Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection
...t blockade of CTLA4 lifts the inhibition of T cell proliferation and allows both Tregs and Teff cells to proliferate in response to exposure to self-antigen. Interestingly, combination of CLTA4 blockade with Gvax selectively primes the anti-tumor Teff cells for action. This led to greater infiltration of Teff cell...Study uncovers 'significant' functional differences of novel estrogen receptor
...trogens and anti-estrogens can both stimulate cell proliferation through membrane-associated hER-?36. "By identifying and cloning a novel form of the human estrogen receptor, our studies suggest that hER-?36 may have a greater potential to signal estrogen stimulated membrane responses than hER-a66," Deuel said. "...OHSU researchers discover possible HIV therapy in an animal study
...to HIV-positive patients and are shown to slow the proliferation of the HIV virus, allowing patients to live longer. This research clearly demonstrated the importance of retroviral drugs in allowing for restoration of T cell population. This was done by observing SIV-positive animals that received IL-15 without an...Green tea and the 'Asian Paradox'
...atelet aggregation, regulates lipids, and promotes proliferation and migration of smooth muscle cells, which are all factors in reducing cardiovascular disease, he said. Sumpio said other reports show that EGCG prevents growth of certain tumors. Tea, according to studies, also can improve gastrointestinal functio...New protein target may advance design of HIV and cancer drugs
...paper, the HIV NCp7 protein is responsible for the proliferation of the HIV virus. If researchers can inhibit the action of this zinc finger protein, they can stop the spread of the virus. "When we target specific viruses with drugs, over time patients can become resistant to treatment and the drug becomes ineffe...No link between short-term testosterone use and prostate cancer, study says
...Furthermore, gene expression was not altered, cell proliferation was not accelerated, and histologic cancers were not increased. The study also showed testosterone therapy created positive effects in bones and muscles. "The prostate appears to be buffered against rather wide fluctuations in serum testosterone lev...New compound unusually potent at blocking brain cancer growth
...s PI-103, shows unique potency against cancer cell proliferation in studies of mice with grafts of human glioma cel...o be a safe and effective inhibitor of cancer cell proliferation in mice with the human tumors, the scientists found. The glioma research is being published online M...M. D. Anderson: Setting the benchmark in brain tumor treatment
...ts topoisomerase II, a key protein involved in the proliferation of malignant gliomas. A multidisciplinary collaboration between Priebe, Conrad, and Timothy Madden, M.D., associate professor in the Department of Experiment Therapeutics, has led to a rapid translation to preclinical and clinical development of the...St. Jude unlocks mystery of very aggressive leukemia
...e is unknown. The Arf gene normally suppresses the proliferation of cells carrying cancer-causing mutations such as...uced in the bone marrow, IL-7 further enhanced the proliferation of cultured leukemic cells removed from the mice and made the cells resistant to imatinib's growth i...JCI table of contents, April 6, 2006
... This work suggests that vGPCR directly stimulates proliferation of endothelial cells and that it is centrally invo...rus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells AUTHOR CONTACT: Sergio A. Lira Mount Sinai School of Medicine, New York, New ...Lack of response to herceptin may be reversed with addition of a PI3K inhibitor
...ntrols an oncogenic pathway that includes the cell proliferation kinases Akt and mTOR. Yu decided to test what would happen if she administered an experimental drug that blocks PI3K, and thus mimics PTEN's tumor suppressor activity. In this study, the research group tested seven different PI3K inhibitors that are...Fat cells around coronary arteries may play a role in heart disease
...werful stimulator of angiogenesis and resulting in proliferation of the vasa vasorum, which has been suggested to contribute to coronary artery disease by causing intraplaque hemorrhage and accumulation of cholesterol from red blood cell membranes. The fat cells surrounding coronary arteries may ultimately prove t...Jefferson scientists reveal new mechanism that causes spread of colorectal cancer
...astasized, and is fundamental to permit tumor cell proliferation to distant sites," Dr. Pitari says. "In addition to stromal cells, the tumor cell itself is a good source of MMP-9 and in fact, is doing the seeding of the colon cancer, promoting metastasis. No one has ever shown this particular mechanism. The curre...International award honors M. D. Anderson President for pioneering research
...ed out research on how growth factors regulate the proliferation of cancer cells. Working with Dr. Gordon Sato and collaborators in the early 1980's, he created a monoclonal antibody that blocked the capacity of the epidermal growth factor to activate a specific receptor on cancer cells, resulting in inhibition of...Comparison of drug-releasing coronary stents show similar effectiveness
...ntimal [a new layer of cells on the inner surface] proliferation suppression to translate into significantly different rates of binary restenosis or adverse clinical events," the authors conclude....First disease-specific (breast cancer) protein library opens new drug paths
... to examine their relationships to cell migration, proliferation and morphogenesis. From this screen, the research...ns that had not previously been implicated in cell proliferation were identified. The morphogenesis and migration screens produced the greatest number of hits from t...Using statins to potentially treat rheumatoid arthritis
... and tumor cells. Rheumatoid arthritis (RA) causes proliferation of synovial tissue, which lines the joints, but li...el way of treating the disease. The activation and proliferation of synovial cells, which is thought to play a key role in RA, may be exacerbated when apoptosis of s...Low cholesterol cues cataract development
...ng that the defect in cholesterol synthesis alters proliferation of these cells and contributes to the lens becoming opaque. The results could have clinical impact in patients taking cholesterollowering medications or in individuals with inborn defects in cholesterol synthesis....JCI table of contents, January 26, 2006
...ng that the defect in cholesterol synthesis alters proliferation of these cells and contributes to the lens becoming opaque. The results could have clinical impact in patients taking cholesterollowering medications or in individuals with inborn defects in cholesterol synthesis. TITLE: Lanosterol synthase mutatio......e fight to destroy invading bacteria or fungi. The proliferation and activity of T cells is carefully controlled by a subset of cells known as regulatory T cells (Tregs). Treg depletion may allow an overzealous immune response to turn against the body's own tissues, resulting in autoimmune disorders such as arthri...