DNA vaccine against multiple sclerosis appears safe, potentially beneficial
...lls of atorvastatin calcium, a lipid-lowering drug previously shown to be effective in autoimmune conditions. After 13 weeks, participants who initially received placebo received four injections of BHT-3009. Magnetic resonance imaging (MRI) and other safety evaluations were performed at the beginning of the s...Adverse housing conditions contribute to diabetes risk
...riety of socioeconomic backgrounds. Adjusting for previously recognized diabetes risk factors such as weight, smoking, exercise, alcohol use, marital status and education, the researchers found that housing conditions influenced the risk of developing diabetes, although there was no direct association with con...Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinson's symptoms
... loss of two types of brain cells--not just one as previously thought--may trigger the onset of symptoms associated with Parkinson's disease. The evidence, based on mouse models, shows a link between the loss of both norepinephrine and dopamine neurons and the delayed onset of symptoms associated with Parkins...New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
...n University Medical Center, indicates that a gene previously thought to be unrelated to breast cancer may be responsible for some resistance to endocrine therapy. The gene, called human X-box binding protein-1 (XBP1), is an alternatively spliced transcription factor that participates in a stress-signaling pa...Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
... pregnancy and poor academic performance have been previously documented. Meanwhile, the rate of childhood obesity has tripled in the United States during the past 25 years. The four indicators of increased absenteeism among school children have traditionally been race, socioeconomic status, age and gender. ...Pathway links inflammation, angiogenesis and breast cancer
...ecrosis Factor alpha (TNFa). "What we found is a previously unrecognized role for IKKbeta, a protein kinase ac... outside of the nucleus. Together, the two kinases previously were known to free the oncoprotein nuclear factor kappa B (NF"B) from the cytosol, allowing it to mo...Researchers suggest TB screening for all international adoptees
... American tuberculosis standards. If the child was previously in an orphanage or childrens home, the state tuberculosis program should, in consultation with the adoptive family, notify the orphanage or home, as well as the adoptive agency. As many international adoptees have no medical history documents, syst...Hormone regulates fondness for food
...ns - respond to pictures of food. These areas have previously been linked to pleasant and rewarding emotions and desires. When the patients were treated with leptin, responses to food pictures in these areas were reduced. One of the striatal regions - the nucleus accumbens - was especially responsive to pict...Researchers find vitamin B1 deficiency key to vascular problems for diabetic patients
...betic patients. This significant decrease had been previously masked as the conventional way of assessing levels of thiamine status was to measure the activity of an enzyme called transketolase in red blood cells. Past studies had seen normal activity of this enzyme and assumed normal levels of thiamine when in...Theory of facial aging gets a facelift from UT Southwestern researchers
...of Plastic and Reconstructive Surgery , challenge previously held theories regarding aging and may offer new ways to help turn back the clock, UT Southwestern plastic surgeons say. For hundreds of years, everyone has believed that the fat on the face is one confluent mass, which eventually gets weighed down ...ACC/AHA release revised UA/NSTEMI guidelines
...blockade, a new drug category that wasnt available previously for people with heart failure, said Wenger. High-dose antioxidant vitamin supplements such as beta carotene, vitamins E and C and folic acid for secondary prevention are no longer recommended because results from clinical trials have shown no benefi...Why women get more migraines than men
...eadache frequency. These were all patients who had previously tried other treatments without success. While Charles cautioned that these results need to be confirmed with a larger study, the encouraging results are an example of how new insights into the basic mechanisms of migraine are leading to novel appr...European heat waves double in length since 1880
...pe's climate has become more extreme and confirm a previously hypothesized increase in the variance of daily summer temperatures since the 19th century. The study adds evidence that heat waves, such as the devastating 2003 event in western Europe, are a likely sign of global warming; one that perhaps began as...Medical residents score poorly in diagnosing and managing tuberculosis
...y to be the first point of contact for people with previously undiagnosed TB. Karakousis says large metropolitan areas are prone to more cases of TB because of social factors, including high rates of homelessness, drug use, incarceration and immigration, as well as HIV infection. He points out that the surv...Medical residents unclear about TB guidelines
...to be the first point of contact for patients with previously undiagnosed TB, it is important that they are properly trained in spotting and treating this infectious disease. We cannot be sure that lack of tuberculosis knowledge leads to poor management of patients, says Karakousis. Although trainees may scor...Spuds that like you -- in your summer salad
...ect on irritable bowel syndrome (IBS). Ohmans team previously found that the overall lymphocyte levels do not vary for IBS patients, but that lymphocytes are transferred from the peripheral blood to the gut, which support the hypothesis of IBS being at least partially an inflammatory disorder. She says the decr...Report calls for new directions, innovative approaches in testing chemicals for toxicity to humans
...opulation studies may also reveal health risks not previously identified through toxicity testing. In addition, human exposure data can be used to select doses for toxicity testing, so that the tests generate information on biological effects at environmentally relevant exposures. By comparing human exposure ...Study outlines how stroke, head injury can increase risk of Alzheimer's disease
...ernative, non-toxic protein. The MGH-MIND team previously reported that cellular BACE levels are normally controlled by the enzymes breakdown in compartments called lysosomes, a process that is disrupted if a molecular signal on the enzyme is altered. That signal binds to GGA proteins, which are required f...High-Need Physician Workforce Incentives Act endorsed by American College of Physicians
...llars bill will create targeted incentives, as ACP previously has proposed, to encourage students to pursue careers as primary care physicians, Dr. Dale noted. The legislation also will provide grants to states to provide physicians with care coordination fees for managing and coordinating care, in partnership...