Two central mysteries in genome inheritance solved at UCSD
...n that breakdown of this connection could stop the proliferation of cancerous cells, they didn't know how the connection itself was established. Using a biochemical approach, Desai and postdoctoral fellow Iain Cheeseman, Ph.D., have solved this mystery. In the December 1 paper, they identified a protein group t...Researchers make progress against lung disease attacking women in childbearing years
...d the first step, finding out what caused the cell proliferation and identifying the mutating gene that was responsible. Next, Krymskayas lab at the University of Pennsylvania was responsible for the breakthrough step of discovering the function of the gene that caused the cell malfunction, paving the way for a po...Smoking worsens knee osteoarthritis
... Smoking may disorder the cells and inhibit cell proliferation in the knee cartilage Smoking may increase oxidant stress, which contributes to cartilage loss Smoking may raise carbon monoxide levels in arterial blood, contributing to tissue hypoxia (insufficient blood oxygenation), which could impair cartilage...Blood pressure drugs could help halt pancreatic cancer spread, Jefferson researchers find
...am is looking at the effect of angiotensin on cell proliferation and programmed cell death, and would like to develop an animal model. "Patients have chemotherapy and radiation sometimes before surgery," she says. "I would imagine this would be useful either for unresectable tumors or after surgical removal of th...5-year study shows Gleevec's potency against chronic myeloid leukemia
...rearrangement of a chromosome, drives uncontrolled proliferation of white blood cells. CML is a relatively rare disorder that affects about 5,000 people a year in the United States. Gleevec, marketed by Novartis, is the trade name under which the drug imatinib is sold. The five-year study followed 553 patients, ...Regulatory pathway in brain development possible basis for malformations
... light on how immature neural cells choose between proliferation and differentiation. Defects in regulating this c...ind of malformation, which appears both to promote proliferation and to help coordinate differentiation of immature precursor cells." The work in Hamilton's lab, l...Nicotine receptors on kidneys may speed kidney damage
...). Exposure to nicotine increased mesangial cell proliferation by 50 percent to 80 percent. Researchers measured mesangial cell proliferation by the ability to incorporate 3H-thymidine -- a radioactive marker commonly used to assess mesangial...Scientists stop colon cancer growth in mice by blocking just one enzyme
... encourage colon cancer cells to proliferate; this proliferation process then itself produces even more inflammation and cancer cell growth. (Chronic inflammation is strongly linked to the development of colon and other cancers.) The researchers then blocked aldose reductase activity and checked the responses of...Impaired gene helps non-small cell lung cancer resist drug
...ion with cisplatin drastically limited cancer cell proliferation and increased programmed cell death (apoptosis) of cancer cells by 2 to 3 fold. "We also demonstrated in a mouse model of human cisplatin-resistant non-small-cell lung cancer that gene therapy to restore NPRL2's function makes the tumors once again ...New drug target might sidestep gleevec resistance, Jefferson scientists show
... overactive BCR-ABL, in turn, drives the excessive proliferation of white blood cells. In one study, reactivating C/EBP-alpha in Gleevec-resistant mice cured leukemia in six out of seven animals. This isn't surprising, Dr. Calabretta says, because C/EBP-alpha isn't involved in the mechanism of action of Gleeve...Molecule helps cells plug leaks following lung injury
...group was similar, there was less endothelial cell proliferation in the gene-deficient mice after the injury, suggesting that inability to fill the gaps in the barrier with new cell growth impaired the ability to recover. Asrar Malik, professor and head of pharmacology at UIC, says the results suggest that lung ...Mutation plays key role in hypertension
...of the smooth muscle cells. They do not affect the proliferation of the cells, and the thickening of the walls of b...in the cell, and, ultimately, more contraction and proliferation of smooth muscle cells," she said. The transcription factor that binds the mutated gene more easily...Pall system to detect blood bacteria given CE mark
...gen is consumed through the metabolic activity and proliferation of the bacteria during incubation, resulting in a measurable decrease in oxygen content. The study presented to the ISBT tested the Pall eBDS on 662 red blood cell samples that had been inoculated separately with twelve different bacteria strains. Ea...Estrens might not be the answer for osteoporosis
...ncreased in size. Furthermore, estrens induced the proliferation of human breast cancer cells. This study indicates that estrens might not be the sought after estrogen-like molecules that improve bone strength but do not cause cancer, and has important implications for their clinical development. In an accompany...Molecular switch may turn off immune cells that target HIV
...ion. Blocking the PD-1 pathway also increased the proliferation of HIV-specific CD4 cells, and even cells from ind...t previously had no detectable response had robust proliferation after pathway blockade, indicated that cells that had been turned off could be turned back on. "I...Researchers discover how acid reflux leads to esophageal cancer
...id exposure to increased ROS production, increased proliferation and decreased apoptosis may provide a number of potentially useful therapeutic targets," the authors write....Jefferson scientists show 'miracle' cancer drug Gleevec can be toxic to the heart
... overactive BCR-ABL, in turn, drives the excessive proliferation of white blood cells that is the hallmark of CML. According to Dr. Force, 10 patients taking Gleevec at the University of Texas' M.D. Anderson Cancer Center in Houston developed fairly severe heart failure, with no prior symptoms. Because physicia...Mass. General study finds potential ovarian cancer stem cells
...s potential to maintain the ability to inhibit the proliferation of these cells, MIS may play a role in these new therapeutic approaches," Donahoe says. "We intend to keep searching for stem-like cells in patient tumor samples and to study their responsiveness to both chemotherapeutic agents and to novel agents s...Cycles of cell death, proliferation key to liver cancer
...to cell death; if activated briefly, it stimulates proliferation of pre-malignant and cancerous tumor cells," said ...se to liver injury, as well as what stimulates the proliferation of surviving hepatocytes," said Karin. "Since we previously knew that JNK activity is required for n...Summer update: Melanoma research progress suggests optimism for future cures
...ges, or signaling pathways, keep cell division and proliferation orderly. But disruptions in these signals can lead to the kind of uncontrolled cell divisions seen in melanoma. In experiments, Herlyn has found that he can re-establish broken communication between cells, thus restoring control over this wayward cel...