pathway predicts outcome of Tarceva, Taxol
...ve use of Tarceva," he says. The only experimental predictive test currently available is whether lung cancer cells have a mutation in their epidermal growth factor receptor (EGFR), but that does not predict response to the targeted therapy in other forms of cancer, Ueno says. "We find here that as long as CDK2...Revised Bethesda guidelines effective at identifying patients at risk of colorectal cancer
...ecificity, 98.0 percent and 98.2 percent; positive predictive value, 27.3 percent and 29.0 percent, respectively) to identify MSH2/MLH1 gene carriers. Further analysis confirmed the revised Bethesda guidelines as the most discriminating set of clinical parameters. "In conclusion, our results demonstrate that th...Specific behaviors seen in infants can predict autism, new research shows
...s called. "The predictive power of these markers is remarkable", says Dr. Zwaigenbaum. "We are finding that within this high-risk group of siblings, almost all of the children who are diagnosed with autism by age two years have seven or more of these markers by the time they...New prognostic markers help identify risk of relapse
... a low absolute neutrophil count (ANC), was highly predictive of relapse. "Many traditional predictive factors have lost their significance over time, so there is a real need to find new markers that can...Perceived discrimination linked to coronary artery calcification
...ome studies finding that arterial calcification is predictive of clinical events such as heart attack. The study included 181 African-American women, ages 45 to 58, from the Chicago, and Pittsburgh, Pa., areas. The women answered a nine-item Everyday Discrimination Questionnaire regarding their experience of ...Tools for diagnosing heart attack could be inaccurate in some populations
... Miller said. "Age and male gender also had little predictive power in evaluating whether these patients were having a heart attack." Miller said the results suggest that doctors should consciously consider the effects of racial or ethnic differences when they use the tools. In addition, they point to the impor...Autism conference reports advances in early diagnosis, role of immune system and more
...e identifiable in the first year of life, that are predictive of autism. Lonnie Zwaigenbaum at McMaster Universi... reported that vocal differences at 12 months were predictive of autism in high-risk infants (those with older siblings who have autism, and Sally Rogers of the U...Scientists report strong evidence of alterations in blood samples of children with autism
...rences we can detect in blood samples that will be predictive of the disorder, though we are still some years away from having an actual diagnostic blood test for autism. Scientists have long suspected there were distinct biological components to autism but the technology needed to reveal them has only recently...Carbonated soft drinks and sleeping pills cause heartburn during sleep
...r from excessive daytime sleepiness." To determine predictive factors of heartburn during sleep, researchers from Tucson, AZ, Boston, MA, Baltimore, MD, and Minneapolis, MN, distributed self-report sleep habit questionnaires to 15,314 people from nine centers across the United States. The questionnaires asked ...Presence of high-risk prostate cancer can be predicted without a biopsy, new study says
...t PSA density is by far the clinical variable most predictive of Gleason score," Garzotto said. Men who had a PSA density elevated to above 0.18 had a 24-fold greater chance of high-grade prostate cancer than men whose PSA density was low or normal....American Thoracic Society Journal news tips for May 2005 (second issue)
...om a prospective study directed at determining the predictive value of using noninvasive measures to monitor airway inflammation in children with asthma who have undergone inhaled corticosteroid medication reduction. British investigators showed that successful lowering of inhaled corticosteroid doses could be ...Mayo researchers seek methods to make new cancer therapies available more quickly
...t year that outcomes after three years were highly predictive of the five-year outcomes, so we went back and asked 'could we look after one year or two years,' " says Dr. Sargent. "Our new results suggest that two years is almost as good as three years, but that one year is too early." Last year, Dr. Sargent pr...Computed tomography has potential to offer accurate, safer method for detecting artery disease
...ensitivity, specificity, and positive and negative predictive values of MSCT were 95 percent, 98 percent, 87 percent, and 99 percent, respectively. Quantitative comparison of MSCT and invasive coronary angiography showed good correlation, with MSCT systematically measuring greater-percentage stenoses. Per-patie...Treating autism 'right the first time'
...logy, the study is the first to develop and test a predictive profile of children likely to respond to a particu...st exceptional responders were used to develop the predictive profile. Children expected to do well with PRT were those who showed a moderate to high interest in ...American Thoracic Society Journal news tips for June 2005 (first issue)
...er prevalence of 18 percent, positive and negative predictive values were slightly over 66 percent and approximately 92 percent, respectively. The researchers noted that their results prove the feasibility of the concept of using the "electronic nose" to detect and manage lung cancer. However, further study is...